Blättern Human- und Zahnmedizin nach "Müller, Michael Prof. Dr." Betreuer
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Bestimmung der mitochondrialen Atmungskettenfunktion im Rett-Syndrom mittels hochauflösender Respirometrie
(2023-06-05)Rett syndrome is a disorder frequently caused by pathological changes in the MECP2 gene, an essential transcription factor. It results in various morphological and biochemical alterations in mitochondria, which affect a ... -
Spreading Depression induzierte Redoxveränderungen in hippokampalen Neuronen der Maus
(2022-08-03)Spreading depression (SD) is a neurological phenomenon characterized by massive neuronal and glial depolarization that slowly spreads in brain tissue at rates of several millimeters per minute. Due to the almost complete ... -
Therapeutischer Nutzen einer stabilisierten systemischen Redoxbalance im Rett-Syndrom: Bewertung plethysmographischer und elektrophysiologischer Parameter
(2022-03-08)Rett syndrome is a neurodevelopmental disorder caused by mutations in the X-linked MECP2 gene. The MECP2 gene encodes MeCP2 (methyl-CpG-binding protein 2), which acts as a transcriptional regulator and can stimulate and ... -
Einfluss der Rett-Syndrom-assoziierten MeCP2-Defizienz auf die DNA-Oxidation, strukturelle und inflammatorische Marker in zerebralem Gewebe
(2021-11-26)Rett-Syndrome is a disorder with impaired neuronal development, in which mutations in the MECP2 gene lead to severe motor and cognitive impairment. Part of a complex clinical appearance are a disturbed cardiorespiratory ... -
Therapeutischer Nutzen einer mitochondrialen Katalase-Expression in einem Mausmodell des Rett-Syndroms
(2021-10-05)Rett syndrome is a severe neurodevelopmental disorder that mainly affects girls with a prevalence of 1: 10,000 to 1: 15,000. The clinical symptoms are complex and are characterized by cognitive impairment, irregular ... -
Modulation der synaptischen Plastizität im Rett-Syndrom durch Antioxidantien-Fütterung
(2021-10-05)Rett syndrome is a severe neurodevelopmental disorder that almost exclusively affects females. Upon an apparently normal development during the first 6 – 18 months of life, developmental stagnation and especially neurological ... -
Evaluierung einer oralen Antioxidantien-Therapie in einem Mausmodell für das Rett-Syndrom
(2021-09-06)Rett syndrome (RTT) is a severe neurodevelopmental disorder caused by spontaneous mutations in the X-chromosomal gene MECP2 encoding methyl-CpG binding protein 2 (MeCP2). Affecting almost exclusively females, it causes ... -
Evaluation des Antwortverhaltens des genetisch kodierten optischen Redox-Indikators HyPer
(2020-07-07)Oxygen radicals, also known as reactive oxygen species (ROS), play a significant role in neurological diseases and in cell communication. Therefore, there is a tremendous interest in monitoring (sub)cellular redox conditions. ... -
Mitochondriale Redoxhomöostase in hippocampalen Neuronen MeCP2-defizienter Mäuse
(2019-09-11)This work should address the question of whether mitochondrially-generated ROS are the possible cause of neuronal dysfunction in RTT. Data collected in previous studies suggest that oxidative stress is important for the ... -
Funktionelles ROS/Redox Imaging, basierend auf genetisch-kodierten optischen Sensoren, exzitationsratiometrischer Zwei-Photonen-Mikroskopie und Fluoreszenzlebenszeiten
(2019-06-20)Reactive oxygen species (ROS) contribute to cellular signaling and neuropathology. There is tremendous interest in quantitative recordings of their celluar dynamics. Previously, organic dyes served to rate ROS formation ... -
Transgene Redoxindikator-Mäuse mit mitochondrialer roGFP1-Expression: Phänotypisierung, neuronales Verteilungsmuster und Sensorfunktionalität
(2017-12-05)Reactive oxygen spezies (ROS) and redox alterations determine not only physiological signaling but also lead to oxidative stress, cellular dysfunction and a wide range of pathologies. A major source of ROS-generation is ... -
Therapeutischer Einfluss des Radikalfängers Trolox in einem Mausmodell für das Rett-Syndrom: Bewertung oxidativer Stressmarker in zerebralem Gewebe
(2017-05-10)The aim of this work was to assess a variety of phenotypic and biochemical features in a mouse model of Rett-syndrome, which was treated in vivo with the free radical scavenger Trolox. Rett-syndrome is a postnatal progressive ... -
Analyse funktioneller und struktureller Mitochondrienveränderungen in einem Maus-Modell für das Rett-Syndrom mittels 2-Photonen-Mikroskopie
(2017-01-09)Rett syndrome is a neurodevelopmental disorder that is caused by de novo mutations in the X-chromosomal MECP2 gene which encodes for the transcriptional modulator methyl CpG binding protein 2 (MeCP2). Almost girls are being ... -
Oxidativer Stress und mitochondriale Dysfunktion in einem Mausmodell des Rett-Syndroms.
(2016-07-14)Rett syndrome is a postnatal neurodevelopmental disorder whose major cause are mutations in the methyl-CpG-binding protein 2 (MECP2) gene. It primarily affects girls and it is associated with cognitive impairment, motor ... -
Charakterisierung eines transgenen Mausmodells mit spezifischer zytosolischer Expression des optischen Redox-Indikators roGFP1 in Neuronen
(2015-09-04)Cellular redox alterations and reactive oxygen species (ROS) contribute to biochemical pathways and cellular signaling, but do also play a critical role in the development of neurodegenerative as well as neuropathological ... -
Extramitochondriale und mitochondriale Produktion reaktiver Sauerstoffspezies im Hippokampus MeCP2-defizienter Mäuse
(2014-05-20)Rett syndrome is a neurodevelopmental disorder caused by mutations in the X-chromosomal MECP2 gene encoding for the transcriptional regulator methyl CpG binding protein 2 (MeCP2). Rett syndrome is associated with cognitive ... -
Modulation der Hypoxie-Empfindlichkeit medullärer Netzwerke in einem Maus-Modell des Rett-Syndroms
(2012-09-14)For this thesis I investigated if elicitation of hypoxia-induced spreading depression-like depolarizations (HSDs) in the brain stem of mice is possible. Furthermore I screened for differences in hypoxia susceptibility between ... -
Erhöhte Hypoxieempfindlichkeit in Hippokampusschnitten bei einem Mausmodell des RETT-Syndroms
(2012-07-26)Rett syndrome is a neurodevelopmental disorder caused by mutations in the X-chromosomal MECP2 gene encoding for the transcriptional regulator methyl CpG binding protein 2 (MeCP2). Rett patients suffer from episodic ... -
Spektrale Eigenschaften des intrinsischen optischen Signals während hypoxieinduzierter Spreading Depression im Hippokampus der Ratte
(2011-06-29)Intinsic optical signals (IOS) regularly occur together with hypoxia induced spreading depression (HSD). IOS show a characteristic developement. First tissue reflectance becomes a little ... -
Hypoxie-induzierte Spreading-Depression-Episoden in akuten medullären Hirnstammschnitten der Ratte
(2011-04-05)This dissertation deals with the topic, if a spreading depression can be induced into the brainstem of rats. For the experiments rats were used of different age. This was important to get ...