Blättern Human- und Zahnmedizin nach "Miosge, Nicolai Prof. Dr." Betreuer
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Die Auswirkungen eines FABP5-Knockdowns in chondrogenen Progenitorzellen
(2017-06-08)Osteoarthritis (OA) is a degenerative disease of the joints in the course of which articular cartilage and surrounding tissues are destroyed. Symptoms range from pain to a complete loss of mobility. Previous therapies aim ... -
Die Bedeutung des Kollagens für die Regeneration der Rotatorenmanschette: Histologische und immunhistologische Untersuchung der Verteilung der Kollagene Typ I, Typ II und Typ III nach single- und double-row-Naht-Anker-Rekonstruktion
(2011-02-17)Introduction: In recent biomechanical studies, the double-row suture anchor reconstruction for surgical treatment of rotator cuff tears showed better biomechanical results when compared to ... -
Bestimmung der Quantität der mRNA ausgewählter Proteine der extrazellulären Matrix des Alveolarknochens mithilfe der real-time RT-PCR
(2017-07-12)The objective is to determine the mRNA quantity of selected proteins of the extracellular matrix in the alveolar bone with the help of real-time RT-PCR. The proteins were selected because of their involvement in remodeling ... -
Cartilage oligomeric matrix protein in der Pathogenese der Arthrosis deformans
(2007-02-12)As a member of the thrombospondin gene family, cartilage oligomeric protein (COMP) is found mainly in the extracellular matrix often associated with cartilage tissue as well as synovia and ... -
Die DDR-1-knockout-Maus – ein neues Tiermodell für Osteoarthritis im Kiefergelenk
(2019-05-29)Temporomandibular Joint Osteoarthritis is a not yet fully understood disease, although many patients are affected by it. For the investigation of the molecular biological and pathophysiological foundations leading to the ... -
Differenzierung mesenchymaler Progenitorzellen aus dem Wurzelzement humaner Zähne und Co-Kultivierung mit PDL-Zellen
(2021-02-22)Periodontitis is a widespread disease of the periodontal ligament: The German Dental Association sees further need in the fifth oral health study for the treatment of periodontal diseases, since every second younger adult ... -
Differenzierungspotenzial humaner primärer Parodontalligament-Zellen von Patienten mit gesundem Zahnhalteapparat
(2022-06-07)The fibrous apparatus of the human periodontium is subject to both structural aging processes and adaptation to functional loads and thus exhibits characteristics of a dynamic system. Structural studies of the parodontal ... -
Der Einfluss der Wachstumsfaktoren TGF-b3 und EGF sowie des Matrixmoleküls Biglycan auf die Gene SOX9 und RUNX2 in chondrogenen Progenitorzellen
(2016-09-09)Osteoarthritis (OA) is a chronic disease of the joints in the human body, especially of the knee joint. It is characterized by inflammatory and degenerative processes that strongly limit patients in their mobility. In the ... -
Einfluss von Interleukin 17 auf chondrogene Vorläuferzellen in der rheumatoiden Arthritis
(2014-02-06)Rheumatoid Arthritis is a chronic inflammatory joint disease of still unknown etiology leading to progressive joint destruction. Immunoregulatory cells, synoviocytes and cartilage cells were previously shown to play an ... -
Der Einfluss von Rab5c auf die Ciliogenese bei chondrogenen Progenitorzellen
(2023-02-15)The primary cilium is gaining increasing importance in research because it is believed that the primary cilium is involved in regulating the differentiation, matrix synthesis potential, and migration of chondrogenic ... -
Einfluss von Wachstumsfaktoren auf die Migration von mesenchymalen Progenitorzellen im menschlichen Kniemeniskus
(2015-07-07)Meniscal Progenitor Cells (MPCs) are a newly established group of progenitor cells found in knee menisci of patients suffering from osteoarthritis. This work compares the influence of three growth factors on the migration ... -
Der Einfluss von YWHAE auf das chondrogene Potenzial von chondrogenen Progenitorzellen
(2020-06-19)The goal of this thesis was to investigate the influence of YWHAE on the chondrogenic potential of chondrogenic progenitor cells (CPC). If it would be possible to enhance their chondrogenic potential, CPCs would be a ... -
Einfluss von Zoledronat und Denosumab auf humane Zellen der osteoblastären Linie aus dem Kieferknochen anhand osteogener Marker
(2023-06-07)Medication-related osteonecrosis of the jaw is a common complication of antiresorptive therapy. Zoledronate and denosumab are the most widely used and potent drugs for antiresorptive therapy, and at the same time are ... -
Die entzündungsmodulierenden Eigenschaften von Adiponektin und Leptin und deren Wirkung auf chondrogene Progenitorzellen
(2016-04-08)Osteoarthritis (OA) and rheumatoid arthritis (RA) belong to the most common forms of arthitis worldwide. They are a major cause of disability, resulting in pain and loss of function. The common aspect of both diseases is ... -
Evaluation des Immunophilins FKBP51 als therapeutisches Ziel in der Therapie der Osteoarthrose
(2023-04-21)Osteoarthritis (OA) is a degenerative disease leading to a destruction of the articular cartilage and the surrounding tissues of the affected joints. In the late stages it cumulates in a complete loss of joint function. ... -
Expressionsanalyse chondrogener Progenitorzellen im ex-vivo Migrationsexperiment
(2015-04-30)The chondrogenic progenitor cells are under control of the expression factors Sox9 and Runx2 favoritising either chondrogenic or osteogenic behavior. In this study we examine the impact on chondrogenic progenitor cells ... -
Funktionen von SMURF1 und SMURF2 in der Differenzierung von chondrogenen Progenitorzellen
(2018-07-09)OA is a degenerative joint disease which is characterized by an increasing loss of joint cartilage. Within this degenerative process OA does not exclusively describe the pathological change of cartilage but rather the ... -
Gewinnung und Charakterisierung von humanen Zementoblasten
(2018-05-14)Root cementum represents one of the crucial prerequisites for an intact fixation in the tooth's osseous socket, the alveole. Healthy cementum and its self-repair mechanisms are furthermore vital to a sound parodontium and ... -
Gewinnung und Charakterisierung von osteoblastären Zellen aus dem humanen Alveolarknochen
(2018-05-14)Osteoblasts represent one of the most important cell groups for bone forming as well as bone structuring and involve essentialy, together with osteoclasts and osteocytes, in the bone metabolism. Their main task, the secretion ... -
Histologische Klassifikation für degenerativ geschädigte Menisken - die Wnt-Signalwegsmoleküle RSPO2 und SFRP2 in humanem Meniskusgewebe
(2014-02-07)This work shows a new histological classification for the degenerative meniscus via alcian blue staining. Speciment were taken from patients, who undergo total knee replacemt operation. We also prove the existance of the ...