Dokumente Fakultät für Biologie und Psychologie (inkl. GAUSS) nach Erscheinungsdatum
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Characterization of the invasion of hematopoietic myeloid cells into the CNS during EAE
(2022-12-01)Experimental autoimmune encephalomyelitis (EAE), the classical animal model of multiple sclerosis, is caused by T cells directed against myelin antigens. Upon intravenous transfer, these cells appear in the vessels of the ... -
Emergent processes as means of uncertainty reduction in group decision making
(2022-11-29)This dissertation investigates how emergent processes can reduce uncertainty in group decision making.Emergent processes are processes that arise from individual characteristics and social interactions and result in higher ... -
Investigation on the molecular factors driving the formation of distinct tau 'strains'
(2022-11-28)Pathological aggregation of the microtubule-binding protein tau into amyloid fibrils is a hallmark of different neurodegenerative diseases collectively termed tauopathies. To date, tau amyloid structures associated with ... -
The structure of coastal invertebrate communities and their temporal and spatial dynamics
(2022-11-22)The Wadden Sea is one of the largest tidal flats in the world, stretching across the coasts of the Netherlands, Germany and western Denmark. Along sheltered coastlines lie salt marshes which are essential habitats for a ... -
An interdisciplinary perspective on personality
(2022-10-13)In this dissertation I approach the question of why individuals differ from in each other in their behavioural dispositions from an interdisciplinary perspective that builds upon previous work from the disciplines of ... -
Mechanisms of homologous chromosome synapsis and recombination in mammalian meiosis
(2022-10-13)Homologous chromosome synapsis and recombination are key events that occur during meiotic prophase and result in the formation of chromatin structures called chiasmata. These chromatin structures physically connect ... -
Characterization of proneural bHLH transcription factor target genes in X. laevis
(2022-09-23)Zc3h12c is a member of the Zc3h12 endoribonuclease family (also known as MCPIP/Regnase), which contains four members (Zc3h12a-c). This family of proteins is characterized by the presence of a single centrally located ... -
The role of causal representations in moral judgment
(2022-09-05)Morality and causation are deeply intertwined. For instance, the value of anticipated consequences is a crucial input for an action’s moral permissibility, and assigning blame or responsibility for outcomes generally ... -
The Moral Permissibility of Killing in War: An Experimental Approach to the Moral Judgment of Side-Effect and Defensive Killing
(2022-09-05)In wars combatants face situations that challenge their moral compass. They may, for example, have to decide whether to pursue military victories to protect their community at the cost of harming innocents. They must also ... -
Cell type specific transcriptomic characterization of myelin abnormalities
(2022-08-22)Myelin is indispensable for the fast and efficient transmission of electric signals along axons. The formation of myelin by oligodendrocytes in the central nervous system (CNS) is tightly regulated at the transcriptional ... -
Investigating chemical crosslinking of protein-RNA complexes by mass spectrometry
(2022-08-12)RNA plays a quintessential role in cellular processes such as gene expression, transcription, RNA processing, and translation. Proteins carrying out those diverse functions are inherently flexible to accommodate dynamic ... -
Biochemical characterization of human shieldin complex
(2022-08-01)Shieldin is a newly identified DNA repair effector involved in repair of double strand breaks (DSBs) in G1 phase of cell cycle. Shieldin is a four-component complex consisting of proteins SHLD1, SHLD2, SHLD3 and HORMA REV7. ... -
HORMA domain proteins in Autophagy initiation
(2022-08-01)The autophagic pathway is an evolutionarily conserved strategy among eukaryotic cells for maintaining cell homeostasis at the basal level and during stressful conditions. It removes protein aggregates, damaged organelles, ... -
Bioinformatic analysis of multi-omics data elucidates transcriptional cyclin dependent kinase mediated transcriptional regulation
(2022-08-01)Transcriptional regulation is a highly dynamic biological process which is governed by a complex network of proteins for precise expression of a gene. One of the most important regulators of gene expression are cyclin ... -
Untersuchungen zur Rolle von Mph1 aus Saccharomyces cerevisiae und seines menschlichen Orthologen FANCM bei der Erhaltung der genomischen Integrität
(2022-07-22)Living is life-threatening. Cells can only endure the diverse exogenous and endogenous attacks on their genome because they are equipped with a network of coordinated security measures: the DNA damage response. Repair ... -
Entwicklung eines soziotechnischen Gestaltungsmodells für die Arbeit mit Kollaborationsplattformen
(2022-07-19)This dissertation examines the introduction and use of collaboration platforms in companies. Thus, this thesis is a research contribution to the topic of digitization of work. An investigation of collaboration platform use ... -
Improving electron microscopic hardware to push the resolution limits in single particle cryo-EM
(2022-07-19)Electron cryomicroscopy (cryo-EM) is a powerful tool in structural biology for determining 3D structures of macromolecular complexes. In the previous decade, many technological advancements have been introduced to improve ... -
Nucleo-cytoplasmic shuttling of snoRNAs in Saccharomyces cerevisiae
(2022-07-19)Small nucleolar RNAs (snoRNAs) are a group of small non-coding RNAs involved in the post-transcriptional modification of RNAs, such as rRNA and tRNA. The importance of their role is evidenced by the rRNA regions subject ... -
Understanding Transcriptional Control During Primordial Germ Cell Differentiation
(2022-07-08)AP2γ, encoded by Tfap2c, is a transcription factor which both represses and activates target gene expression. It is required for the survival of the early mouse embryo; depending on the context of its depletion, the loss ... -
Biophysical characterization and computational modeling of phase separation of immune adapter proteins
(2022-07-07)The processes of B cell activation and development are stimulated by antigen binding to the B cell receptor. Pre-signaling clusters are present in unstimulated, resting B cells and assemble by tripartite phase separation ...