Browsing GGNB - Göttinger Graduiertenzentrum für Neurowissenschaften, Biophysik und molekulare Biowissenschaften by Referee "Nave, Klaus-Armin Prof. Dr."
Now showing items 21-32 of 32
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Neue Behandlungsansätze für neuropsychiatrische Erkrankungen basierend auf der Identifizierung molekularer Krankheitsdeterminanten
(2009-04-21)Major neuropsychiatric diseases, including schizophrenia and bipolar disorder, deteriorate higher brain functions leading to disorganized thinking and cognitive decline. Available treatments ... -
"Eine neue Rolle für Myelin-assoziierte Inhibitoren für die Mobilität von Mikroglia"
(2009-05-28)In the central nervous system of mammals, the regeneration of axons after injury is limited. The reduced ability of neurite outgrowth can be attributed, in part, to the presence of inhibitor proteins enriched in myelin. ... -
Neurovascular coupling in a central nervous system white matter tract
(2022-08-08)Neurovascular coupling is the process by which blood vessels dilate upon increased neuronal activity. It has been extensively studied in the murine grey matter and there are several models explaining possible molecular ... -
Pathways for phospholipid deacylation in Saccharomyces cerevisiae and their impact on fatty acid trafficking and equilibrium
(2011-01-25)The phospholipid (PL) class and species composition is a fundamental characteristic of membranes, essential to their proper function. The PL species distribution of cellular lipids is only ... -
Sleep control by TFAP2a and TFAP2b transcription factors in mice
(2023-01-31)Sleep is a universal behavior that exists across species. We previously found that deletion of transcription factor APTF-1 induces sleep loss in C. elegans and Drosophila. In mammals, sleep has two states: rapid eye movement ... -
The EPO/EPOR system in the brain: Search for mechanisms of action
(2014-04-17)Erythropoietin (EPO) and its receptor (EPOR) are known to be essential for erythropoiesis. However, the EPO/EPOR system turned out to have additional important functions in non-hematopoietic tissue. The brain is one of the ... -
The influence of common infections on clinical course and neurodegeneration in an animal model of multiple sclerosis
(2015-03-05)The course of Multiple Sclerosis (MS), a chronic autoimmune disease, can be influenced by systemic infections. The common notion is that bacterial infections worsen disease symptoms and lead to enhanced neurodegeneration. ... -
The molecular mechanisms of myelin disassembly
(2016-08-26)Myelin is characterized by stacking of multiple layers of membrane compacted by MBP. The breakdown of myelin is a pathological hallmark of several autoimmune diseases of the nervous system. To assess the myelin fragmentation ... -
The role of bHLH transcription factor NEX in neuronal differentiation and experience-dependent plasticity
(2008-02-12)NEX (neuronal helix-loop-helix protein) is an atonal-related basic helix-loop-helix (bHLH) transcription factor that belongs to the subfamily of neuronal differentiation factors, which also includes NeuroD and NDRF. NEX ... -
The role of E3 ubiquitin ligase FBXO31-SCF in neuronal morphogenesis
(2013-01-03)Neuronal development is coordinated by the interplay of extrinsic cues and intrinsic factors. These extrinsic cues act through multiple intracellular signaling pathways to regulate the cytoskeleton machinery of the ... -
The Role of Phosphoinositides in the Interaction of Myelin Basic Protein with the Oligodendroglial Cell Membrane
(2010-02-09)The only protein known to be essential for myelin formation and compaction in the central nervous system is myelin basic protein (MBP). Oligodendrocytes in mutant mice that lack MBP-expression ... -
White matter integrity of the frontal brain and its relevance for catatonia and executive function
(2021-11-22)Catatonia is a CNS derived psychomotor syndrome comprising disturbed volition and aberrant motor and behavioral features. Targeted and effective treatment today is scarce and further impeded by its heterogeneous clinical ...