Blättern Human- und Zahnmedizin nach "Stadelmann-Nessler, Christine Prof. Dr." Betreuer
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Die neuropathologische Untersuchung von Hautbiopsien bei Patient*innen nach Fume Event bei Verdacht auf eine Small-Fiber-Neuropathie
(2024-04-29)Small-Fiber-Neuropathy (SFN) is a disease of the thinly myelinated A-delta and unmyelinated C-fibers. This results in a reduction of the intraepidermal nerve fiber density. Affected patients predominantly report acral pain ... -
Charakterisierung von BCAS1-positiven Oligodendrozyten während der menschlichen Gehirnentwicklung
(2024-02-05)This work investigated the comparison between different stages of pre- and early postnatal development of oligodendrocytes in the white matter of the central nervous system. The main focus was to aim at BCAS1+ oligodendrocytes ... -
Schwannzell-Remyelinisierung bei Neuromyelitis optica
(2023-11-07)Neuromyelitis optica (NMO) is a chronic, autoimmune inflammatory, astrocyte depleting and demyelinating disease of the central nervous system (CNS) and typically affects the spinal cord (myelitis) and optic nerves (neuritis ... -
Expressionsmuster von EBV mikroRNAs in Hodgkin Lymphomen
(2023-03-24)Epstein-Barr virus encodes 40 different miRNAs with considerable impact on cellular functions of the latently infected cell. In this study EBV miRNA expression patterns in EBV-positive Hodgkin lymphoma and other malignant ... -
Mikroglia-/Makrophagenphänotypen bei humanen Entmarkungserkrankungen (MS, NMO und PML)
(2022-12-14)Multiple sclerosis (MS) is a demyelinating disease of the central nervous system with unknown pathophysiology. Microglia and macrophages accumulate in MS lesions and are discussed as initiators of the cascade of ... -
Charakterisierung der Oligodendroglia in akuten und chronischen Entmarkungsläsionen der Maus
(2022-09-05)MS is a chronic inflammatory autoimmune disease of the CNS of unknown etiology associated with demyelinating lesions. In addition to chronic demyelinated lesions, there are also remyelinated areas in the CNS. Therapeutically, ... -
Histologische Veränderungen von primären ZNS-Lymphomen nach Steroidtherapie im Vergleich zu chronisch-entzündlichen ZNS-Erkrankungen
(2022-04-22)Primary central nervous system lymphomas (PCNSL) can resemble multiple sclerosis (MS) lesions not only clinically and radiologically, but also histologically if they have been pre-treated by glucocorticoids. They then ... -
Die Rolle des mikroglialen Aryl-Hydrocarbon-Rezeptors in der Cuprizon-induzierten toxischen Entmarkung
(2022-03-28)Multiple sclerosis (MS) is an acquired, inflammatory and neurodegenerative, immune-mediated disease of the central nervous system, primarily involving focally accentuated myelin loss. The detailed etiopathogenesis of MS ... -
Zeitverlauf und Therapie axonaler Schädigung bei NMO
(2021-10-25)In this doctoral thesis, the time course of axonal damage and the effect of glutamatergic and purinergic receptor antagonists on acute axon pathology were investigated in the focal experimental NMO rat model for the first ... -
Oligodendrozytenpopulationen in Läsionen der multiplen Sklerose sowie der toxisch- und autoimmun-induzierten Demyelinisierung
(2021-07-21)The objective of the present work was to investigate the density of cells of the oligodendroglial lineage in early lesions of MS patients as well as in animal-derived tissue samples. Demyelination was studied within the ... -
Der Einfluss von Interleukin-3 auf die Läsionslast der experimentellen autoimmunen Enzephalomyelitis
(2018-06-01)Multiple sclerosis is an inflammatory disease of the central nervous system. Despite decades of research its etiology remains unclear. Keeping in mind that experimental autoimmune encephalomyelitis is an artificially induced ... -
Identification of Prognostically Relevant Cellular Markers of Differentiation in Glioblastoma
(2016-09-28)Introduction: Glioblastoma multiforme is the most common primary brain tumor. Despite intense research efforts worldwide, the prognosis of patients diagnosed with this tumor remains poor. Several clinical and molecular ... -
Die Funktion von CX3CR1 in einem spontanen Modell der experimentellen Autoimmunenzephalomyelitis
(2016-08-16)Multiple sclerosis is an inflammatory autoimmune disease of the central nervous system. The best method to reflect the clinically and pathologically heterogeneous disease in animal models is an experimental autoimmune ... -
Auswirkung einer selektiven p75-Neurotrophinrezeptor-Defizienz im Immun- oder Zentralnervensystem auf die experimentelle autoimmune Enzephalomyelitis
(2015-01-29)The clinical manifestation of multiple sclerosis (MS) is largely due to axonal damage and axonal loss caused by inflammation and demyelination. As an explanation for the different extents of axonal damage and thus the ... -
The effect of dopamine and its agonist pramipexole on oligodendrocytes in culture and in the cuprizone mouse model
(2014-02-10)Oligodendrocytes are of crucial importance for the integrity and function of the central nervous system (CNS) as well as for efficacy of signal conduction and thus for brain function itself. They are responsible for axonal ... -
Einfluss des Wachstumsfaktors Fibroblast Growth Factor 9 auf die Remyelinisierung im Cuprizon-Modell der Multiplen Sklerose
(2014-02-03)The objective of this study was to analyze the influence of fibroblast growth factor 9 (FGF-9) on remyelination in a model for multiple sclerosis. Oligodendrozyte death and demyelination were induced in a mouse model by ... -
Die Rolle der Rezeptor-Protein-Tyrosin-Phosphatase Typ ζ bei der De- und Remyelinisierung
(2013-10-11)Multiple Sclerosis (MS) is a chronic autoimmune disease of the central nervous system (CNS) characterized by disruption of the blood-brain barrier, inflammation, demyelination, loss of oligodendrocytes, axonal damage and ... -
Die Bedeutung des p75-Neurotrophinrezeptors während der De- und Remyelinisierung im Cuprizon- Modell der Multiplen Sklerose
(2013-05-30)Multiple sclerosis (MS), the most frequent central nervous system (CNS) autoimmune disease is characterized by multiple focal demyelinated lesions. Partial remyelination of these lesions is frequently observed and considered ... -
Epigenetische Kontrolle der Remyelinisierung bei Multipler Sklerose
(2012-06-15)A great variability of remyelinisation is frequently found in demyelinated plaques of patients with multiple sclerosis (MS). Regarding this variability recent studies have found a correlation between the Histone deacetylase ... -
De - und Remyelinisierung in Dopaminrezeptor-defizienten Mäusen
(2012-05-31)De-and remyelination in dopamine receptor-deficient mice Multiple sclerosis (MS) is an inflammatory demyelinating disease of the central nervous-system with destruction of myelin sheaths, axonal damage and only ...