Browsing Human- und Zahnmedizin by Advisor "Meyer, Thomas Prof. Dr."
Now showing items 1-15 of 15
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Assoziation psychometrisch erfasster depressiver Symptomatik mit dem Expressionsgrad von NF-kB bei inflammatorischen Erkrankungen des Gastrointestinaltraktes
(2020-05-29)The transcription factor NF-kB (nuclear factor-kappa B) plays an important role in the regulation of the immune responses, cell proliferation and apoptosis. The present clinical trial tested the hypothesis that there is ... -
Assoziationen psychometrisch erfasster Parameter mit Markern der Immunaktivierung bei Patientinnen und Patienten mit depressiven Syndromen
(2022-10-17)Depressive syndromes and their comorbidities are associated with a substantial psychological and somatic suffering, which significantly affect the general health, quality of life, as well as social and occupational activities ... -
Assoziationen zwischen der Einnahme oraler Kontrazeptiva und hämatologischen Parametern bei weiblichen Jugendlichen
(2020-09-08)In this post-hoc analysis, the influence of oral contraceptives on haematological parameters in n = 2775 female German adolescents aged between 13 and 17 years was examined. Data from the nationwide representative Child ... -
Auswirkungen psychologischer und multimodaler Interventionen auf psychisches Befinden und Serumkonzentrationen von Zytokinen bei Patientinnen und Patienten mit operativer Myokardrevaskularisation: Ergebnisse der I-COPE-Studie
(2022-10-17)The prevalence of anxiety and depression in context of coronary artery bypass graft are high and persist long time after the procedure. This association has been used as a target for psychological intervention in previous ... -
Die Bedeutung der Coiled-coil-Domäne für die Inaktivierung des Transkriptionsfaktors STAT1
(2020-05-07)Heterozygous gain-of-function (GOF) mutations in the transcription factor STAT1 (signal transductor and activator of transcription 1) result in increased expression of cytokine-regulated target genes. The abnormally high ... -
Der Beitrag der SH2-Domäne von STAT1 zur Regulation transkriptioneller Antworten im IFN-Gamma-abhängigen Signalweg
(2014-11-10)The interferon-inducible transcription factor STAT1 (signal transducer and activator of transcription 1) plays an important role in the defense against viral, bacterial and par-asitic infections. Well studied is the ... -
Beziehungen zwischen 25-Hydroxy-Vitamin D und Lebensqualität sowie psychischen Auffälligkeiten bei deutschen Jugendlichen
(2020-01-13)Numerous studies in adults and especially the elderly examined the association between vitamin D and quality of life. However, this relationship is less well described in children and adolescents. The aim of this study ... -
Beziehungen zwischen Lebensqualität, Verhaltensproblemen und Lipidstoffwechsel bei Jugendlichen
(2018-11-22)Earlier studies in adults have found associations between psychological distress and quality of life as well as serum lipid concentrations. However, no data are available in children and adolescents. In a post-hoc-analysis ... -
Charakterisierung der Punktmutante E449A in der DNA-Bindedomäne des humanen Transkriptionsfaktors STAT1
(2020-06-09)Signal transducers and activators of transcription (STAT) proteins play a key role in the Janus Kinase(JAK)/STAT signaling pathway. Since their discovery over twenty years ago, new evidence about the complex interaction ... -
Charakterisierung von Punktmutanten in der Linker-Domäne des humanen STAT1-Proteins
(2016-07-14)Signal transducers and activators of transcription (STATs) are components of an old phylogenetic and highly conserved signal transduction pathway in metazoans. As key elements of the JAK-STAT signal pathway, members of ... -
Charakterisierung von Punktmutationen in der DNA-Bindedomäne des humanen Transkriptionsfaktors STAT1
(2015-02-23)Signal transducer and activator of transcription 1 (STAT1) is a member of the conserved protein family of cytokine-regulated transcription factors and plays a decisive role in many biological processes such as the control ... -
Molekulare Determinanten zur sequenzspezifischen DNA-Bindung des Transkriptionsfaktors STAT1
(2018-01-09)STAT proteins (signal transducers and activators of transcription) play an essential part in one of the oldest and highly conserved signal transduction pathways. The JAK-STAT pathway transmits signals from many cytokines ... -
Reevaluation der potenziell onkogenen, Lymphom-assoziierten Missense-Mutation D427H im STAT3-Molekül
(2023-01-06)The transcription factor STAT3 (signal transducer and activator of transcription 3) promotes cell proliferation, immunomodulation, and maintenance of a stem cell state, such that its constitutive activation in cells carries ... -
Die Rolle der Linker-Domäne von STAT1 bei der Regulation transkriptioneller Antworten im Interferon-Signalweg
(2013-10-30)Signal transducers and activators of transcription (STATs) constitute an evolutionary highly conserved protein family, which play distinct roles in cytokine signaling. The family member STAT1, probably one of the best-studied ... -
The association between stress and blood pressure in a sample from the German Health Interview and Examination Survey for Adults (DEGS1)
(2015-07-14)Objective: Psychosocial stressors have long been studied for their contribution to the development of hypertension, but their role remains controversial. In this post-hoc analysis of the nationwide German Health Interview ...