Dokumente GGNB - Göttinger Graduiertenzentrum für Neurowissenschaften, Biophysik und molekulare Biowissenschaften nach Erscheinungsdatum
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The Verticillium dahliae Vta3 genetic network and hydrophobins are required in tomato xylem sap for plant disease
(2023-03-27)The ascomycete Verticillium dahliae is a pathogenic fungus for a variety of important crops and spends long phases of its life cycle in the vascular xylem system of particular host plants. Growth in this unique and ... -
Context, circuit and modulation of courtship signal selection in Drosophila
(2023-03-23)Communication is multi-modal -- when we interact, we speak, gesticulate, and touch. However, the neural computations and circuits that select and coordinate these communication signals are unclear. We address this issue ... -
Structure and function of bacterial viruses and viral communities
(2023-03-16)Bacterial viruses, known as bacteriophages or phages, are the most abundant biological entities on the planet and the least studied in terms of abundance and diversity. Searching the sequence databases of viral genomes, ... -
Functional Decomposition of Retinal Ganglion Cell Receptive Fields
(2023-02-23)The retina has the fascinating ability to extract various visual features from our surroundings. This feature detection is enabled by nonlinear operations in the retinal circuitry. The nonlinear processing is in part ... -
The Verticillium effector XFORCE1 targets a core component of plant mRNA turnover and induces cell identity switches
(2023-02-17)Previous research into Verticillium spp. infection on the model plant Arabidopsis thaliana revealed the existence of three distinct disease classes. Each of these could be characterised by the induction of contrasting ... -
Role of predisposing genetics, telomere signaling and crosstalk of cardiac fibroblasts and cardiomyocytes in a pluripotent stem cell model of dilated cardiomyopathy
(2023-02-16)Despite rapid scientific and medical advances, cardiovascular diseases represent a major threat to human health worldwide. Among these, cardiomyopathies are one of the leading causes of heart failure. Dilated cardiomyopathy ... -
Memory capacity of flow network morphology
(2023-02-13)Adaptive flow networks are ubiquitous in our world. From animal blood vasculature to plant water vasculature and organisms shaped as flow networks, Physarum polycephalum, flow networks are abundant in biology with their ... -
Unraveling the Role of TET3 in regulating EndMT in Cardiac Fibrosis
(2023-02-10)DNA methylation and subsequent silencing of gene expression is associated with disease states including tumorigenesis and fibrosis. Although DNA methylation is a dynamic and reversible process, the mechanisms of and ... -
Epitranscriptomic Regulation in Synaptic Plasticity, Aging and Neurodegeneration
(2023-02-03)The regulation of synaptic transmission and plasticity is essential for correct brain function, especially for learning and memory, while the weakening of synaptic transmission and loss of plasticity are hallmarks of the ... -
Sleep control by TFAP2a and TFAP2b transcription factors in mice
(2023-01-31)Sleep is a universal behavior that exists across species. We previously found that deletion of transcription factor APTF-1 induces sleep loss in C. elegans and Drosophila. In mammals, sleep has two states: rapid eye movement ... -
Turbulence Measurements in Flows with Particles
(2023-01-31)Despite the ubiquity of turbulent flows in nature, a general solution to the governing equations of motion remain elusive. These equations are nonlinear and nonlocal, and they describe a chaotic system with multi-scale ... -
Characterization of the Complexin - SNARE Protein Network in Different Synaptic Systems
(2023-01-24)At neuronal synapses, the exocytotic SNARE complex is formed by Syntaxin 1, SNAP25 and Synaptobrevin 2. Complexin (Cplx) regulates the SNARE function to achieve the high speed and spatial precision of synaptic vesicle ... -
Mechanics and Motility of Epithelial Cells: From Single Cell Behavior to Collective Migration
(2023-01-13)Mechanical behavior of cells plays a crucial role in a plethora of biological processes. Despite its importance, this aspect of life science has only more recently gained increasing interest. Yet, without mechanical force ... -
Validation of novel protein-protein interactions in Bacillus subtilis
(2023-01-12)Protein-protein interactions are the basis for many biological processes in the cell. Understanding these interactions is crucial for the general analysis of how the cell functions and the potential identification of ... -
A Minimal Approach to the Dynamic Regulation of Biomolecular Conformation
(2022-12-14)Allostery is the key mechanism enabling a “remote” regulation of the activity of proteins and other biological macromolecules. It forms the basis for controlling various inter- and intracellular processes. Allosteric ... -
Translation Termination in Human Mitochondria: The Role of mtRF1 and mtRF1a
(2022-12-09)Translation termination is the last step of ribosomal protein synthesis. Dedicated translation factors are imported into mitochondria to convert the information stored in the retained mitochondrial DNA (mtDNA) and to ... -
Automated STED microscopy for cell-biological high-throughput assays
(2022-11-28)In the past decade, super-resolution fluorescence microscopy has revolutionized biological research by enabling the study of biological functions down to the molecular scale. Despite profound technological developments, ... -
Functional and Structural Characterization of the DEAH-box Helicase Prp43
(2022-11-24)RNA helicases of the DEAH-box family fulfill essential functions in various aspects of RNA metabolism by reorganizing structured RNAs and RNPs through ATP-dependent motility in 3’ to 5’ direction along single-strands. Prp43 ... -
Prenatal maternal stress effects in wild Assamese macaques (Macaca assamensis)
(2022-11-22)Across mammals, adverse conditions experienced during specific ontogenetic sensitive periods can have persisting effects on neurodevelopment, acquisition of cognitive and motoric skills, immune function, and systemic ... -
Cystic Fibrosis as a model use case for implementing cell based disease models in systems medicine
(2022-11-22)In the last two decades, tremendous progress has been made in producing large amounts of biological and biomedical data in a time- and cost-effective manner. Along with the increasing amount of data has come the requirement ...