Browsing Naturwissenschaften, Mathematik und Informatik by Referee "Hahn, Heidi Prof. Dr."
Now showing items 1-10 of 10
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The role of Wnt signalling in the microtubule-mediated maintenance of chromosomal stability
(2024-07-05)Chromosomal instability (CIN) is a major hallmark of cancer and represents a driving force for tumourigenesis, tumour progression, and the development of therapy resistance. CIN can be subdivided into structural CIN ... -
Understanding the role of the transcription factor MGA in primordial germ cell differentiation
(2023-06-20)One of the most crucial cell lineage decisions in mammalian embryos is the differentiation of a few pluripotent epiblast cells into primordial germ cells (PGCs). PGCs are unique for their ability to mature into either sperm ... -
Interaction of the Hedgehog and vitamin D receptor signaling pathways in Patched associated cancers
(2015-05-12)Tumor formation can be linked to the misregulation of the developmentally important Hedgehog (Hh) signaling pathway. In general, Hh signaling is initiated by the secretion of Hh ligands. This is followed by the binding of ... -
NF-ĸB mediated signaling mechanisms in epidermal homeostasis and carcinogenesis
(2013-09-16)The transcription factor NF-κB is a major player in a wide variety of crucial cellular functions such as proliferation, apoptosis, invasion as well as inflammation. However in the human epidermis, opposite, growth inhibitory ... -
Differential gene expression of chemokines in KRAS and BRAF mutated colorectal cell lines: Role of cytokines
(2013-06-07)Background: Worldwide, colorectal cancer is the third most common malignancy. The development of the colorectal cancer (CRC) is a multistep process that involves e.g. an accumulation of mutations in tumor-growth promoting ... -
Die Rolle von Wnt5a bei der Regression des Basalzellkarzinoms
(2013-01-04)Basal Cell Carcinomas (BCCs) are the most commonly diagnosed tumors among people in the western world. Interestingly, approximately 20% of BCCs show signs of spontaneous regression. Regression of BCCs also occurs in ... -
Characterization of the Oncogenic Role of BCL9-2 in Breast Tumorigenesis
(2012-05-16)One of a few highly conserved signaling pathways, which regulate cell proliferation and tissue organization during embryogenesis and in the adult organism, is the Wnt/beta-catenin signaling cascade. The mutations of ... -
Investigations into the regulation of histone H2B monoubiquitination
(2011-10-26)Transcription-associated chromatin modifications are recognized now as important regulators of gene expression. One of them, the monoubiquitination of lysine 120 of histone H2B (H2Bub1), ... -
Epigenetic Regulation of Replication-Dependent Histone mRNA 3 End Processing
(2010-05-06)Cyclin-dependent kinase 9 (CDK9) was shown to be the Ser/Thr kinase that phosphorylates the C-terminal domain (CTD) of the largest subunit of RNA Polymerase II (RNAPII) at serine residue 2 ... -
Molecular and cellular Mechanisms controlling Primordial Germ Cell Migration in Zebrafish
(2006-06-27)In zebrafish, primordial germ cells (PGCs) are specified early in development then migrate to the area where the gonad will form and differentiate into gametes (eggs and sperm). The ...