Browsing Fakultät für Biologie und Psychologie (inkl. GAUSS) by Advisor "Doenecke, Detlef Prof. Dr."
Now showing items 1-12 of 12
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Nuclear import of histone fold motif containing heterodimers by importin 13
(2009-08-03)In this study, we have analyzed the nuclear import of two related histone fold pairs, CHRAC-15/17 and p12/CHRAC-17. The CHRAC-15/17 heterodimer is part of the chromatin accessibility complex ... -
Expressionsanalyse des humanen Histonsubtyps H1x
(2008-06-02)Nuclear eukaryotic DNA is organised as chromatin in conjunction with proteins. The basal structural organisation unit of chromatin is the nucleosome consisting of the nucleosome core particle, ... -
Nuclear transport of the DNA fragmentation factor via the classical importin α/β-pathway
(2007-11-02)One of the biochemical hallmarks of apoptosis is internucleosomal DNA fragmentation mediated by the endonuclease DNA fragmentation factor (DFF) 40. In proliferating cells DFF40 is expressed ... -
Patterns of post-translational histone modifications, chromatin condensation and DNA fragmentation during apoptosis
(2006-04-11)Cell shrinkage, formation of apoptotic bodies and chromatin fragmentation through cleavage of nucleosomal DNA into different fragment sizes catalysed by the DNase CAD (DFF40) are hallmarks ... -
Transcriptional Regulation of human Plasminogen Activator Inhibitor-1 Gene Expression by Insulin-like Growth Factor-1, Insulin and Upstream Stimulatory Factor-2
(2005-11-11)PAI-1 inhibits conversion of the proenzyme plasminogen to the active protease plasmin and modulates proteolytic processes associated with pathophysiological conditions such as prethrombotic ... -
Mechanisms underlying the nuclear transport of histones and histone-related proteins
(2005-11-11)The CCAAT-specific transcription factor NF-Y is a heterotrimeric complex composed of NF-YA, NF-YB, and NF-YC. Each subunit contains an evolutionarily conserved core region, comprising a ... -
Studies on the control and function of chromatin fragmentation during apoptosis
(2005-08-10)Apoptosis in eukaryotic cells is often accompanied by chromatin cleavage resulting in nucleosomal fragments. This cleavage is catalyzed by a DNase (named DFF40 or CAD) which is specifically ... -
The regulation of hypoxia-responsive gene expression by hydroxyl radicals and intracellular calcium
(2004-02-27)The heterogeneous oxygen distribution in tissues requires an oxygen-sensing system and a subsequent signaling pathway to allow the execution of adaptive responses. It has been proposed that ... -
Die Regulation der humanen H3-Histongene
(2003-11-14)The intention of the present thesis was to elucidate the transcriptional regulation of the 11 replication-dependent histone H3 genes and to investigate relationships to the in vivo ... -
Charakterisierung des Kerntransportsystems von Linker-Histonen
(2001-12-04)Histones are the major protein constituents of the eukaryotic chromatin. The lysine-rich H1 histones are located in the linker region of DNA between nucleosome cores. After their synthesis ... -
Faktoren des Kerntransports von Core-Histonproteinen: Strukturelle und funktionelle Analyse
(2001-07-18)Core histones are small basic proteins which form the nucleosomes in eukaryotic chromatin. In vitro nuclear import studies show that the four core histones H2A, H2B, H3 and H4 do not enter ...