Browsing Molekulare Medizin by Referee "Johnsen, Steven Prof. Dr."
Now showing items 1-13 of 13
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Endothelial plasticity in fibrosis and epigenetics as a therapeutic target
(2021-11-26)In this thesis, we aim to (1) uncover novel (epi)genetic regulatory mechanisms that affect endothelial plasticity as an underlying cause of organ fibrosis, and (2) to therapeutically target (epi)genetic regulatory ... -
Molecular mechanisms of TBX5-related conduction disorders
(2021-08-24)Background Cardiovascular disease is a common cause of death. About 60 % of cardiovascular mortality is attributable to sudden cardiac death, mostly caused by arrhythmia. The origin of arrhythmia can be an underlying ... -
RNA methylation in Cardiac Hypertrophy and Heart Failure
(2020-11-06)Cardiovascular diseases (CVDs) are the leading cause of hospital admission and mortality worldwide. Heart failure (HF) is one of the most common CVDs and is characterized by a reduced cardiac function and left ventricular ... -
Role of stromal SPARC in PDAC tumorigenesis and drug delivery
(2019-11-13)Pancreatic ductal adenocarcinoma (PDAC) is one of the most aggressive solid tumors in humans. Median survival is around 12 months and is due to late diagnosis, early metastatic spread, and a high resistance towards available ... -
Stromal and epithelial mechanisms of chemotherapeutic resistance in pancreatic cancer
(2019-05-24)Pancreatic ductal adenocarcinoma (PDAC) is a devastating disease with a 5-year survival rate of less than 8 %. Hallmarks of pancreatic cancer are extensive desmoplasia and strong resistance to standard chemotherapeutic ... -
Using cell type-specific methods to understand molecular processes in the brain
(2019-05-17)Biological causes of many human diseases can be understood more comprehensively by measuring molecular states of the cells. Characterization of cells based on their inherent molecular profiles as well as functional changes ... -
From Chromatin Readers to Heart Failure: BET Protein Family Members in Cardiac Remodeling
(2019-05-16)Heart failure (HF) is the pathologic inability of the heart to supply the body with sufficient amounts of oxygen-rich blood. This increasingly common, life-threatening condition occurs in the final stage of various cardiac ... -
Wnt-TCF7L2-dependent transcriptional and chromatin dynamics in cardiac regeneration, homeostasis and disease
(2018-11-12)Wnt/β-catenin-dependent signaling pathway is indispensible for cardiac development, becoming quiescent in the normal adult heart, and re-activated in both regenerative responses post-injury and in cardiac hypertrophy and ... -
Targeting MDM2, the antagonist of the tumor suppressor p53
(2018-09-19)p53 is one of the most extensively studied tumor suppressor proteins, and its gene is mutated in 50% of human cancers. Stress signals activate p53 and its transcriptional machinery which lead to cell-cycle arrest, apoptosis ... -
Elucidating the pathomechanism behind the neurocristopathy CHARGE syndrome
(2018-02-26)CHARGE syndrome is a complex congenital malformation disorder, caused in more about two-thirds of the cases by heterozygous loss of function mutations in the chromodomain helicase DNA-binding protein 7 (CHD7). The acronym ... -
Development of a Rhesus macaque engineered heart muscle model from pluripotent stem cells
(2017-06-13)Myocardial infarction is the leading cause of death globally. Remuscularization of the heart with stem cell based treatments is one potential approach to heart repair which is presently being tested. Proof-of-concept ... -
Functional relevance of spontaneous alternative splice variants of xeroderma pigmentosum genes: Prognostic marker for skin cancer risk and disease outcome?
(2017-05-05)The nucleotide excision repair (NER) pathway is a central DNA repair mechanism to repair a variety of bulky DNA lesions. Accumulation of these types of damage all over the genome results in the development of a cancer prone ... -
Basic leucine zipper and W2 domain-containing protein 2 (BZW2): A novel cardiac WNT component
(2016-02-11)Tight regulation of the Wnt/β-catenin pathway is crucial not only at all stages of embryonic cardiac development but also for maintaining normal adult heart homeostasis. Indeed, activation of the Wnt/β-catenin signaling ...