Browsing Human- und Zahnmedizin by Referee "Miosge, Nicolai Prof. Dr."
Now showing items 1-20 of 53
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Eigenschaften chondrogener Progenitorzellen mit RAB5C-Knockout
(2024-07-03)Osteoarthritis is one of the most prominent civilization diseases due to its wide prevalence. Current therapies mainly focus on various symptomatic and rehabilitative approaches, as causal therapies are still lacking. ... -
Einfluss von Zoledronat und Denosumab auf humane Zellen der osteoblastären Linie aus dem Kieferknochen anhand osteogener Marker
(2023-06-07)Medication-related osteonecrosis of the jaw is a common complication of antiresorptive therapy. Zoledronate and denosumab are the most widely used and potent drugs for antiresorptive therapy, and at the same time are ... -
Der Einfluss von Rab5c auf die Ciliogenese bei chondrogenen Progenitorzellen
(2023-02-15)The primary cilium is gaining increasing importance in research because it is believed that the primary cilium is involved in regulating the differentiation, matrix synthesis potential, and migration of chondrogenic ... -
Therapeutischer Nutzen einer mitochondrialen Katalase-Expression in einem Mausmodell des Rett-Syndroms
(2021-10-05)Rett syndrome is a severe neurodevelopmental disorder that mainly affects girls with a prevalence of 1: 10,000 to 1: 15,000. The clinical symptoms are complex and are characterized by cognitive impairment, irregular ... -
Onkologische und funktionelle Ergebnisse verschiedener Therapiestrategien bei Plattenepithelkarzinomen der Subglottis
(2021-09-16)Approximately 5 % of laryngeal carcinoma is located in the subglottis, making it a rare tumor site for which only few studies exist. Primary subglottic tumors are usually asymptomatic or symptoms occur late therefore the ... -
Assoziationen von krankheits- und therapiebezogenen Parametern sowie Einfluss von Serum-IL-6- und IL-10-Spiegeln bei Patienten mit Parodontitis und rheumatoider Arthritis unter immunsuppressiver Therapie
(2021-09-06)The aim of this study was to record clinical periodontal findings according to disease activity (clinical and serological) in patients with rheumatoid arthritis (RA). Furthermore, the influence of different immunosuppressive ... -
Bioaktivität und physikochemische Eigenschaften von mit funktionalisierten Silica-Nanopartikeln versetzten Universaladhäsiven
(2021-06-10)Objectives: This study aims to analyze the effect of methacrylate polyhedral oligomeric silsesquioxane (POSS-8, Hybrid Plastics, Inc., Hattiesburg,USA) particles on the polymerization process, shear bond strength and ... -
Differenzierung mesenchymaler Progenitorzellen aus dem Wurzelzement humaner Zähne und Co-Kultivierung mit PDL-Zellen
(2021-02-22)Periodontitis is a widespread disease of the periodontal ligament: The German Dental Association sees further need in the fifth oral health study for the treatment of periodontal diseases, since every second younger adult ... -
Radiomorphometrische Untersuchung der Knochenregeneration in vivo durch kombinierte Freisetzung von VEGF und BMP aus den PDLLA/CaCO3-Komposit-Scaffolds.
(2021-02-22)Bone regeneration of critical-size defects requires ideal release on time of growth factors. The aim of the present in vivo study on male Wistar rats was to improve bone regeneration in mandibular defects of critical-size ... -
Untersuchung der Freisetzungskinetik unterschiedlicher mit rh-BMP-2 beladener Polyelektrolyt-Multilayer-Schichten auf Titanplättchen
(2021-01-15)The aim of this in vitro study was to investigate the release kinetics of rh-BMP-2 from polyelectrolyte multilayers on titanium platelets of different modifications. The heparin PEM showed sufficient loading of rh-BMP-2 ... -
Der direkte und indirekte Effekt von Zytokinen bei Morbus-Crohn-Patienten auf die Differenzierung von Osteoklasten - Effekt unter besonderer Berücksichtigung von TNF-α, Interleukin-1ß und Interleukin-6 -
(2020-10-20)Crohn's disease is associated with an increased prevalence of osteoporosis and fractures whose pathogenesis is still controversial. However, among the most important influences, the disease activity, in particular the ... -
Knochenregeneration chronischer Knochendefekte der porcinen Maxilla unter kombinierter Freisetzung von rhBMP-2 und rhVEGF-A165 aus PDLLA/CaCO3-composite-Granula
(2020-10-09)The functional aesthetic reconstruction of facial bone defects is one of the challenging aspects in oral and maxillofacial surgery. Free avascular or anastomosed bone grafts are the current gold standard of reconstruction. ... -
Physikochemische und bioaktive Eigenschaften von mit Methacryl-funktionalisierten Silica-Nanopartikeln modifizierten experimentellen Adhäsiven
(2020-05-25)Aim: The aim of the study was to investigate the physico-chemical and bioactive properties of experimental dental adhesives containing methacryl-functionalized polyhedral oligomeric silsesquioxane (MA-POSS-8). Methods: ... -
Einfluss der kombinierten Freisetzung von rhBMP-2 und rhVEGF165 aus PDLLA/Calciumcarbonat-Gerüsten auf die In-vitro-Aktivität der Osteogenese und Angiogenese
(2018-05-28)The replacement of bony structures is part of the clinical routine of oral and maxillofacial surgery. The choice of method and substitute material depends on several factors: the current and long-term mechanical strength ... -
Gewinnung und Charakterisierung von osteoblastären Zellen aus dem humanen Alveolarknochen
(2018-05-14)Osteoblasts represent one of the most important cell groups for bone forming as well as bone structuring and involve essentialy, together with osteoclasts and osteocytes, in the bone metabolism. Their main task, the secretion ... -
Gewinnung und Charakterisierung von humanen Zementoblasten
(2018-05-14)Root cementum represents one of the crucial prerequisites for an intact fixation in the tooth's osseous socket, the alveole. Healthy cementum and its self-repair mechanisms are furthermore vital to a sound parodontium and ... -
Angiogene Auswirkung der retardierten Freisetzung von rh-BMP-2 und rh-VEGF im Muskel der Ratte. Immunhistochemische Auswertung von CD31 und CD34
(2018-01-23)Bone defects of the facial skull are associated with a extensive amount of treatment. In therapy, the focus is not only on the functional reconstruction, but also on a satisfactory aesthetic rehabilitation for the ... -
Effekte von Zoledronat auf die Genexpression von RANKL sowie auf die histomorphometrische Knochenstruktur des Göttinger Minischweins
(2018-01-04)The aim of the present study, entitled "Effects of zoledronate on the gene expression of RANKL as well as on the histomorphometric bone structure of the Göttinger Minipig" was the molecular-biological examination of the ... -
μCT-Untersuchung sowie histologische Auswertung zur Knochendichte- und -dickenmessung der subchondralen Kompakta bei Osteoarthrose des Menschen
(2017-11-15)GOAL The aim of this in-vitro study was the μCT based determination of subchondral solid bone thickness and its degree of mineralization in specimens of knees resected in reconstructional orthopaedic surgery from human ... -
Bestimmung der Quantität der mRNA ausgewählter Proteine der extrazellulären Matrix des Alveolarknochens mithilfe der real-time RT-PCR
(2017-07-12)The objective is to determine the mRNA quantity of selected proteins of the extracellular matrix in the alveolar bone with the help of real-time RT-PCR. The proteins were selected because of their involvement in remodeling ...