Browsing Fakultät für Biologie und Psychologie (inkl. GAUSS) by Referee "Pöggeler, Stefanie Prof. Dr."
Now showing items 1-20 of 41
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A novel rRNA quality control function for Npl3 in Saccharomyces cerevisiae
(2024-03-25)In all domains of life, ribosomes are essential complexes that are the sole source for protein synthesis. Ribosome biosynthesis, the most energy-consuming process in a cell, has to be tightly regulated. Misregulation ... -
Adhesion of the rapeseed pathogen Verticillium longisporum to its host Brassica napus: Uncovering adhesion genes and the evolutionary origin of the fungus
(2011-05-06)Verticillium longisporum, a soil-borne plant pathogen, is an emerging problem for oilseed rape and other crucifers. The mechanism of infection through plant roots and the evolutionary origin of this fungus are still not ... -
Alterations in gene expression and secondary metabolite production during development of Aspergillus nidulans
(2014-02-10)Many studies describing development and secondary metabolism of the filamentous fungus Aspergillus nidulans contributed to a better understanding of fungal secondary metabolism regulation at the molecular level. However, ... -
Analyse der UPR vermittelten Stressantwort und ihrer Funktion während der biotrophen Entwicklung von<i> Ustilago maydis</i>
(2016-12-09)The unfolded protein response (UPR) is a conserved eukaryotic signaling network that is activated by accumulation of misfolded proteins in the endoplasmic reticulum (ER) to ensure protein homeostasis. In the baker's yeast ... -
Analyse des Kreuzungstyp-Locus des filamentösen Ascomyceten Sordaria macrospora
(2010-12-06)Sex as a mechanism for the exchange of genetic material between individuals is a broadly conserved and tightly regulated process in different species. In the class of ascomycetes the ... -
Analyses of the Life Cycle of TLC1 and the Nuclear RNA Quality Control System in Saccharomyces cerevisiae
(2015-04-24)During genome replication, chromosomes undergo a progressive shortening of their ends. To counteract this loss, a complex named telomerase functions as a reverse transcriptase to elongate telomeres. In Saccharomyces ... -
Analysis of Neuronal Diseases in the Model Organism <i>Aspergillus nidulans</i>
(2008-12-11)Neuronal diseases can include abnormal aggregation of key proteins or the dysfunction of transport processes during the development of nerve cells. Parkinson s disease (PD) is a neurodegenerative ... -
Analysis of the role of Mdm38 in respiratory chain biogenesis
(2011-07-25)The present work illuminates the role of the mitochondrial protein Mdm38 in the biogenesis of the respiratory chain of the yeast Saccharomyces cerevisiae. It is a homolog of the human LETM1, ... -
Assessment of antibiotic resistance in soil and its link to different land use types and intensities
(2020-07-15)Nowadays, bacterial infections pose a serious risk for human health again, due to multi-resistant pathogens insensitive to antibiotic treatment. Some of the antibiotic resistance genes (ARGs) carried by these pathogens ... -
Cardiac functions of the cellular oxygen sensors prolyl-4-hydroxylase domain enzymes 2 and 3
(2012-07-24)Cardiovascular diseases are the major cause of death in the western world and produce furthermore the highest medical costs among all diseases. About 41% of all deaths in Germany in the year 2010 can be attributed to ... -
Characterization of Npl3 as a 5'- and 3'- quality control factor
(2023-09-11)Maturation of RNA polymerase II transcripts consists of 5’-capping, splicing, cleavage and 3’-polyadenylation. These processes can generate faulty transcripts that have to be retained in the nucleus to be degraded. An mRNA ... -
Comparative DNA‐Protein Interaction and Epithelial Tight Junctions Modulation Potential of Immunosuppressive Regime
(2016-01-28)Mycophenolic acid (MPA) is an important immunosuppressive drug (ISD) prescribed to prevent graft rejection in the organ transplanted patients. However, its use is sporadically linked to the leak flux diarrhea and other ... -
Diversity and Ecology of the Roseobacter Clade and other Marine Microbes as revealed by Metagenomic and Metatranscriptomic Approaches
(2015-05-29)Marine Bacteria and Archaea represent the major part of the total biodiversity on Earth. They are main drivers of biogeochemical cycles in marine environments and play an integral role in ecosystem structuring. Therefore, ... -
GlmY and GlmZ: a hierarchically acting cascade composed of two small RNAs
(2014-09-10)In Escherichia coli and other enterobacteria, the homologous small RNAs (sRNAs) GlmY and GlmZ act in a hierarchical manner to feedback control expression of key enzyme glucosamine-6-phosphate (GlcN6P) synthase GlmS. Enzyme ... -
Glycerolmetabolismus und Pathogenität von <i>Mycoplasma pneumoniae</i>
(2008-06-03)Mycoplasma pneumoniae, the causative agent of atypical pneumonia, is able to use glucose and fructose as well as glycerol as sole carbon source. Glycerol is taken up by facilitated diffusion ... -
Governing fungal polar cell extension: Analysis of Rho GTPase and NDR kinase signalling in Neurospora crassa
(2008-05-16)Polar morphogenesis is required for the function of elongated cell types like neuronal cells, pollen tubes and cells of filamentous fungi. The basal signalling components involved are highly conserved. Defects in polar ... -
Identification of interacting partners of mammalian target of rapamycin complex 1 (mTORC1) assembly in human lymphocytes
(2012-02-14)The mammalian target of rapamycin (mTOR) is an intracellular protein kinase that plays a key role in the control of cell growth, differentiation, cell survival, and cell proliferation. In ... -
Identifizierung schutzvermittelnder Antigene von Aspergillus fumigatus für eine Impfstoffentwicklung zur Verhütung invasiver Aspergillosen bei Leukämie-Patienten
(2015-01-23)A.fumigatus is the most common cause of invasive, usually fatal aspergillosis in severely immunocompromised patients. A natural resistance to the fungus is mediated by the innate immune system. Additionally, an acquired ... -
Impact of plant species, N fertilization and ecosystem engineers on the structure and function of soil microbial communities
(2014-02-26)Soil microbial communities are directly and indirectly influenced by a complex system of cross-interactions between different biotic and abiotic factors influencing each other, such as plant species and their respective ... -
Localization and Function of RNases in Bacillus subtilis
(2017-03-29)The ability to adapt to changing environmental conditions is essential for every organism to survive. In bacteria, this adaptation relies on the control of the mRNA synthesis, stability, and turnover, which allows the ...