Browsing Fakultät für Biologie und Psychologie (inkl. GAUSS) by Referee "Gradmann, Dietrich Prof. Dr."
Now showing items 1-20 of 24
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Molecular mechanisms governing germ line development in zebrafish and the role of this lineage in sexual differentiation
(2006-03-17)Primordial germ cells (PGCs) in zebrafish are specified early in the development by inheritance of a specific type of cytoplasm termed germ plasm. The asymmetrically distributed germ plasm ... -
Recognition of basic sorting motifs within synaptic membrane cargo proteins by the clathrin-adaptor complex AP-2
(2005-08-24)Communication in the central nervous system (CNS) occurs via chemical synapses, intercellular asymmetric junctions between an axon and the dendrite of a neighbouring neuron. Synapses comprised ... -
Studies on the control and function of chromatin fragmentation during apoptosis
(2005-08-10)Apoptosis in eukaryotic cells is often accompanied by chromatin cleavage resulting in nucleosomal fragments. This cleavage is catalyzed by a DNase (named DFF40 or CAD) which is specifically ... -
The Regulatory Role of Syntaxin 1 N-terminal Conformation in Vesicle Priming and Exocytosis
(2004-12-16)During vesicle priming at the central synapse, Syntaxin 1, together with SNAP25 and Synaptobrevin, assemble into the synaptic SNARE complex. The formation of SNARE complex is thought to ... -
Characterization of the 5-HT7(a) receptor: Specific receptor - G- protein interactions
(2004-08-31)Serotonin (5-hydroxytryptamine, or 5-HT) is very important neurotransmitter which regulates a variety of different physiological processes within the central Nervous System and at the ... -
Kartierung von umhüllungsrelevanten Aminosäureresten auf dem Hepatitis B Virus Kapsid
(2004-07-30)During morphogenesis of the hepatitits B virus (HBV) the cytosolic build nucleocapsid containing the viral genome interacts with transmembrane viral surface proteins to get enveloped into ... -
Role of transport systems in cortisol release from human adrenal cells
(2004-05-25)Adrenal steroid hormones (e.g., cortisol) play a pivotal role in the regulation and maintenance of metabolic homeostasis. The secretion of glucocorticoids from adrenocortical cells into ... -
Untersuchungen zu Struktur-Funktionsbeziehungen in der tRNA-ähnlichen Struktur des Rüben-Gelbmosaik-Virus
(2004-04-16)The Turnip-Yellow-Mosaic-Virus (TYMV) is a (+)-strand RNA-virus which infects plants of the Brassicaceae family. Its genome of 6318 nucleotides (nt) length contains a tRNA-like ... -
The regulation of hypoxia-responsive gene expression by hydroxyl radicals and intracellular calcium
(2004-02-27)The heterogeneous oxygen distribution in tissues requires an oxygen-sensing system and a subsequent signaling pathway to allow the execution of adaptive responses. It has been proposed that ... -
Post-translational generation of Cá-formylglycine in Prokaryotic Sulfatsases by Radical SAM-Proteins
(2004-02-16)Cá-formylglycine is the catalytic residue of sulfatases. FGly is generated by posttranslational modification of a cysteine (pro- and eukaryotes) or serine (prokaryotes) located in a conserved ... -
Zur Funktion des MPH1-Gens von Saccharomyces cerevisiae bei der rekombinativen Umgehung von replikationsarretierenden DNA-Schäden
(2004-02-11)MPH1 from Saccharomyces cerevisiae codes for a protein of the DEAH family. Genetic interaction studies of mph1 mutants, which show an mutator phenotype and are sensitive to a variety of ... -
Neuroligin: Charakterisierung eines neuronalen Transmembranproteins
(2004-02-06)Synapses are highly specialized contact sites where the communication between nerve cells takes place. Cell adhesion proteins are the key regulators of synaptogenesis and modulation. The ... -
Untersuchungen zur Rolle des <i>MPH1</i>-Gens aus <i>Saccharomyces cerevisiae</i> bei der Reinitiation der Replikation nach schadensinduzierten Arresten
(2003-12-10)For the error-free removal of DNA damages the damaged bases are usually removed by mechanisms like nucleotide or base excision repair (NER, BER), mismatch repair etc. and the resulting gap ... -
Exposition von Proteinen auf der Oberfläche von Escherichia coli Zellen: mechanistische Betrachtung und biotechnologische Anwendung
(2003-12-10)Methods of molecular evolution play an important role for the optimization of biomolecules with respect to function, stability, or interaction. A key aspect is the generation of protein ... -
Identifizierung der für die Agonisten-induzierte Phosphorylierung und Internalisierung relevanten Serine und Threonine in der C-terminalen Domäne des humanen Prostaglandin E2 Rezeptors, Subtyp EP4
(2003-08-18)The prostanoid receptors belong to the family of G protein-coupled receptors with seven transmembrane domains. Four different subtypes have been identified for prostaglandin E2 (PGE2). The ... -
Untersuchungen zu Nitrat-induzierbaren Proteinen der Plasmamembran von Chlorella saccharophila (Krüger) Nadson
(2002-12-05)The uptake of nitrate as the most important nitrogen source for higher and lower plants is mediated through constitutive and inducible nitrate-transport systems in the plasma membrane (PM). ... -
Gezielte Modifikation sowie Analyse der Bindungseigenschaften des Histidin Bindeproteins aus Escherichia coli und des GCN4 Leucinzippers aus Saccharomyces cerevisiae
(2002-11-27)The histidine-binding protein (HisJ) belongs to the super-family of soluble periplasmic receptor proteins in gram-negative bacteria like Escherichia coli. HisJ takes part in transloctation ... -
5HT 2 Rezeptor vermittelte Kontrolle des neonatalen medullären respiratorischen Netzwerks des Säugers
(2002-10-18)The serotonin 2B receptor (5HT 2B receptor) is an important regulator of embryonic development. Inactivation of the 5HT 2B gene leads to embryonic and early neonatal death in mice (Nebigil ... -
CHARACTERIZATION OF BACTERIAL LIPOPOLYSACCHARIDES (Pseudomonas syringae pv. tomato and Pseudomonas syringae pv. apii) AND PECTINS OF TOMATO AND CELERY PLANTS (Lycopersicon esculentum and Apium graveolens) REGARDING THEIR POSSIBLE ROLE IN HOST/PATHOGEN-INTERACTION
(2002-10-15)All plants face a formidable challenge of defending themselves against a large number of pathogens. The interactions between a pathogen and its host are governed by a number of factors. ... -
Characterisation of Vti1b and Vti1a proteins and generation of knock-out mice.
(2002-07-09)Genomic DNA for Vti1b and Vti1a was isolated and the chromosomal regions characterised. Using targeted gene disruption mouse mutants lacking Vti1b constitutively were generated. It was shown ...