Browsing Naturwissenschaften, Mathematik und Informatik by Referee "Alcarazo, Manuel Prof. Dr."
Now showing items 1-20 of 58
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β-Hydrogen Eliminations from Organoaluminates and -Cuprates in the Gas Phase
(2025-12-10)The β-hydride elimination is a fundamental process in many organometallic reaction mechanisms and decomposition pathways. This thesis investigates the β-hydride elimination of alkyl organoaluminates and alkyl organocuprates ... -
Bis(amidophenolate)-supported Pnictogen Complexes: Redox Activity, Cooperativity and Electromerism
(2025-11-26)This thesis describes the synthesis, characterization and reactivity of pnictogen compounds derived from the tetradentate, redox-active bis(amidophenolate) ligand, N,N′-bis(3,5-di-tert-butyl-2-phenoxy)-1,2-phenylenediamide. ... -
Predictive in silico models for competing reaction mechanisms
(2025-09-08)Reactivity is one of the most fundamental concepts in chemistry, determining if a chemical transformation is taking place, its elementary steps and how fast it is. Due to the exponential dependence of the rate constant on ... -
Exploring Transient Dialumene and Diazido-Dialane: Low Oxidation State Aluminium Chemistry based on a Hybrid Ligand
(2025-06-12)This thesis focuses on the exploration and development of the hybrid NacNac-Box-akin ligand, DippNac-Indole (DNI), and its application in stabilizing low oxidation state aluminium complexes. The study is structured to ... -
Preorganization within a pyrazolato-bridged bis-β-diketiminato dinickel frame as a key tool to access terminal sulfides and synergistically stabilized intermediates for acetyl-CoA synthase mimetic thioester formation
(2025-05-21)Bimetallic complexes are frequently employed in natural enzymes and in applications such as imaging, targeting, and catalysis, in order to exploit the synergy between two metal centers or to combine different functionali ... -
Synthesis of Pyrrolo[1,2-c]pyrimidine-1-ylidenes: Coordination Chemistry and Application as Ancillary Ligands for Metal Catalysis
(2025-03-20)N-heterocyclic carbenes (NHCs) represent an important class of ancillary ligands for transition metal catalysis due to their strong binding character and generally simple syntheses procedures. One important feature of these ... -
Cooperative Activation of Small Molecules on Preorganized Dinuclear Cobalt Complexes
(2025-03-14)The coordination chemistry of late-transition-metal dinitrogen complexes remains a topic of considerable interest. In this study, a pyrazolate-based dinucleating nacnac ligand was employed to construct a series of bimetallic ... -
Investigation of Framework-forming Aggregation of Peptide Helices on Membrane Surfaces
(2025-02-14)This study presents the development and investigation of peptide-based systems designed to induce controlled aggregation on membrane surfaces, potentially facilitating cell signaling by promoting lipid raft formation. The ... -
On the chemistry of sulfur: Development of NOS bridge model systems and Stereoretentive 2,3-bis(trifluoromethyl)cyclopropanation of heteroarenes via sulfonium salts
(2025-02-05)This thesis presents research conducted across two distinct projects in sulfur chemistry. The first project focused on the synthesis of model systems based on biphenyl, xanthene, and triazamacrocyclic scaffolds to investigate ... -
Enantioselective Synthesis and Postsynthetic Functionalization of Thiahelicenes and their Oxa-analogues
(2025-01-30)Based on the Alcarazo group’s experience in enantioselective Au(I)-catalyzed synthesis of (hetero)helicenes employing alkyne hydroaryration reactions, the gold precatalyst 188c, combining a chiral BINOL-derived backbone ... -
3d-Metall-Käfig-Komplexe als Modelle für aktive Zentren von nicht-Häm Proteinen
(2024-10-22)This thesis presents a broad study on a new ligand system, specially designed for the mimicry of the quasi-chelating coordination by amino acid side chain residues in enzymatic pockets. The ligand system is based on an ... -
Enabling Novel Fluoroalkylation via Sulfonium Salt Transfer Reagents
(2024-08-26)Over the past four decades, sulfonium salt-based transfer reagents have evolved into widely recognized tools for fluoroalkylation in the synthetic chemistry community. These reagents have enabled the incorporation of various ... -
Synthesis of Novel Sulfur(VI) Reagents and the Regioselective Functionalization of Helicenes by Hypervalent Reagents
(2024-06-28)The synthesis of novel sulfur(VI) reagents was investigated. For this purpose different sulfurane oxides were synthesized. The functionalization of these compounds was unsuccessful due to decomposition or inertness of the ... -
meta-C−H Functionalization and Sustainable Electro- /Photoelectrocatalytic C−H/Si−H/Ge−H Activation
(2024-06-18)C−H activation provides a crucial new tool for the construction of C−C bonds in organic chemical synthesis, especially for agrochemistry, the pharmaceutical industry, and materials science, using a large number of existing ... -
Towards an Effective Synthesis of Functionalized Heptacyclo[6.6.0.02,6.03,13.04,11.05,9.010,14]tetradecane
(2024-03-14)A reassessment of the Rh-catalyzed dimerization of norbornadiene to generate heptacyclo[6.6.0.02,6.03,13.04,11.05,9.010,14]tetradecane (HCTD), a carbocyclic cage compound, has been conducted introducing novel π-acceptor ... -
Application of Gold Catalysis in the Synthesis of Seven-Membered Ring Systems
(2024-01-08)A novel synthetic strategy for the synthesis of seven-membered ring systems with and without heteroatoms applying an Au(I)-based catalyst was successfully established. The selectivity in the cyclization of the corresponding ... -
Weiterentwicklung diffusionsspektroskopischer NMR-Methoden für metallorganische Schlüsselverbindungen
(2023-10-02)This work has extended the development and application of NMR diffusion spectroscopic techniques for the determination of the molecular weight of compounds in solution. In the process, methylcyclohexane-d14 was added to ... -
Barriers of Protonation Reactions of Organometallics
(2023-09-20)Protonation reactions are entirely understood for simple organic and inorganic molecules and there are elaborated concepts to describe such acid-base reactions in both the solution and gas phase. For organometallic species, ... -
Diversity-Oriented Assembly of C-Glycosides via Late-Stage C−H Glycosylation
(2023-08-29)C-glycosides are widely distributed structural motifs found in natural products and commercially available drug molecules. Due to the stability of glycosidic C-C bonds against chemical and enzymatic hydrolysis, only ... -
Bioinspired dioxygen activation with copper complexes supported by Bis(oxazoline) and Bis(benzimidazole) ligands
(2023-06-20)Many synthetic complexes modeling the oxy form of the tyrosinase have been developed and have shown a preference for either the side-on peroxodicopper(II) (P) or the bis(-oxo)dicopper(III) (O) core depending on the ...