Browsing Fakultät für Biologie und Psychologie (inkl. GAUSS) by Referee "Jahn, Reinhard Prof. Dr."
Now showing items 1-20 of 41
-
Elucidation of protein interactions in complex samples by protein-protein cross-linking of synaptosomes
(2019-08-23)Synapses are essential structures for inter-cellular communication in the central nervous system between neuronal cells. They form highly-specialized compartments that convert electrical to chemical signals, i.e. ... -
Analysis of the mechanisms of interaction of alpha-synuclein and membranes in cellular models of Parkinson´s Disease
(2018-12-04)Alpha-synuclein (aSyn) plays a crucial role in Parkinson’s disease (PD) and other synucleinopathies, since it misfolds and accumulates in typical proteinaceous inclusions known as Lewy bodies. The physiological function ... -
Modulating the aggregation of alpha-synuclein and prion protein with small molecules.
(2016-11-07)As living and health conditions improve in modern societies, the percentage of older people rises. A byproduct of this ageing is the marked increase of cases of cancer, cardiovascular, and neurodegenerative diseases. Many ... -
Transport Mechanisms of the Vesicular Glutamate Transporter 1
(2013-05-08)In neuronal signal transmission, vesicular neurotransmitter transporters play a key role in quantal size modification. They are filling synaptic vesicles (SVs) with neurotransmitter, fuelled by an electrochemical gradient ... -
Synaptic vesicle recycling <i>in Vivo</i>
(2012-03-12)The basic mechanism of neurotransmitter release at synapses is relatively well understood: upon arrival of an action potential, calcium influx into the nerve terminal triggers fusion of ... -
Regulation and communication between the NRD kinase COT1, the MAK2 MAP kinase and the Striatin complex in Neurospora crassa
(2012-02-22)Establishment and maintenance of cellular polarity are important and fundamental processes in eukaryotes, which have to be coordinated with cell division, differentiation, and cell growth. ... -
Biochemistry and physiological role of otoferlin
(2011-11-24)In humans deafness is caused by environmental but also by genetic factors. Mutations in the gene encoding otoferlin are one genetic cause of deafness, leading to DFNB9 an autosomal recessive ... -
Role of the different domains of PSD-95 in basal synaptic transmission
(2011-11-09)Learning and memory has been postulated to rely on changes in synaptic transmission strength. At excitatory synapses in the hippocampus CA1 region, synaptic strength is mainly regulated by ... -
Isolation and characterisation of synaptic vesicles from mouse brain
(2011-08-08)All eukaryotic cells exhibit a constant turnover of membrane components via trafficking of vesicles between subcellular compartments. A classical example of a dynamic membrane delimited ... -
Mechanisms of Multivesicular Body Biogenesis and Exosome Release
(2010-06-10)Exosomes are small vesicles with a diameter of approximately 50-100 nm that are secreted by a number of different cells and function in a multitude of intercellular signaling processes. ... -
On the chloride dependence of vesicular glutamate transport
(2010-06-10)Neurons release neurotransmitters in discrete amounts, the quanta. The transmitters are stored in small membrane-bound organelles, the synaptic vesicles, in the vicinity of the plasma ... -
Neue Einblicke in die SNARE-vermittelte Fusion: Detektion einzelner Proteoliposomen mit einem konfokalen Mikroskop
(2010-01-15)Neuronal exocytosis is of special interest amongst the multitude of membrane fusion processes taking place in different eukaryotic cells. Understanding the mechanism of fusion between the ... -
Überleben und Differenzierung TAT-Bcl-xL-transduzierter transplantierter neuraler Vorläuferzellen nach zerebraler Ischämie der Maus
(2010-01-06)Increased endogenous neurogenesis can be observed after cerebral ischemia in mice, but fails to significantly contribute to neural regeneration or integration. Therefore, the local application ... -
The timing of the final assembly of the SNARE complex in exocytosis
(2010-01-05)Transfer of information between individual neurons via exocytosis is mediated by fusion of secretory vesicles with the plasma membrane and requires assembly of the SNARE proteins Syntaxin-1, SNAP-25 and Synaptobrevin 2 ... -
Investigation of early endosomal sorting and budding
(2009-11-04)Early endosomes constitute a major sorting platform of eukaryotic cells. They receive endocytic carrier vesicles from the plasma membrane and trafficking vesicles from the Golgi complex and ... -
High-resolution characterization of structural changes involved in prion diseases and dialysis-related amyloidosis
(2009-10-16)Protein aggregation is the cause of several human diseases such as diabetes mellitus type 2, Parkinson s disease, Alzheimer s disease, Huntington s disease, spongiform encephalopathies, ... -
Eine funktionelle Charakterisierung der frühendosomalen SNARE-Proteine
(2009-06-19)Most intracellular transport processes occur via budding and fusion of vesicles, where fusion is dependent on SNARE proteins. Fusion is preceded by docking, the close contact of vesicles ... -
Free energy calculations of protein-ligand complexes with computational molecular dynamics
(2008-11-07)The accurate calculation of binding free energies for protein-ligand complexes is a field of extensive research. The accuracy in such free energy calculations from atomic-level molecular ... -
Biophysical Characterization of SNARE Complex Disassembly Catalyzed by NSF and alphaSNAP
(2008-09-17)SNAREs (SNAP receptors) are small membrane-bound proteins which are key mediators of intracellular membrane fusion. The actual fusion step is believed to occur through complex formation of ... -
Biophysikalische und thermodynamische Charakterisierung der neuronalen SNARE-Komplexbildung
(2008-07-16)Membrane fusion events are mediated by a set of conserved protein machinery, the SNARE proteins. SNARE proteins assemble into a very stable α-helical complex between two membranes. The ...