Browsing Human- und Zahnmedizin by Referee "Legler, Tobias Prof. Dr."
Now showing items 1-18 of 18
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Anämien bei chronisch entzündlichen Darmerkrankungen und die mögliche Bedeutung von Erythropoetin (EPO) - Eine retrospektive Analyse des Göttinger mit Anti-TNF-alpha-Antikörpern behandelten Patientenkollektivs -
(2021-02-25)Anti-tumor necrosis factor (TNF) therapy has improved the medical treatment of inflammatory bowel diseases (IBD), Crohn’s disease (CD), and ulcerative colitis (UC). The TNF-blocker Infliximab® is widely used as a effective ... -
Bedeutung der mikrobiellen Transmission im SIV-Rhesusaffen-Tiermodell für die HIV/AIDS-Pathogenese
(2011-02-18)Chronic immune activation is a major aspect of HIV infection and AIDS pathogenesis. Recent data suggests that immune activation is mainly caused by translocation of microbial products through ... -
Chairside-Nachweis aktivierter Matrixmetalloproteinase-8 (aMMP-8) sowie Detektion potenziell parodontalpathogener Bakterien zur parodontalen Risikoeinschätzung in der Blutspende
(2017-12-06)The aim of this clinical cross-sectional study was to find out whether an aMMP-8 point-of-care test is adequate for chairside identification of periodontally diseased patients by the transfusion medic. Furthermore it was ... -
Charakterisierung und Bedeutung extrazellulärer Vesikel im Blut von Patienten mit soliden Tumoren
(2023-07-18)The goal of the study was to analyse tumour-associated extracellular vesicles in the blood of patients with solid tumour diseases and their connection with the clinical progress of the diseases. The vesicles of 330 ... -
Dentaler und parodontaler Mundgesundheitszustand von Blutspendern in der Transfusionsmedizin: Ergebnisse einer klinischen Querschnittstudie
(2019-06-04)Aim: The aim of this clinical cross-sectional study was to evaluate the oral health status and behavior of blood donors. In addition, it was investigated whether an association between the local infection periodontitis and ... -
Einfluss von Bluttransfusionen auf das Outcome von Patienten mit Sepsis
(2024-01-29)Despite modern medical care, sepsis remains an issue, especially for the aging society with an increasing number of multimorbid patients. The group of sepsis patients shows large heterogeneity and there are numerous factors ... -
Der Einfluß von Leptin auf die Freisetzung endothelialer Vorläuferzellen aus dem Knochenmark
(2014-06-25)Objective− Bone marrow progenitor cells participate in new vessel formation and endothelial repair, and both processes may be modulated by the adipokine leptin. The leptin receptor (ObR) is expressed on hematopoeitic cells, ... -
Epigenetische Veränderung von zirkulierender Tumor-DNA im Ethylendiamintetraessigsäure (EDTA)-Plasma von Mammakarzinompatienten
(2021-11-22)This proof-of-concept study with the title “Epigenetic alteration of circulating tumor DNA in the ethylenediaminetetraacetic acid (EDTA) plasma of breast cancer patients” discussed whether hypermethylated gene sequences ... -
Etablierung eines Verfahrens zum Nachweis epigenetischer Biomarker im peripheren Blut zur Stratifizierung der Therapie des Rektumkarzinoms
(2015-12-08)Bisulfite treatment based assays are mainly used to detect aberrant, tumor specific methylation of specific DNA regions either from tissue or from free circulating DNA in plasma or serum. Since bisulfate based protocols ... -
Extrakorporale Photopherese mit UVC-behandelten Leukozyten im Vergleich zu 8-MOP/UVA-behandelten Leukozyten zur Therapie der akuten graft-versus-host disease im Mausmodell
(2022-02-28)Graft-versus-host disease (GvHD) is a complication after allogeneic hematopoietic stem cell transplantation and responsible for the high morbidity and mortality rate. Extracorporeal photopheresis (ECP) is a common second-line ... -
Häufigkeit und Auswirkungen der ASS Non-Response bei kardiochirurgischen Patienten
(2018-01-04)Coronary artery disease (CAD) is accompanied with high morbidity and mortality that can be treated with a revascularization procedure. Nearly all patients receive acetylsalicylic acid (ASA) for secondary prevention of major ... -
Inhibition des microRNA-Clusters 17-92 als mögliche Leukämietherapie
(2017-09-29)The dysregulation of microRNAs appears to be a crucial factor in leukemia. Therefore, therapies might be possible that target the altered expression of proliferation-regulating microRNAs. The microRNA cluster 17-92 was ... -
Kinetik von NK-Zellen und gamma-delta-T-Zellen nach Infektion von Rhesusaffen mit Immundefizienzviren
(2010-07-15)Die HIV-Infektion und AIDS entwickelten sich in den letzen 25 Jahren zur Pandemie. 2006 waren rund 39 Millionen Menschen mit HIV infiziert. Das aussagekräftigste Modell für die Erkrankung ... -
Niedermolekulares und unfraktioniertes Heparin als Therapeutika der akuten Graft-versus-Host Disease im Mausmodell
(2021-11-09)Acute graft-versus-host disease (aGvHD) is a common complication after allogeneic hematopoietic stem cell transplantation for which only limited therapeutic options are available. Numerous published studies have shown an ... -
Phänotypische Charakterisierung humaner Monozyten von Blutspendern mit chronischer Toxoplasmose und nicht-infizierten Kontrollen
(2020-11-13)The globally distributed parasite Toxoplasma gondii (T. gondii) is an obligatory intracellular protozoan and the infectious agent of toxoplasmosis in humans and animals. Humans become regularly infected by ingestion of ... -
Progenitorzelleigenschaften bei myelodysplastischen Syndromen (MDS) mit Eisenüberladung
(2011-10-07)In patients with myelodysplastic syndromes (MDS) iron overload caused by long term red blood cell transfusions is an important factor for comorbity. In this report we present the results ... -
Untersuchung des Einflusses von Leptin auf die Thrombozytenfunktion sowie Analyse der Leptin-vermittelten Signalkaskade in Thrombozyten
(2015-03-04)Obesity is an increasing problem in industrial countries. It is an independent risk factor for the development of different diseases like stroke, pulmonary embolism, and myocardial infarction. Cardiovascular diseases are ... -
UVC als Alternative zur 8-MOP / UVA-Behandlung in der extrakorporalen Photopherese
(2020-02-07)Background Graft-versus host complications and other (auto-)immune diseases are successfully treated with Extracorporeal Photopheresis (ECP), a widely accepted cellular therapy. The international standard for the ex vivo ...