GZMB - Göttinger Zentrum für molekulare Biowissenschaften: Recent submissions
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Ein neu entdeckter Weg der Reparatur hydrolytisch geschädigter DNA-Cytosinreste, etabliert im thermophilen Archaeon Methanothermobacter thermautotrophicus ΔH
(2007-11-21)The DNA bases cytosine, adenine and guanine can be deaminated at the exocyclic aminogroups by spontaneous hydrolysis. Cytosine deamination leads to the RNA base uracil and is of particular mutagenic relevance, because ... -
Proteome-wide Identification of New Molecular Targets Affected by Methotrexate in Acute Promyelocytic Leukaemia Cell Line
(2007-06-11)Methotrexate (MTX) was first introduced as a cytotoxic agent that inhibits nucleotide biosynthesis in various cancer disorders. Accumulating evidences suggest that MTX inhibits the proliferation of malignant cells by ... -
Analyse der Funktion des Miz1 Gens bei Kardiomyopathie
(2012-03-27)The sarcomeric Z-disc is the main structure of the decentralized model of the muscle mechanotransduction. Proteins, which are anchored to the Z-disc are associated with cardiomyopathy. An example is the muscle LIM protein, ... -
The Role of the HECT-Type Ubiquitin Ligases WWP1 and WWP2 in Nerve Cell Development and Function
(2012-03-15)Posttranscriptional modification of proteins through the ubiquitin pathway has recently emerged as an essential regulatory mechanism controlling neuronal development and function. WW domain-containing protein-1 and -2 ... -
Metabolic and developmental functions of the transcription factor Gcn4p of Saccharomyces cerevisiae
(2011-10-17)The bakers’ yeast Saccharomyces cerevisiae executes two well established pathways, the ‘General Amino Acid Control’ (GAAC) and the ‘Unfolded Protein Response’ (UPR), which are in contrast to mammals not essential but ... -
Inducing neuroplasticity in the human motor system by transcranial magnetic stimulation: from pathophysiology to a therapeutic option in movement disorders
(2010-05-17)Transcranial magnetic stimulation (TMS) has become a well established method to non-invasively assess corticospinal excitability in human subjects. In addition repetitive transcranial magnetic stimulation (rTMS) is capable ... -
Untersuchungen zur Funktion der Gene MPH1 und MMS2 aus Saccharomyces cerevisiae bei der fehlerfreien Umgehung von replikationsarretierenden DNA-Schäden
(2010-02-25)in vivo error free bypass of replication blocking lesions is done by at least two distinct processes: homologous recombination via sister chromatid interaction (SCI) and post replicative repair (PRR). Additionally PRR is ... -
Participation of Eag1 in tumor relevant pathways
(2010-01-12)Ether--go-go-1 (Eag1) is a CNS-localized voltage-gated potassium channel that is found ectopically expressed in a majority of extra-cranial solid tu- mors. While evidence linking Eag1 to tumor biology has been well ... -
Expression of SLC transporters in Chronic Lymphocytic Leukaemia cells and their interaction with cytostatics
(2009-11-18)Chronic Lymphocytic Leukaemia, CLL, is one of the most common forms of leukaemia in the elderly. The treatment regimen determines the outcome of patients with CLL and the efficiency of this treatment is modulated by the ... -
Gene prediction in metagenomic sequencing reads
(2009-11-13)Gene prediction is an essential step in the annotation of metagenomic sequencing reads. Since most metagenomic reads cannot be assembled into long contigs, specialized gene prediction tools are required for the analysis ... -
Functional Characterisation of Syndecan, a heparan sulpahte proteoglycan, in Slit/Robo signalling
(2008-04-25)Syndecan (Sdc) is a type I transmembrane protein characterized by the presence of linear sugar chains called heparan sulphate glycosaminoglycans (HSGAGs) linked to its extracellular domain. Sdc was shown to be critical for ... -
Identifizierung und Charakterisierung extrazellulärer Proteine unter dem Einfluss von Verticillium longisporum in Arabidopsis thaliana und Raps (<i>Brassica napus</i>)
(2008-03-04)Verticillium species are soil-borne, xylem-colonizing fungi with worldwide distribution in temperate and subtropical regions. They cause vascular disease in many agriculturally important crops. Verticillium longisporum ... -
Die Funktion der inflammatorischen CCR2+ Monozyten bei der postnatalen Mikrogliaentwicklung und bakteriellen Meningitis
(2008-02-12)The central nervous system (CNS) differs from other organs in its privileged status in relation to the immune system. To ensure a specific and stable neuronal environment, the blood-brain barrier separates it from the ... -
Transcriptional control in the context of primary neurogenesis
(2006-09-18)The Myc/Max/Mad network of bHLH-Zip transcription factors plays an essential role in a variety of cellular processes including proliferation, differentiation and apoptosis. Mxi1, a Mad family member, was previously ... -
The rhizosphere effects of <i>Fagus sylvatica</i> L. and <i>Fraxinus excelsior</i> L. saplings on greenhouse gas fluxes between soil and atmosphere
(2012-12-07)Tree species influence the soil through stemflow and throughfall water, leaf litter and the root system. Little is known about the effects of tree roots on the C and N dynamics of the soil and the gas exchange with ...
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Functional Characterization of Hereditary Spastic Paraplegia Proteins Spastin and ZFYVE27
(2010-04-20)Hereditary spastic paraplegias (HSP) are a heterogeneous group of genetic disorders characterized by progressive spasticity in the lower limbs caused primarily due to dysfunction of ... -
Investigation of Protein Structure and Dynamics
(2009-07-22)This thesis addresses three aspects of protein function:Part I describes the structural investigation of a calmodulin-peptide complex by NMR spectroscopy. The intracellular calcium sensor ... -
Mikroautophagischer Abbau von Teilen der Kernhülle und Untersuchungen zum Transport und der Aktivität von Atg15p in der Hefe Saccharomyces <i>cerevisiae</i>
(2008-08-12)Autophagy is a ubiquitous process, occurring in all eukaryotic cells. Microautophagy sequesters cytoplasm or organelles by invagination or septation of the vacuolar membrane. In Saccharomyces ...