Dokumente Fakultät für Biologie und Psychologie (inkl. GAUSS) nach Erscheinungsdatum
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HORMA domain proteins in Autophagy initiation
(2022-08-01)The autophagic pathway is an evolutionarily conserved strategy among eukaryotic cells for maintaining cell homeostasis at the basal level and during stressful conditions. It removes protein aggregates, damaged organelles, ... -
Bioinformatic analysis of multi-omics data elucidates transcriptional cyclin dependent kinase mediated transcriptional regulation
(2022-08-01)Transcriptional regulation is a highly dynamic biological process which is governed by a complex network of proteins for precise expression of a gene. One of the most important regulators of gene expression are cyclin ... -
Biochemical characterization of human shieldin complex
(2022-08-01)Shieldin is a newly identified DNA repair effector involved in repair of double strand breaks (DSBs) in G1 phase of cell cycle. Shieldin is a four-component complex consisting of proteins SHLD1, SHLD2, SHLD3 and HORMA REV7. ... -
Untersuchungen zur Rolle von Mph1 aus Saccharomyces cerevisiae und seines menschlichen Orthologen FANCM bei der Erhaltung der genomischen Integrität
(2022-07-22)Living is life-threatening. Cells can only endure the diverse exogenous and endogenous attacks on their genome because they are equipped with a network of coordinated security measures: the DNA damage response. Repair ... -
The confused flour beetle, Tribolium confusum A model for investigating Wolbachia-host interactions
(2022-07-20)Summary Wolbachia, a group of maternally inherited intracellular endosymbiotic Alphaproteobacteria, are found in a wide range of arthropods and nematodes. It has been estimated that over 65% of insect species are infected ... -
Entwicklung eines soziotechnischen Gestaltungsmodells für die Arbeit mit Kollaborationsplattformen
(2022-07-19)This dissertation examines the introduction and use of collaboration platforms in companies. Thus, this thesis is a research contribution to the topic of digitization of work. An investigation of collaboration platform use ... -
Improving electron microscopic hardware to push the resolution limits in single particle cryo-EM
(2022-07-19)Electron cryomicroscopy (cryo-EM) is a powerful tool in structural biology for determining 3D structures of macromolecular complexes. In the previous decade, many technological advancements have been introduced to improve ... -
Nucleo-cytoplasmic shuttling of snoRNAs in Saccharomyces cerevisiae
(2022-07-19)Small nucleolar RNAs (snoRNAs) are a group of small non-coding RNAs involved in the post-transcriptional modification of RNAs, such as rRNA and tRNA. The importance of their role is evidenced by the rRNA regions subject ... -
Understanding Transcriptional Control During Primordial Germ Cell Differentiation
(2022-07-08)AP2γ, encoded by Tfap2c, is a transcription factor which both represses and activates target gene expression. It is required for the survival of the early mouse embryo; depending on the context of its depletion, the loss ... -
Biophysical characterization and computational modeling of phase separation of immune adapter proteins
(2022-07-07)The processes of B cell activation and development are stimulated by antigen binding to the B cell receptor. Pre-signaling clusters are present in unstimulated, resting B cells and assemble by tripartite phase separation ... -
Functional imaging of the anesthetized brain in primates and rodents
(2022-07-05)Understanding the brain is aided by visualizing neural activity over time. The most popular method for doing so in humans is functional magnetic resonance imaging (fMRI)—a method that tracks blood oxygenation as a proxy ... -
A healthy social life? Sociality and health indicators in wild red-fronted lemurs
(2022-06-29)In the last 40 years, an increasing number of studies from medicine, neurosciences, and psychology demonstrated links between many aspects of sociality, health, and fitness in humans and laboratory animals. Some studies ... -
Characterization and development of bacteriophytochrome-derived near-infrared fluorescent proteins for the application in super-resolution microscopy
(2022-06-29)The developments of fluorescence microscopy techniques has advanced our understanding of biological systems on a cellular level. In recent years, several super-resolution microscopy techniques overcame the diffraction ... -
Vitality of heather (Calluna vulgaris) along gradients of climate, structure and diversity in dry lowland heathland habitats of Northern Germany
(2022-06-29)This thesis provides a fundamental overview to North German Dry lowland heathland vegetation composition, vegetation structures and the determinants for the vitality of the key species, Calluna vulgaris. It offers new ... -
Biodiversity Governance: Non-State and Sub-National Initiatives in Latin America
(2022-06-21)Non-state and sub-national actors have been increasingly taking action to address biodiversity loss, however, only relatively recently their initiatives started being integrated into international biodiversity governance. ... -
Decision-Making During Ongoing Actions
(2022-06-21)Contemporary theories of action-based decision-making suggest that making decisions between goods, and specifying the actions required to obtain these goods, are parallel and intertwined processes, which allows for highly ... -
Seasonal habitat use and breeding performance of the Eurasian Skylark (Alauda arvensis) in Central European farmland
(2022-06-21)The Common Agricultural Policy (CAP) of the European Union has often been identified as a driver of recent agricultural intensification and thus of biodiversity loss. All major taxa, including vascular plants, arthropods, ... -
The role of RNA in synapse physiology and neurodegeneration in models of Parkinson’s disease
(2022-06-14)Synaptic dysfunction is an early alteration in multiple neurodegenerative disorders. Parkinson’s disease (PD) is characterised by the accumulation of α-synuclein (αsyn) in pathological inclusions known as Lewy bodies ... -
Anti-apoptotic and neuroprotective erythropoietin/CRLF3-signalling in insects and humans
(2022-06-14)The cytokine receptor like factor 3 (CRLF3) evolved together with the eumetazoan nervous system and is present in all major groups of Animalia. Based on sequence similarities, CRLF3 was assigned to the family of class 1 ... -
Regulation of mechanical feedback amplification in the Drosophila ear
(2022-06-09)Ears achieve their exquisite sensitivity using positive mechanical feedback (Ashmore et al., 2010). Like pushing a swing augments its swing, sound-induced vibrations are enhanced by motile responses of auditory receptor ...