Browsing Fakultät für Biologie und Psychologie (inkl. GAUSS) by Referee "Nave, Klaus-Armin Prof. Dr."
Now showing items 1-17 of 17
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Myelin lipids are energy reserves in the nervous system
(2021-03-18)Neuronal functions critically depend on a continuous supply of glucose as prolonged hypoglycemia can lead to severe brain injury. It is surprising that except for astroglial glycogen the brain has no visible energy reserves. ... -
A neuronal PIP3-dependent program of oligodendrocyte precursor recruitment and myelination
(2017-01-26)Evolution of myelin has enabled rapid impulse propagation and development of complex brain circuitry. However, the in vivo mechanisms that trigger and orchestrate proliferation of oligodendrocyte precursor cells (OPCs), ... -
Analysis of peroxisomal turnover and myelin maintenance in mice with oligodendrocyte-specific MFP2-deficiency
(2016-11-02)Although caused by distinct genetic mutations, the peroxisomal disorders X-linked adrenoleukodystrophy (X-ALD), pseudoneonatal adrenoleukodystrophy (pseudo NALD), and neonatal adrenoleukodystrophy (NALD) share several ... -
Conditional activation of NRG1 signaling in the brain modulates cortical circuitry
(2015-12-01)Neuregulin (NRG) 1 contains an epidermal growth factor (EGF)-like signaling domain and serves as a ligand for receptor tyrosine kinases of the ErbB family. ErbB4, the main neuronal NRG1 receptor in the brain, is enriched ... -
The Role of 2',3'-Cyclic Nucleotide 3'-Phosphodiesterase (CNP) in the Peripheral Nervous System
(2015-10-19)In the peripheral nervous system (PNS) Schwann cells (SC) engulf, insulate and support motor and sensory axons. Nonmyelinating SC are associated with axons smaller than 1 µm in diameter, whereas myelinating SC form a compact ... -
Analyses of improved long term memory in SHARP1 and SHARP2 double knockout mice
(2015-09-15)The transition of recent experiences into stable and remote memory traces is an important task that mainly occurs during sleep. Sleep-associated consolidation of remote long-term memory is based on cortical networks that ... -
Der Einfluss von Neuregulin-1 auf Erkrankungen des peripheren Nervensystems
(2014-07-08)A duplication of the gene encoding the peripheral myelin protein 22kDa (PMP22) underlies the commonest inherited neuropathy, Charcot Marie Tooth disease 1A (CMT1A). Although demyelination is a characteristic disease feature, ... -
Genetic factors driving the functional specification of spinal motor neurons
(2012-11-06)Spinal motor neurons which innervate different types of muscle fibers play a pivotal role in controlling body postures and locomotion. Spinal motor neurons can be broadly classified into alpha- and gamma-motor neuron ... -
Characterization of the neuronal proteolipids M6A and M6B and the oligodendroglial tetraspans PLP and TSPAN2 in neural cell process formation
(2012-07-12)The tetraspan-transmembrane proteins of the M6-proteolipid proteolipid protein family are among the most abundant cell surface proteins in neurons. Their cellular function has remained largely speculative, also because ... -
Synaptic vesicle recycling <i>in Vivo</i>
(2012-03-12)The basic mechanism of neurotransmitter release at synapses is relatively well understood: upon arrival of an action potential, calcium influx into the nerve terminal triggers fusion of ... -
Untersuchungen der Funktion des Kleinhirns mit Hilfe von Mausmutanten
(2011-01-17)Analysis of cerebellar function using mouse mutans- NDRF regulates differentiation and axon development of cerebellar basket cells -The cerebellar cortex is essentially comprised of three ... -
Mechanisms of Multivesicular Body Biogenesis and Exosome Release
(2010-06-10)Exosomes are small vesicles with a diameter of approximately 50-100 nm that are secreted by a number of different cells and function in a multitude of intercellular signaling processes. ... -
Untersuchungen zur Funktion des basischen Helix-Loop-Helix (bHLH)-Transkriptionsfaktors ME2 bei Lern- und Gedächtnisprozessen in der Maus
(2009-08-20)ME2 (Tcf4) belongs to the basic helix-loop-helix (bHLH) transcription factor family, activates transcription of target genes by binding to so-called E-boxes elements and its mRNA expression ... -
Membranglykoprotein M6a: Expression und Regulation im Gehirn unter Stress
(2008-05-29)Glycoprotein M6a is a neuronally expressed transmembrane protein belonging to the myelin proteolipid protein (PLP) family. In vitro studies have identified M6a as a key modulator of neurite outgrowth and spine formation, ... -
Subcellular trafficking of proteolipid protein (PLP/DM20) and novel mechanisms of ER retention in Pelizaeus-Merzbacher disease
(2006-11-22)Missense mutations that predict the misfolding of membrane proteins have been associated with a number of neurogenetic diseases. However, it is not known how apparently minor changes in the ... -
Function of glial cells in the inhibitory synaptic transmission of the respiratory network
(2006-01-24)Glial cells of the respiratory network are necessary for the rhythm generation. They are believed to modulate the different neurotransmission pathways via their neurotransmitter transporters ... -
Trim2 mutant mice as a model for cerebellar ataxia
(2003-11-25)In the frame of a large scale gene trap (GT) mutation screening focused on identification of novel genes involved in CNS development and function, a mouse GT line was characterized showing ...