Browsing Human- und Zahnmedizin by Referee "Walter, Lutz Prof. Dr."
Now showing items 1-16 of 16
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Analysis of teriflunomide therapy on EAE
(2022-01-31)Multiple sclerosis (MS), the most common autoimmune disorder of the CNS, is characterized by the infiltration of autoreactive inflammatory cells. Nowadays, more and more immune modulating drugs are entering the European ... -
Einfluss des Integrins α E (CD103) auf das allergische Kontaktekzem bei Mäusen
(2021-07-15)Allergic contact dermatitis is a dermatologic disease that affects both children and adults and has a high prevalence due to the variety of potential contact allergens. In most cases, it is based on a late-type allergic ... -
Neutrophil Extracellular Traps (NETs) in der Interleukin-23-induzierten psoriasiformen Dermatitis
(2021-07-14)Psoriasis is a chronic recurrent inflammatory disease of the skin and joints, often associated with significant morbidity. In spite of its clinical importance, the pathogenesis of psoriasis is not fully understood. Recently, ... -
Allergische und irritative Kontaktdermatitis in Filaggrin- und Hornerin-defizienten Mäusen
(2020-10-13)The two epithelial structural proteins filaggrin (Flg) and hornerin (Hrnr) play a major role in upholding the integrity of the skin barrier function. Loss-of-function mutations in these genes cause an epidermal barrier ... -
Strukturelle und funktionelle Charakterisierung Filaggrin/Hornerin defizienter (FlgHrnr-/-) Mäuse
(2020-02-14)Filaggrin (Flg) and hornerin (Hrnr) share similar structural and functional features. Both proteins have been implicated as essential proteins for skin barrier maintenance. Loss-of-function mutations of these genes constitute ... -
Identifikation und funktionelle Charakterisierung von TMPRSS2-Spaltstellen im Spike-Protein des SARS-Coronavirus
(2017-04-24)The severe acute respiratory syndrome coronavirus (SARS-CoV) is an emerging pathogen, which poses a substantial threat to human health. The viral surface protein spike (SARS-S) mediates viral entry into target cells. The ... -
Anti-inflammatorische Wirkung des inositoylierten Plättchen-aktivierenden Faktors (Ino-C2-PAF) in vitro und in vivo
(2016-12-21)With a prevalence of 1-3% psoriasis is one the most common chronical inflammatory skin diseases. Histopathological findings are an epidermal hyperkeratosis and acanthosis furthermore an increased angiogenesis and a mixed ... -
Klonierung der Genomsegmente des Oropouche-Virus und Charakterisierung der Interferon-antagonistischen Aktivität des S-Segment-kodierten NSs-Proteins
(2015-01-27)Abstract: Oropouche virus (OROV) is a human-pathogenic member of the genus orthobunyavirus within the family Bunyaviridae. Until now, neither an effective antiviral treatment for the dengue fever-like disease caused by ... -
Untersuchungen zur Funktion des tripartite-motif-22 (TRIM22)-Proteins
(2013-11-11)TRIM22 is an intracellular protein that has previously been shown to exhibit manifold functions in human cells. TRIM22 is described to have antiviral potential, may function as an ubiquitin E3 ligase and is described to ... -
Charakterisierung der Eigenschaften der nichtkodierenden Enden der Genomsegmente des Oropouche-Virus und ihre Bedeutung für die virale Transkription/Replikation sowie die Interaktion mit dem Typ-I-Interferonsystem
(2013-07-25)The Oropouche virus (OROV) is a RNA virus from the Bunyaviridae family. Its genome consists of a single-stranded negative sense RNA. The Oropouche fever is caused by this virus and is most common in Central and South ... -
Untersuchung zur Existenz des Melanocortin-4-Rezeptors im Lebergewebe von Wistarratten und die Veränderung der Genexpression auf RNA- und Proteinebene unter Induktion einer Akut-Phase-Reaktion mittels Terpentinöl
(2012-08-02)The liver as a central metabolic organ and part of the body’s own immune defence is inextricably linked with the acute phase reaction (APR) of a systemic immune reaction. Especially with respect to the breakdown of toxic ... -
Engineering of a bifunctional anti-Kv10.1 antibody for cancer therapy
(2011-10-26)Antibody-based cancer therapy uses the high specificity of antibodies to selectively destroy cancer cells. Therefore, a chief factor for an efficient antibody-based cancer therapy is the ... -
Anzucht, Aufreinigung und partielle Charakterisierung von Kleinen Virus-ähnlichen Partikeln des JC-Virus
(2011-09-05)Virus-like particles are viral capsids without virus-specific nucleid acids. They are produced by recombinant expression of the structural proteins of the virus and are free of viral nucleid ... -
Bedeutung des löslichen CD14-Rezeptors in Plasma und Urin als immunologischer Parameter nach Nierentransplantation und sein Verhältnis zu den löslichen Rezeptoren IL2R, CD4 und CD8
(2011-05-02)The soluble CD14 (sCD14) is increased in plasma during an immunological activation. For patients following kidney transplantation the avoidance or early detection and treatment of complications ... -
Selbsttoleranz von NK-Zellen
(2011-02-01)In 2005 nk cells were detected in the murine model, which do not express any known HLA-specific inhibitory receptor. These findings contradict the current "at-least-one" model in which the ... -
Zytokinrezeptorpolymorphismen bei Patienten mit T-Non-Hodgkin-Lymphomen
(2011-01-31)Specific variations in cytokine genes are associated with the susceptibility and prognosis of Lymphomas. In this study, the association between T-Cell-Lymphomas (T-NHL) and polymorphisms ...