Browsing Human- und Zahnmedizin by Advisor "Meyer, Thomas Prof. Dr."
Now showing items 1-19 of 19
-
Assoziationen von psychometrischen Parametern mit den Altersabständen zwischen Patientinnen mit Essstörungen und deren Eltern
(2024-07-18)Epidemiological studies identified maternal and paternal age at childbirth as significant predictors for a wide range of mental disorders in their offspring, some with positive and others with negative connotations. However, ... -
Beziehungen zwischen Geschwisterstatus und selbsteingeschätzter Familienfunktionalität bei Patientinnen mit Anorexia und Bulimia nervosa
(2024-06-20)The impact of family factors, particularly the sibling status, on the development and course of eating disorders has been rarely investigated.Therefore, the aimof the present study was to assess a putative association ... -
Axonal transport of autophagosomes in models of neurodegeneration in vitro and in vivo
(2023-12-14)Axonal degeneration is a prevalent hallmark of normal aging, trauma, and neurodegenerative CNS diseases. As an early event, it usually occurs prior to neuronal cell death, which has potential therapeutic implications. ... -
Funktionelle Charakterisierung von Substitutionsmutationen in Position 566 der Linker-Domäne des onkogenen Transkriptionsfaktors STAT3
(2023-06-08)In this work, the role of two missense mutations in position 566 of the human transcription factor STAT3 (signal transducer and activator of transcription) in relation to the activation of the JAK/STAT signalling pathway ... -
Reevaluation der potenziell onkogenen, Lymphom-assoziierten Missense-Mutation D427H im STAT3-Molekül
(2023-01-06)The transcription factor STAT3 (signal transducer and activator of transcription 3) promotes cell proliferation, immunomodulation, and maintenance of a stem cell state, such that its constitutive activation in cells carries ... -
Assoziationen psychometrisch erfasster Parameter mit Markern der Immunaktivierung bei Patientinnen und Patienten mit depressiven Syndromen
(2022-10-17)Depressive syndromes and their comorbidities are associated with a substantial psychological and somatic suffering, which significantly affect the general health, quality of life, as well as social and occupational activities ... -
Auswirkungen psychologischer und multimodaler Interventionen auf psychisches Befinden und Serumkonzentrationen von Zytokinen bei Patientinnen und Patienten mit operativer Myokardrevaskularisation: Ergebnisse der I-COPE-Studie
(2022-10-17)The prevalence of anxiety and depression in context of coronary artery bypass graft are high and persist long time after the procedure. This association has been used as a target for psychological intervention in previous ... -
Assoziationen zwischen der Einnahme oraler Kontrazeptiva und hämatologischen Parametern bei weiblichen Jugendlichen
(2020-09-08)In this post-hoc analysis, the influence of oral contraceptives on haematological parameters in n = 2775 female German adolescents aged between 13 and 17 years was examined. Data from the nationwide representative Child ... -
Charakterisierung der Punktmutante E449A in der DNA-Bindedomäne des humanen Transkriptionsfaktors STAT1
(2020-06-09)Signal transducers and activators of transcription (STAT) proteins play a key role in the Janus Kinase(JAK)/STAT signaling pathway. Since their discovery over twenty years ago, new evidence about the complex interaction ... -
Assoziation psychometrisch erfasster depressiver Symptomatik mit dem Expressionsgrad von NF-kB bei inflammatorischen Erkrankungen des Gastrointestinaltraktes
(2020-05-29)The transcription factor NF-kB (nuclear factor-kappa B) plays an important role in the regulation of the immune responses, cell proliferation and apoptosis. The present clinical trial tested the hypothesis that there is ... -
Die Bedeutung der Coiled-coil-Domäne für die Inaktivierung des Transkriptionsfaktors STAT1
(2020-05-07)Heterozygous gain-of-function (GOF) mutations in the transcription factor STAT1 (signal transductor and activator of transcription 1) result in increased expression of cytokine-regulated target genes. The abnormally high ... -
Beziehungen zwischen 25-Hydroxy-Vitamin D und Lebensqualität sowie psychischen Auffälligkeiten bei deutschen Jugendlichen
(2020-01-13)Numerous studies in adults and especially the elderly examined the association between vitamin D and quality of life. However, this relationship is less well described in children and adolescents. The aim of this study ... -
Beziehungen zwischen Lebensqualität, Verhaltensproblemen und Lipidstoffwechsel bei Jugendlichen
(2018-11-22)Earlier studies in adults have found associations between psychological distress and quality of life as well as serum lipid concentrations. However, no data are available in children and adolescents. In a post-hoc-analysis ... -
Molekulare Determinanten zur sequenzspezifischen DNA-Bindung des Transkriptionsfaktors STAT1
(2018-01-09)STAT proteins (signal transducers and activators of transcription) play an essential part in one of the oldest and highly conserved signal transduction pathways. The JAK-STAT pathway transmits signals from many cytokines ... -
Charakterisierung von Punktmutanten in der Linker-Domäne des humanen STAT1-Proteins
(2016-07-14)Signal transducers and activators of transcription (STATs) are components of an old phylogenetic and highly conserved signal transduction pathway in metazoans. As key elements of the JAK-STAT signal pathway, members of ... -
The association between stress and blood pressure in a sample from the German Health Interview and Examination Survey for Adults (DEGS1)
(2015-07-14)Objective: Psychosocial stressors have long been studied for their contribution to the development of hypertension, but their role remains controversial. In this post-hoc analysis of the nationwide German Health Interview ... -
Charakterisierung von Punktmutationen in der DNA-Bindedomäne des humanen Transkriptionsfaktors STAT1
(2015-02-23)Signal transducer and activator of transcription 1 (STAT1) is a member of the conserved protein family of cytokine-regulated transcription factors and plays a decisive role in many biological processes such as the control ... -
Der Beitrag der SH2-Domäne von STAT1 zur Regulation transkriptioneller Antworten im IFN-Gamma-abhängigen Signalweg
(2014-11-10)The interferon-inducible transcription factor STAT1 (signal transducer and activator of transcription 1) plays an important role in the defense against viral, bacterial and par-asitic infections. Well studied is the ... -
Die Rolle der Linker-Domäne von STAT1 bei der Regulation transkriptioneller Antworten im Interferon-Signalweg
(2013-10-30)Signal transducers and activators of transcription (STATs) constitute an evolutionary highly conserved protein family, which play distinct roles in cytokine signaling. The family member STAT1, probably one of the best-studied ...