Dokumente Fakultät für Chemie (inkl. GAUSS) nach Gutachter "Diederichsen, Ulf Prof. Dr."
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Der Einfluß von chemischer Konstitution, Symmetrie und molekularer Umgebung auf die intramolekulare Schwingungsrelaxation aromatischer Moleküle
(2006-03-24)This thesis focuses on elucidating mechanisms of intramolecular vibrational energy redistribution (IVR). It constitutes a comparative study on structurally closely related aromatic molecules ... -
Elektrophysiologische Charakterisierung des mitochondrialen Porins VDAC1 und des antimikrobiellen Peptids Dermcidin in lösungsmittelfreien Modellmembranen
(2013-07-04)Solvent free lipid bilayers were used for the electrophysiological characterization of the most abundant protein of the outer mitochondrial membrane, the isoform 1 of the voltage dependent anion channel (VDAC1), and the ... -
Elucidation of Unconventional Bonding in Lithium Organic Compounds
(2009-08-07)The major goals of this thesis were to synthesise and crystallise novel unsubstituted picolyl metal adducts for structural analyses. Their investigation as well as other lithium organic ... -
Entwicklung katalytischer Kreuzkupplungs- und Hydroaminierungsreaktionen
(2008-11-13)In recent years great efforts have been taken for the development of highly active catalysts in the field of hydroamination- and cross-coupling-reactions. However, there is still a lack of ... -
Entwicklung von Lanthanoid-Tags für die biomolekulare NMR-Spektroskopie
(2011-05-02)Paramagnetically induced effects such as pseudocontact shifts (PCSs) and residual dipolar couplings (RDCs) are valuable parameters for biomolecular NMR spectroscopy. They contain angular ... -
Fatty acid oxidizing enzymes in Lobosphaera incisa
(2018-04-23)Green microalgae are a model in biotechnology because of their capacity to accumulate neutral lipids, as part of a general lipid remodeling mechanism under stress. The species L. incisa is of special interest for its unique ... -
Fluorescence based studies on neuronal processes
(2015-07-22)Synaptotagmin-1 is a calcium dependent trigger of the SNARE-fusion machinery that ultimately upon stimulation executes signal transmission between neurons. However, the actual mechanistic function and the role of ... -
Fluorescent Dyes and Quenchers with Rigid Linkers
(2017-03-16)Electronic energy transfer (EET) between chromophores is of fundamental importance for many natural processes and technical applications. However, common models fall short in fully describing the process, especially in ... -
Hochohmige porenüberspannende Lipidmembranen: Elektrochemische Untersuchungen zur Aktivität von Gramicidin und Bacteriorhodpsin
(2009-07-14)To study transmembrane proteins they need to be integrated in a lipid environment to preserve their functionality. For this purpose, model membranes have been developed which allow the ... -
Hybrids of SNARE Transmembrane Domains and Artificial Recognition Motifs as Membrane Fusion Inducing Model Peptides
(2018-03-13)Protein mediated fusion of membranes is a crucial biological process. For instance, SNARE (soluble N-ethylmaleimide-sensitive factor (NSF) attachment protein receptor) proteins are involved in neuronal exocytosis. However, ... -
Indole Alkaloids as Potential Leads in Drug Discovery and Further Secondary Metabolites from Terrestrial and Marine Bacteria
(2012-01-04)Microorganisms take a large influence on ecological and symbiotic interactions in long-term relationships that are moderated by secondary metabolites with often-unique structure and biological ... -
Influence of point mutations on the electrophysiological properties of a bacterial porin and its interaction with a β-lactam antibiotic
(2018-09-19)The high rate of complications and mortality in hospitals due to multidrug resistances (MDR) of gram-negative bacteria demonstrates the urgency to understand the underlying mecha-nisms. One common cause of MDR are mutations ... -
Intramolekulare Titan-vermittelte Aminocyclopropanierung als Zugang zu N-Benzyl-4-alkyl-2-azabicyclo[3.1.0]hexanen - Synthese von tri- und tetrasubstituierten Alkenen durch Palladium-katalysierte Kreuzkupplung von Alkin-Titan-Komplexen
(2004-11-02)Alkene- and alkadiene-substituted formamides were intramolecularly amino-cyclopropanated. Furthermore, titanium-complexes of unsaturated compounds were cross-coupled with severa bromobenzenes via ... -
Investigation of Peptidic Templates for Bioorthogonal Ligations
(2021-08-16)One of the biggest challenges for biochemical researchers in the postgenomic era remains the elucidation of structure-activity relationships in proteins. While many proteins can be routinely produced by recombinant protein ... -
Investigation of the Linker Region of Coiled Coil SNARE-Analoga and Membrane Composition on Vesicle Fusion
(2021-03-09)SNARE (soluble N-ethylmaleimide-sensitive-factor attachment receptor) proteins play a major role in membrane fusion processes in many organisms. As these proteins form a sophisticated tetrameric coiled coil complex, many ... -
Iron- and Ruthenium-Catalyzed Site-Selective C–C Forming Direct C–H Functionalizations
(2015-04-09)During the last decades, C‒C bond forming reactions have been established as one of the most important tools for modern organic synthesis for the functionalization of otherwise difficult to activate compounds. The inexpensive ... -
Lateral Organization and Thermodynamics of Coiled-coil Lipopeptides - Implications for Docking and Fusion Efficiency
(2013-01-24)Specific cellular membrane interaction is a crucial point in nature as it facilitates key processes like cell-cell communication or membrane fusion. The latter one is highly controlled frequently mediated by the superfamily ... -
Liganden mit N/S-Donorsets in der Münzmetallchemie: Modellkomplexe für Methanobactin und multinukleare, lumineszierende Pyrazolat-Komplexe
(2013-03-12)The synthesis and characterization of pyrazolate and oxazolone ligands with attached thioether functions is described. These ligands were used either to synthesize copper(I) complexes as model complex for the methanobactin ... -
Long-range EPR distance measurements with semi-rigid spin labels at Q-band frequencies
(2017-03-02)Elucidating the structure of biomolecules is essential to understand their function. Pulsed electron double resonance (PELDOR) in conjunction with site-directed spin labelling has become a well-established experiment for ... -
Mechanical properties of pore-spanning membranes prepared from giant vesicles
(2011-05-25)Research interest in the mechanical properties of membranes arises from the multitude of morphological and physiological functions they govern. However, the complexity of native membranes ...