Dokumente Fakultät für Chemie (inkl. GAUSS) nach Gutachter "Laatsch, Hartmut Prof. Dr."
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Aqabamycins, Rare Nitro Maleimides and other Novel Metabolites from Microorganisms; Generation and Application of an HPLC-UV-ESI MS/MS Database
(2009-06-04)The battle to improve the quality of life by finding cures against diseases and to extend the life expectancy of mankind is still one of the priorities in natural products chemistry. Al-though ... -
Asymmetrische Allylierung von prochiralen Ketonen und deren Anwendung in der Synthese von Pinnatolid und Furopinnatin
(2012-07-30)Allylation reactions are one of the most frequently employed C–C bond formation reactions which are often used in the synthesis of natural compounds. There are many procedures known for asymmetric allylation of aldehydes ... -
Aufbau von Bausteinen zur Synthese von Spinosynanaloga
(2012-05-22)The Spinosyns A and D are the main metabolites of the Streptomyces species Saccharopolyspora spinosa. They show a high activity as well as a high selectivity against a huge number of insects that cause extensive damage ... -
Bandamycin as New Antifungal Agent and further Secondary Metabolites from Terrestrial and Marine Microorganisms
(2012-05-03)In this study, eight terrestrial and two marine bacteria, and four endophytic fungi have been investigated chemically and pharmacologically, out of which a total of fourty-eight secondary metabolites were isolated. ... -
Chemisches Screening von ausgewählten Actinomyceten sowie Strukturaufklärung von Sekundärmetaboliten aus Micromonospora sp. und Pflanzen
(2004-04-27)The core of this thesis is the study of microorganisms and plants of different sources with regard to their production of secondary metabolites.The first part deals with 35 actinomycete ... -
Crystal Structures of a Bacterial Isocitrate Dehydrogenase and the Human Sulfamidase
(2015-01-09)In an X-ray crystallographic experiment, intensities and directions of X-rays scattered by electrons in a crystal are measured. However, the relative phase information in the interference pattern is lost. If we knew the ... -
Crystallographic studies on DNA in complex with antibiotics and effects of anisotropic scaling on structure solution
(2008-12-01)This work investigates the structure of complexes between DNA and antibiotics discussing the crystal structures of d(AACCGGTT)-trioxacarcin, d(CGTACG)-trioxacarcin and d(ACGTACGT)-echinomycin. ... -
Design und Synthese neuer flüssigkristalliner Substanzen mit zentraler Bicyclo[3.1.0]hexaneinheit
(2003-07-10)Starting from the first observations of the phenomenon of liquid crystallinity by Reinitzer in 1888 and by Lehmann in 1889, the design and preparation of molecules possessing liquid crystalline ... -
Development of Viable Synthetic Approaches to Highly Functionalized Small Ring Systems - Synthesis of Novel Cyclopropylacrylates as Monomers for Low-Shrinkage Polymer-Composites
(2005-07-13)Twenty-eight new alkyl 2-cyclopropylacrylates with various substitution patterns were synthesized from readily available precursors applying appropriately modified variants of standard transformations or newly developed ... -
Hoch cytotoxisches Kettapetin, Bhimamycine mit ungewöhnlichen Chromophoren und weitere neue Sekundärstoffe aus terrestrischen und marinen Bakterien
(2006-02-27)Nature is a source of medicinal agents since thousands of years, and an impressive number of modern drugs has been isolated from natural habitats, many based on their use firstly in traditional ... -
Die Iromycine und das Collinolacton: Synthese mikrobieller Naturstoffe aus Streptomyces sp.
(2007-10-19)In this work the total synthesis of two natural products - iromycins A and collinolacton was studied. The total synthesis of iromycin A, a microbial metabolite combining a novel structure ... -
Isolation, Purification and Structure Elucidation of New Secondary Metabolites from Terrestrial, Marine, and Ruminal Microorganisms
(2012-12-19)The search for microorganisms useful in agriculture, agroalimentary and pharmaceu-tical industries requires the exploration also of ecological niches. Thus, within this background, the rumen (one of the four stomach parts ... -
Isolierung und Strukturaufklärung neuer Naturstoffe aus Bakterien und endophytischen Pilzen durch chemisches Screening
(2005-09-26)The present work deals with the isolation and structure elucidation of new secondary metabolites from bacteria and endophytic fungi, found by chemical screening. The antimicrobial and ... -
Metabolite aus marinen und terrestrischen Bakterien und Pilzen sowie Untersuchungen von Invertebraten der Tiefsee
(2003-07-25)In this work 24 bacterial and eight fungi strains were submitted to the chemical screening for their ability to produce secondary metabolites. 17 of the bacterial and all fungi strains were ... -
Palladium(II)-katalysierte Domino-Reaktionen zur enantioselektiven Synthese von Confluentin, Daurichromen- und Rhododaurichromansäure Untersuchungen zur Synthese von Aglaroxin A
(2011-04-28)This thesis is about Palladium(II) catalysed Domino Reactions for the enantioselective Synthesis of Confluentin, Daurichromenic and Rhododaurichromanic acid. These substances were isolated ... -
Potentiell photochrome brückenkopfsubstituierte Furo[2,3-d]furane
(2002-04-08)Within the scope of this thesis a photochromic system consisting of furo[2,3-d]furans and bis-quinonemethides was investigated. In the literature the known compounds of this system are ... -
ps-UV-Pump REMPI-Probe Spektroskopie an <i>trans</i>-Stilben van-der-Waals-Clustern im Überschalldüsenstrahl
(2001-07-18)The reaction rate of the unimolecular trans-cis-isomerization of trans-stilbene in the first excited state (S1) is influenced by cluster formation. Photoinduced reactions of ... -
Sekundärstoffe aus endophytischen Pilzen mariner Habitate und Abbaureaktionen an Simocyclinon D8
(2008-01-09)This thesis deals with the isolation, characterization und chemical derivatization of natural products. Most of the described metabolites show a high potential biological activity which is ... -
Struktur und Biosynthese von Spirodionsäure und Kirromycin aus Streptomyces sp.
(2009-04-09)The first project is about the investigation of the biosynthesis of the novel microbial metabolite spirodionic acid and its absolute stereoconfiguration. Within the scope of these biosynthetic ... -
Strukturaufklärung der Phenalinolactone und Beiträge zur Biosynthese der Hexacyclinsäure
(2004-04-27)This work concentrated on biosynthetic studies as well as the isolation and structure elucidation of natural substances of streptomycetes. In line with a cooperation with the workgroup of ...