Browsing GGNB - Göttinger Graduiertenzentrum für Neurowissenschaften, Biophysik und molekulare Biowissenschaften by Advisor "Brose, Nils Prof. Dr."
Now showing items 1-14 of 14
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Characterization of the Complexin - SNARE Protein Network in Different Synaptic Systems
(2023-01-24)At neuronal synapses, the exocytotic SNARE complex is formed by Syntaxin 1, SNAP25 and Synaptobrevin 2. Complexin (Cplx) regulates the SNARE function to achieve the high speed and spatial precision of synaptic vesicle ... -
Resolving Dopamine Secretion at Individual Varicosities using Carbon Nanotube-Based Optical Dopamine Nanosensors
(2021-07-23)Dopamine (DA) is a neurotransmitter that controls vital brain functions such as motor control and motivation, but little is known about the molecular mechanisms that control DA release. Neurotransmission through DA differs ... -
Molecular Mechanisms Involved In The Generation Of Inhibitory Postsynaptic Structures
(2021-07-07)In the work presented here, a set of full-length size-selected and unamplified cDNA expression libraries [30.000 CFU in total; size-fractionated into 2-3, 3-4, and 4-5 kb pools of 10.000 CFU each] was screened for proteins ... -
Functional Analysis of E3 Ubiquitin Ligases in Developing Neurons
(2019-08-15)Neuronal development starts after the closure of the neural tube when neural stem cells begin to divide asymmetrically at the ventricular zone of the forebrain. Newborn neurons then migrate vertically from the ventricular ... -
Role of adhesion proteins Neuroligin 2 and IgSF9b in the amygdala anxiety circuitry
(2018-04-23)Anxiety disorder is a debilitating condition that affects up to 10% of the adult population in the world. Mapping of brain activity in patients and in mouse models has shown that anxiety- related behavior is associated ... -
Electrophysiological Analysis of the Synaptic Vesicle Priming Process
(2017-08-17)Chemical synaptic transmission is the most prominent communication channel employed by neural circuits. It is initiated by the action potential triggered fusion of transmitter-filled synaptic vesicles with the presynaptic ... -
Roles of the Nedd4 Family E3 Ligases in Glial Function and Nerve Cell Development
(2017-05-09)Protein ubiquitination is one of the core regulatory post-translational modification in neuronal development. In this study, we used brain specific KO mice to identify novel substrate proteins of several Nedd4 family E3 ... -
Role of Munc13 Isoforms in Regulating Large Dense Core Vesicle Exocytosis in Chromaffin Cells
(2015-11-03)The process of vesicular exocytosis is a fast, tightly regulated and Ca2+-triggered event mediated by SNARE complex formation. Although it is known that factors like Munc18, Munc13 and CAPS are important in setting up ... -
Molecular and Morphological Correlates of Synaptic Vesicle Priming
(2014-10-27)Excitation-secretion coupling at nerve cell synapses is a sub-millisecond process that entails the transduction of an electrical stimulus into synaptic vesicle fusion. Before fusion, synaptic vesicles are physically docked ... -
Molecular mechanisms of collybistin-dependent gephyrin clustering at inhibitory synapses
(2014-07-03)Information processing and transmission in neuronal networks in the mammalian brain occurs through intercellular communication between neurons at synapses. Inhibitory synapses play a key role, for example to maintain network ... -
Characterization of neuroligin 4, a protein involved in autism spectrum disorders
(2012-11-06)Neuroligins (NLs) are ubiquitous postsynaptic adhesion proteins that are essential for synaptic maturation and function. Of the four NL isoforms expressed in the central nervous system (CNS), NL4 is of particular interest ... -
Characterization of the Munc13 - CaM Interaction
(2009-07-06)The Munc13 proteins are the key mediators of synaptic vesicle priming, an essential step in Ca2+-regulated neurotransmitter release that renders docked vesicles fusion-competent prior to ... -
The Role of alpha- and beta-SNAP in Synaptic Vesicle Exocytosis
(2008-08-04)Neurotransmitter release is mediated by the neuronal SNARE proteins, which are transmembrane proteins whose assembly into ternary complexes is thought to drive membrane fusion of synaptic ... -
The role of bHLH transcription factor NEX in neuronal differentiation and experience-dependent plasticity
(2008-02-12)NEX (neuronal helix-loop-helix protein) is an atonal-related basic helix-loop-helix (bHLH) transcription factor that belongs to the subfamily of neuronal differentiation factors, which also includes NeuroD and NDRF. NEX ...