Browsing Human- und Zahnmedizin by Referee "Thumm, Michael Prof. Dr."
Now showing items 1-12 of 12
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Neuronal glucose metabolism in amyotrophic lateral sclerosis
(2024-06-28)ALS is a rapidly progressing neurodegenerative disease characterized by motor neuron death ultimately leading to paralysis and respiratory failure. While a great deal of progress has been made deciphering the underlying ... -
Activity-dependent turnover of the Perineural Extracellular Matrix
(2024-04-05)The different molecules present in the extracellular space of the brain make-up the perineural extracellular matrix (ECM). One of the specializations of the perineural ECM, the perineural nets (PNNs), are lattice-like ... -
Elucidating the role of BEACH domain-containing proteins, which are mutated in several diseases, using a simple eukaryotic model organism, Saccharomyces cerevisiae
(2022-05-10)Mutations in BEACH domain-containing proteins (BDCPs) cause various human diseases, such as the Chediak-Higashi syndrome, the generalised autoimmunity syndrome or the gray platelet syndrome. Furthermore, a variety of other ... -
Extracellular vesicles derived from adipose mesenchymal stem cells (AMSCs) reduce autophagic flux via microRNA-25-3p transfer after ischemic stroke
(2022-03-03)Causal therapy of ischemic stroke remains available to only a minority of patients despite the success of systemic thrombolysis and thrombectomy. Consequently, new adjuvant therapeutic options are urgently needed. MSC ... -
Role of autophagic protein ULK1 in axonal degeneration and regeneration in rat cortical neurons in vitro
(2021-11-02)In many traumatic and neurodegenerative disorders of the central nervous system, axonal degeneration is a central and early pathophysiological feature. Since the regenerative response of injured neurons is severely hampered ... -
Identifizierung von neuen Komponenten oder Cargoes der COPI Vesikelhüll Maschinerie
(2021-03-26)Within the cell transport vesicles play an essential role in ensuring the functionality of the cell. The heptamere COPI is responsible for transport from the Golgi to the endoplasmic reticulum and also for transport between ... -
Cysteine residues of the mammalian GET receptor: Essential for tail-anchored protein insertion?
(2017-05-17)Tail-anchored proteins integrate into lipid bilayers via a single transmembrane segment at their extreme C-terminus. The membrane insertion step is mediated by a heterodimeric receptor complex formed by WRB and CAML in ... -
Die Bedeutung der Deubiquitinase OTUD4 in Bezug auf die Tumorprogression epithelialer Tumoren
(2016-08-24)Die Grundannahme dieser Arbeit war, dass OTUD4 als Deubiqutinase die Funktion der Demethylase ALKBH3 stabilisiert, indem es den proteasomalen Abbau von ALKBH3 durch Deubiquitinierung verhindert. Um diese Annahme zu ... -
Peroxisomes and Kidney Damage
(2014-12-12)This work examined (a) how the endotoxic stress affects peroxisomal function and autophagic degradation of peroxisomes-pexophagy, (b) how a superimposed dysfunction of lysosomes and pexophagy modifies responses to ... -
Entwicklung und Evaluation eines neuen Modells für Synucleinopathien
(2013-11-19)Missfolding and oligomerization of alpha-synuclein is considered a central event in different neurodegenerative diseases like Parkinson’s disease and related disorders. As the function of alpha-synuclein is still a matter ... -
Die Organisation von Signalnetzwerken in B-Lymphozyten
(2012-07-17)B cell antigen receptors (BCR) transduce signals that regulate not only proliferation and differentiation processes but also apoptosis. To regulate such a variety of biological responses BCR employ complex and tightly ... -
Pathomechanismen der sporadischen Einschlusskörpermyositis: molekulare Interaktionen zwischen Autophagie, Zellstress und Akkumulation von beta-Amyloid im Skelettmuskel
(2012-02-07)Sporadic Inclusion Body Myositis (sIBM) is a chronic progressive, inflammatory myopathy, which in addition to polymyositis, dermatomyositis and necrotizing myopathy belongs to the group of ...