Browsing Fakultät für Chemie (inkl. GAUSS) by Referee "Steinem, Claudia Prof. Dr."
Now showing items 1-20 of 53
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Influence of ezrin's actin binding properties on the formation of minimal actin cortices
(2024-02-16)The cytoskeleton is a pivotal structure within cells, crucial for their motion and life-indispensable processes. The actin cortex is a dense actin network that is part of the cytoskeleton and linked to the plasmamembrane. ... -
Investigating Synthetic Approaches of the Neuroregulator α-Synuclein
(2024-01-04)Neuronal disorders such as Parkinson's disease, multiple system atrophy and dementia with Lewy bodies affect millions of patients worldwide. They belong to a group of neurodegenerative diseases called synucleinopathies, ... -
Relevance of formins in the wound healing and actomysin cortex dynamics of cardiac fibroblasts
(2023-06-12)Upon myocardial infarction, the natural healing response triggers the fibroblast-to-myofibroblast transition (FMT). Through this process, fibroblasts acquire a myofibroblast phenotype by which they present increased mobility, ... -
Structure and Mechanics of Membrane-bound Vimentin Filaments and Networks under Strain
(2022-12-16)The shape and mechanical properties of eukaryotic cells are determined by the cytoskeleton, composed of actin filaments, microtubules and intermediate filaments (IFs). Among these, IFs are considered to be the main ... -
Templat-vermittelte Synthese zyklischer Peptide an programmierten Coiled-Coil-Gerüsten
(2022-12-12)In recent years, macrocyclic peptides have experienced a renaissance in research. Due to their restricted conformation, they have a high substrate specificity and, relative to their size, a large surface area. This is ... -
Untersuchungen zur Aggregation des ALS-relevanten TDP-43(307-347)
(2022-12-12)Amyotrophic lateral sclerosis (ALS) is a fatal, multicausal, neurodegenerative disease for which there is so far no cure. Abnormal cytoplasmic aggregates of TDP-43, a multifunctional RNA-binding protein, are a pathological ... -
Probing SNARE-Induced Membrane Fusion Using Peptidic Model Fusogens
(2022-11-10)In this thesis, SNARE analogues with artificial recognition units made of either coiled-coil sequences or peptide nucleic acid (PNA) oligomers were synthesized. By applying FRET-based liposome fusion assays, the fusogenic ... -
Towards a total synthesis of bazzanin K
(2022-05-31)Bazzanin K is a natural product from the group of macrocyclic bis-bibenzyls which was isolated from the liverwort bazzania trilobata. This work is dedicated towards the development of a synthetic strategy with bazzanin K ... -
Metal-induced aggregation of ß-peptides on membrane surfaces
(2022-04-05)According to the liquid mosaic model of Singer and Nicolson, the cell membrane defines the boundaries of a cell to the inside and outside and describes a twodimensional lipid bilayer. Integrated into this lipid bilayer ... -
Reconstitution of Connexin-43 in Artificial Membranes
(2022-04-01)Synthetic biology aims to engineer complex biological functions in an artificial way. A variety of molecular tools and techniques allow mimicking of processes of living systems in a synthetic way. In that context, the ... -
Aufbau einer Silicanin-1-haltigen Modellmembran des Silicafällungsvesikels aus Thalassiosira pseudonana
(2021-12-23)Silica polycondensation occurring in diatom organelles called silica deposition vesicles (SDVs) leads to valve and girdle band formation to complete the biosilica cell wall after cell division. This biosilica shows ... -
Synthesis of β-Peptides for the Organization as Helix Bundles in Lipid Membranes
(2021-12-03)In this work, syntheses and analyses of transmembrane β-peptides were performed. On the one hand, a novel β-peptidic molecular ruler was designed which enables the measurement of near-membrane ion concentrations. On the ... -
Interaction of antimicrobial compounds with lipid bilayers in established and novel membrane model systems
(2021-05-06)Investigating the interaction between antimicrobial compounds and membrane model systems in the form of artificial lipid bilayers provides important insights into their mode of action. The interaction of lipid side chains ... -
Synthesis of Modified Biomolecules to Investigate Neuronal Processes
(2021-04-30)Action potentials are an essential process for signal transmission in excitable cells. At chemical synapses, the action potential triggers the release of neurotransmitters from synaptic vesicles to transmit the signal to ... -
Investigation of the Linker Region of Coiled Coil SNARE-Analoga and Membrane Composition on Vesicle Fusion
(2021-03-09)SNARE (soluble N-ethylmaleimide-sensitive-factor attachment receptor) proteins play a major role in membrane fusion processes in many organisms. As these proteins form a sophisticated tetrameric coiled coil complex, many ... -
Entwicklung und Evaluation von Konzepten und Formaten zum Wissenstransfer von der Forschung in die Schule und Öffentlichkeit - Am Beispiel des SFB 803
(2020-10-27)In scientific research, involvement of society within the context of science outreach pro-jects gains increasing importance. While numerous offers which serve to promote gen-eral interest in the natural sciences exist, so ... -
Phase separation of biomimetic membranes:
(2019-12-11)The bacterium enterohemorrhagic Escherichia coli (EHEC) is one of the main causes of food borne illness. The toxin of this bacteria is shiga toxin (STx) which inhibits the protein biosynthesis of cells. Approaching the ... -
Synthesis of rare nucleobases and artificial nucleotides for investigation of catalytic enzyme activity
(2019-10-25)Enzymes are involved in replication, transcription and translation of DNA, as well as the synthesis of nucleobases. The roles and mechanisms for many of these enzymes stay broadly unknown until today. The herein presented ... -
Self-Organization of β-Peptide Nucleic Acid Helices for Membrane Scaffolding
(2019-08-06)In a vast number of cellular processes interactions between membranes and proteins are essential, resulting in the lipid bilayer being interspersed immensely with proteins. Apart from catalytic or signaling functions, a ... -
Synthesis, characterisation and sensor-functionalisation of transmembrane β-peptides
(2019-07-31)Membrane proteins represent an important class of proteins as they are encoded in up to 30 % of the open reading frame. More than 50 % of currently available drugs target membrane proteins, emphasising the importance of ...