Dokumente Fakultät für Chemie (inkl. GAUSS) nach Gutachter "Diederichsen, Ulf Prof. Dr."
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Metagenom-Technologie zur Wirkstoffsuche sowie Untersuchungen der Iromycine aus Streptomyces sp.
(2008-01-24)The present thesis deals with the screening for bioactive natural products and detailed studies of the group of iromycin polyketides to address the questions of biosynthesis, biological ... -
Modification of transmembrane peptides to probe SNARE-induced membrane fusion and cross-presentation of membrane-buried epitopes
(2021-02-19)Membrane proteins play an important role in cellular function as receptors, transporters, anchors, and catalysts. Despite constituting 20-30% of the human proteome only 3 % of all characterized proteins are membrane proteins ... -
Monomeric Organo Aluminum and Gallium Monohydroxides as Precursor for Homo and Hetero Bimetallic Oxides: Synthetic, Reactivity and Structural Investigations Including Gold(I) N heterocyclic Carbene Complexes
(2006-11-08)The first part of my thesis deals with the syntheses of β-diketiminate Group 13 methyl chlorides of the general formula LM(Me)Cl (M = Al, Ga, In) [L = HC{(CMe)N(2,6-iPr2C6H3)}2]. ... -
Neue Übergangsmetall-vermittelte Reaktionen zum effizienten Aufbau cyclopropanhaltiger Oligocyclen
(2004-10-20)The objective of this thesis is the development of new transition metal-mediated reactions for the construction of cyclopropanated oligocycles. In the first part of the thesis, the ... -
New Pyrazole- and Triazine-Based Ligands as Scaffolds for Oligonuclear Complexes: From Multiredox Stability to Heteronuclear Single Molecule Magnets
(2010-03-15)My doctoral work is based on the multistep synthesis of a new family of triazine- and pyrazolate-based compartmental ligands, and their multi-nuclear transition metal complexes, which are ... -
NMR investigations of 15.5K associated protein-RNA complexes
(2008-01-28)The spliceosome, consisting of different snRNPs and numerous non-U snRNP factors, catalyzes the splicing reaction. To activate the spliceosome and enable the first step of splicing to begin, ... -
Novel Syntheses of Nitrogen Heterocycles from Isocyanides
(2010-02-22)The direct copper(I)-catalyzed synthesis of 2,3,4-trisubstituted and 3,4-disubstituted pyrroles from substituted methyl isocyanides and acceptor-substituted acetylenes as well as the newly ... -
Oligomer modulator anle138b and related compounds in neurodegeneration and beyond
(2020-12-10)Neurodegenerative diseases including Alzheimer’s disease, Parkinson’s disease, Creutzfeldt-Jakob disease are characterized by a progressive deterioration of brain function as a result of a gradual loss of nerve cells. Due ... -
Organisation and Recognition of Artificial Transmembrane Peptides
(2016-11-15)A various number of cellular key functions such as signalling and transport are mediated by membrane proteins, which are either adhesively bound to the membrane surface or exhibit transmembrane domains. Many transmembrane ... -
Palladium(II)-katalysierte Domino-Reaktionen zur enantioselektiven Synthese von Confluentin, Daurichromen- und Rhododaurichromansäure Untersuchungen zur Synthese von Aglaroxin A
(2011-04-28)This thesis is about Palladium(II) catalysed Domino Reactions for the enantioselective Synthesis of Confluentin, Daurichromenic and Rhododaurichromanic acid. These substances were isolated ... -
Palladium-Catalyzed Oligocyclizations of Some 2-Bromotetradec-1-ene-7,13-diynes Under Heck Reaction Conditions
(2003-12-16)Synthesis of different substituted 2-bromotetradec-1-ene-7,13-diyne precursors can be easily achieved by using 1,7-octadiyne. The cyclization outcome of these precursors depends on the type ... -
Paramagnetisch markierte Oligonukleotide
(2009-09-11)Two methods to obtain paramagnetically tagged oligonucleotides are described. To get a biomolecule with a paramagnetic center a radical or metal moiety has to be introduced. This was done ... -
Post-Synthetic DNA-Functionalization Based on DNA-Templated Dynamic Chemistry
(2015-06-26)With the growing field of DNA technology there is an increasing demand for new modifications of DNA, which improve its versatility and promote the DNA as a fundamental scaffold for a wide field of applications like catalysis, ... -
Prebiotic Synthesis of Inorganic Pyrophosphate (PPi) Driven by a Geochemical Redox Reaction
(2021-10-21)In all extant organisms adenosine triphosphate (ATP) is the energy carrier and transmitter of free energy from exergonic to endergonic processes. Since ATP is a complex molecule, it was unlikely available on prebiotic ... -
Quantitative analysis of protein-protein interactions governing TASK-1/TASK-3 intracellular transport
(2016-07-27)The transport of the K+-channels TASK-1 and TASK-3 to the cell surface is regulated by protein-protein interactions with either the COPI vesicle coat, or members of the phosphoadaptor protein family 14-3-3. Interactions ... -
Ruthenium(II) biscarboxylate-Catalyzed C(sp2)-H and C(sp3)-H Functionalizations by Chelation Assistance
(2016-12-06)Functionalizations of C(sp2)-H and C(sp3)-H bond were achieved by Ruthenium(II) biscarboxylate complexes in an atom- and step-economic fashion. -
Ruthenium-Catalyzed Synthesis of Biaryls through C–H Bond Functionalizations
(2013-11-15)The main focus of this work was the development of new methodologies for the efficient and step-economical synthesis of biaryls cores by direct arylation through direct C–H bond cleavage. In this aim, the first ruthenium-catalyzed ... -
Rutheniumkatalysierte Addition von nicht aktivierten C(sp²)–H- und C(sp³)–H-Bindungen an Alkene
(2013-04-30)Novel site-selective carboxylate assisted ruthenium-catalyzed hydroarylations of unactivated alkenes, bearing valuable functional groups, with various (hetero)arenes has been accomplished. And a unprecedented ruthenium ... -
S-Substituted Dibenzothiophenium Triflates: Synthesis, Structure and Reactivity
(2021-04-23)The content of this thesis focused on the general syntheses and applications S-substituted alkynyl-, alkenyl- and aryldibenzothiophenium triflates. Addition reactions have been performed from S-alkynyldibenzothiophenium ... -
Self-Organization of β-Peptide Nucleic Acid Helices for Membrane Scaffolding
(2019-08-06)In a vast number of cellular processes interactions between membranes and proteins are essential, resulting in the lipid bilayer being interspersed immensely with proteins. Apart from catalytic or signaling functions, a ...