Browsing Human- und Zahnmedizin by Advisor "Müller, Michael Prof. Dr."
Now showing items 1-20 of 25
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Fluorespirometrische Charakterisierung mitochondrialer Dysfunktion der Hirnregionen Cortex und Hippocampus eines Mausmodells für das Rett-Syndrom
(2025-06-24)Rett syndrome, typically caused by mutations in Methyl-CpG-binding protein 2 (Mecp2), is a severe neurodevelopmental disorder. Mitochondrial dysfunction is implicated as a significant factor in its pathogenesis. This study ... -
Modulation der zytosolischen Redox-Balance durch aktivitätsinduzierte Ca2+-Signale in hippokampalen Neuronen der Maus
(2025-06-24)Intracellular Ca2+ signals are essential for the modulation of cellular activity and excitability but also represent critical components of cellular dysfunction and damage in various neurological disorders. The aim of this ... -
Zerebrale Kartierung der neuronalen Redox-Veränderung in einem Maus-Modell für das Rett-Syndrom
(2025-06-24)As part of this study, changes in the neuronal redox balance in the brains of Rett mice are mapped and correlated with the progression of Rett syndrome. Fluorescence microscopy techniques (primarily ratiometric CCD camera ... -
Redoxmodulation epileptischer Anfälle in einem Mausmodell für das Rett-Syndrom.
(2024-10-16)The aim of the present dissertation was to investigate and evaluate the therapeutic benefit of an oral antioxidant therapy on the epilepsy symptoms associated with Rett syndrome. A shift in the cellular redox balance towards ... -
Bestimmung der mitochondrialen Atmungskettenfunktion im Rett-Syndrom mittels hochauflösender Respirometrie
(2023-06-05)Rett syndrome is a disorder frequently caused by pathological changes in the MECP2 gene, an essential transcription factor. It results in various morphological and biochemical alterations in mitochondria, which affect a ... -
Spreading Depression induzierte Redoxveränderungen in hippokampalen Neuronen der Maus
(2022-08-03)Spreading depression (SD) is a neurological phenomenon characterized by massive neuronal and glial depolarization that slowly spreads in brain tissue at rates of several millimeters per minute. Due to the almost complete ... -
Therapeutischer Nutzen einer stabilisierten systemischen Redoxbalance im Rett-Syndrom: Bewertung plethysmographischer und elektrophysiologischer Parameter
(2022-03-08)Rett syndrome is a neurodevelopmental disorder caused by mutations in the X-linked MECP2 gene. The MECP2 gene encodes MeCP2 (methyl-CpG-binding protein 2), which acts as a transcriptional regulator and can stimulate and ... -
Einfluss der Rett-Syndrom-assoziierten MeCP2-Defizienz auf die DNA-Oxidation, strukturelle und inflammatorische Marker in zerebralem Gewebe
(2021-11-26)Rett-Syndrome is a disorder with impaired neuronal development, in which mutations in the MECP2 gene lead to severe motor and cognitive impairment. Part of a complex clinical appearance are a disturbed cardiorespiratory ... -
Modulation der synaptischen Plastizität im Rett-Syndrom durch Antioxidantien-Fütterung
(2021-10-05)Rett syndrome is a severe neurodevelopmental disorder that almost exclusively affects females. Upon an apparently normal development during the first 6 – 18 months of life, developmental stagnation and especially neurological ... -
Therapeutischer Nutzen einer mitochondrialen Katalase-Expression in einem Mausmodell des Rett-Syndroms
(2021-10-05)Rett syndrome is a severe neurodevelopmental disorder that mainly affects girls with a prevalence of 1: 10,000 to 1: 15,000. The clinical symptoms are complex and are characterized by cognitive impairment, irregular ... -
Evaluierung einer oralen Antioxidantien-Therapie in einem Mausmodell für das Rett-Syndrom
(2021-09-06)Rett syndrome (RTT) is a severe neurodevelopmental disorder caused by spontaneous mutations in the X-chromosomal gene MECP2 encoding methyl-CpG binding protein 2 (MeCP2). Affecting almost exclusively females, it causes ... -
Evaluation des Antwortverhaltens des genetisch kodierten optischen Redox-Indikators HyPer
(2020-07-07)Oxygen radicals, also known as reactive oxygen species (ROS), play a significant role in neurological diseases and in cell communication. Therefore, there is a tremendous interest in monitoring (sub)cellular redox conditions. ... -
Mitochondriale Redoxhomöostase in hippocampalen Neuronen MeCP2-defizienter Mäuse
(2019-09-11)This work should address the question of whether mitochondrially-generated ROS are the possible cause of neuronal dysfunction in RTT. Data collected in previous studies suggest that oxidative stress is important for the ... -
Funktionelles ROS/Redox Imaging, basierend auf genetisch-kodierten optischen Sensoren, exzitationsratiometrischer Zwei-Photonen-Mikroskopie und Fluoreszenzlebenszeiten
(2019-06-20)Reactive oxygen species (ROS) contribute to cellular signaling and neuropathology. There is tremendous interest in quantitative recordings of their celluar dynamics. Previously, organic dyes served to rate ROS formation ... -
Transgene Redoxindikator-Mäuse mit mitochondrialer roGFP1-Expression: Phänotypisierung, neuronales Verteilungsmuster und Sensorfunktionalität
(2017-12-05)Reactive oxygen spezies (ROS) and redox alterations determine not only physiological signaling but also lead to oxidative stress, cellular dysfunction and a wide range of pathologies. A major source of ROS-generation is ... -
Therapeutischer Einfluss des Radikalfängers Trolox in einem Mausmodell für das Rett-Syndrom: Bewertung oxidativer Stressmarker in zerebralem Gewebe
(2017-05-10)The aim of this work was to assess a variety of phenotypic and biochemical features in a mouse model of Rett-syndrome, which was treated in vivo with the free radical scavenger Trolox. Rett-syndrome is a postnatal progressive ... -
Analyse funktioneller und struktureller Mitochondrienveränderungen in einem Maus-Modell für das Rett-Syndrom mittels 2-Photonen-Mikroskopie
(2017-01-09)Rett syndrome is a neurodevelopmental disorder that is caused by de novo mutations in the X-chromosomal MECP2 gene which encodes for the transcriptional modulator methyl CpG binding protein 2 (MeCP2). Almost girls are being ... -
Oxidativer Stress und mitochondriale Dysfunktion in einem Mausmodell des Rett-Syndroms.
(2016-07-14)Rett syndrome is a postnatal neurodevelopmental disorder whose major cause are mutations in the methyl-CpG-binding protein 2 (MECP2) gene. It primarily affects girls and it is associated with cognitive impairment, motor ... -
Charakterisierung eines transgenen Mausmodells mit spezifischer zytosolischer Expression des optischen Redox-Indikators roGFP1 in Neuronen
(2015-09-04)Cellular redox alterations and reactive oxygen species (ROS) contribute to biochemical pathways and cellular signaling, but do also play a critical role in the development of neurodegenerative as well as neuropathological ... -
Extramitochondriale und mitochondriale Produktion reaktiver Sauerstoffspezies im Hippokampus MeCP2-defizienter Mäuse
(2014-05-20)Rett syndrome is a neurodevelopmental disorder caused by mutations in the X-chromosomal MECP2 gene encoding for the transcriptional regulator methyl CpG binding protein 2 (MeCP2). Rett syndrome is associated with cognitive ...