Browsing GGNB - Göttinger Graduiertenzentrum für Neurowissenschaften, Biophysik und molekulare Biowissenschaften by Referee "Dresbach, Thomas Prof. Dr."
Now showing items 1-20 of 30
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Illuminating the Morphological and Functional Plasticity of the Cochlear Inner Hair Cell Ribbon Synapse
(2023-10-24)Sound detection occurs in the cochlea, where sensory inner hair cells (IHC) accurately convert auditory stimuli into a neurochemical signal. Presynaptically, cochlear IHCs harbor highly-specialized electron-dense specializations ... -
Quantitative Multicolour Nanoscopy for the Investigation of the Postsynaptic Actin Cytoskeleton
(2023-08-16)Cognitive processes like the formation of memory and learning originate in the correct functioning of synapses. Dendritic spines are highly plastic, specialised actin-rich structures harbouring the postsynaptic site in ... -
Pathophysiological effects of Beta-Synuclein mutants P123H and V70M
(2023-07-24)Mutations in the beta-synuclein protein have been directly linked to Dementia with Lewy bodies (DLB). In particular, P123H mutation was linked to a familial case of DLB, whereas V70M mutation was identified in a sporadic ... -
Excitation-Secretion Coupling of Dense-Core Vesicle Release
(2023-07-18)Dense-core vesicles (DCVs) are membrane-bound organelles present in many secretory cells. Depending on cell type, DCVs package and release various types of cargo, such as neuronal peptides, proteins, neurotrophins, ATP, ... -
The influence of epigenetic alterations on synaptic function and memory
(2022-08-24)While memory formation is traditionally linked to changes in synaptic structure, the transcriptional processes enabling these changes are often understudied. Even though novel protein synthesis is the basis of long-term ... -
Multi-omic analysis of the aging mouse brain
(2021-12-23)Brain function is highly dependent on a well-regulated, harmonic interaction of a multitude of cellular and molecular pathways. During aging, many of these pathways undergo progressive changes, leading to gradual deterioration ... -
Molecular physiology of sound encoding
(2021-10-26)Inner hair cells (IHC) are responsible for transforming mechanical sound-borne vibrations into electrical signals and conveying this information to the afferent spiral ganglion neurons (SGNs). Upon stimulation, the receptor ... -
Molecular Mechanisms Involved In The Generation Of Inhibitory Postsynaptic Structures
(2021-07-07)In the work presented here, a set of full-length size-selected and unamplified cDNA expression libraries [30.000 CFU in total; size-fractionated into 2-3, 3-4, and 4-5 kb pools of 10.000 CFU each] was screened for proteins ... -
α-synuclein disrupts neuron network rhythmic activity when overexpressed in cultured neurons
(2021-03-09)Synucleinopathies are associated with a generalized slowing of the brain’s rhythmic activity, which co-occurs with dementia and has been connected with increased levels of α synuclein in both patients and test animals. In ... -
Cortical patterning and neuronal migration are under the guide of BAF complex functionality
(2020-03-26)The brain is one of the complex organs designed under the control of a plethora of molecular and cellular regulatory mechanisms, including transcriptional and epigenetic pathways. Brain organogenesis proceeds in a stepwise ... -
Wiring and information processing in the olfactory bulb of larval Xenopus laevis
(2020-02-04)Olfactory systems of vertebrates have adapted to the various challenges of their environments on both the level of odorant receptors and neuronal wiring. Amphibians like the African clawed frog Xenopus laevis offer a ... -
Morphological Studies of Synaptic Vesicle Recycling at the Inner Hair Cell Ribbon Synapse
(2020-01-10)Within the mammalian inner ear, sensory inner hair cells (IHCs) of the organ of Corti are required to transduce sound waves into electrical signals. Specialized synapses at the IHC basal pole, so-called ribbon synapses, ... -
A guardian of balance: the role of BAF chromatin remodeling complex in astrogliogenesis during mouse forebrain development
(2019-12-20)In the human central nervous system, astrocytes vastly outnumber neurons and regulate a host of physiological processes critical to its function. Astrocytes form a functional syncytium tiling the brain with minimal overlap ... -
Functional Analysis of E3 Ubiquitin Ligases in Developing Neurons
(2019-08-15)Neuronal development starts after the closure of the neural tube when neural stem cells begin to divide asymmetrically at the ventricular zone of the forebrain. Newborn neurons then migrate vertically from the ventricular ... -
The presynaptic protein Mover is heterogeneously expressed across brain areas and synapse types
(2019-06-24)Synaptic nerve terminals are highly specialized sites where complex processes are taking place. The regulation of these complex processes is mediated by an intricate machinery of presynaptic proteins. While most of these ... -
Dual-AAV mediated transfer of full-length otoferlin cDNA into auditory inner hair cells and the effects of different mutations in the OTOF gene on the protein levels and cellular distribution of otoferlin in auditory inner hair cells
(2019-05-08)Otoferlin is a large multi-C2 domain protein indispensable for hearing and synaptic transmission in auditory inner hair cells (IHCs). Mutations within the OTOF gene, coding for otoferlin, cause non-syndromic recessive ... -
Changes in gene expression linked to Alzheimer's disease and "healthy" cognitive aging
(2019-02-20)Alzheimer’s disease (AD) is a neurodegenerative disease and the most common form of dementia. The number of AD cases increases exponentially every year. Although AD has been investigated for a long time, the precise ... -
Mechanisms underlying the temporal and selective induction of Ptf1a target genes
(2019-01-30)The bHLH transcription factor Ptf1a is crucial for the generation of a GABAergic neuronal cell fate over an excitatory glutamatergic fate. Ptf1a is a component of a heterotrimeric transcription factor complex, which in ... -
Ultrafast Multichannel Optogenetic Stimulation of the Auditory Pathway for Optical Cochlear Implants
(2019-01-14)In case of profound sensorineural hearing loss and deafness, cochlear implants (CIs) partially restore hearing and provide missing auditory information to the brain. Electrical stimulation of the spiral ganglion neurons ... -
The role of N-truncated Aβ peptides in Alzheimer’s Disease
(2018-06-29)The N-terminally truncated pyroglutamate Aβ3−42 (AβpE3−42) and Aβ4−42 peptides are known to be highly abundant in the brain of Alzheimer’s disease (AD) patients. Both peptides show enhanced aggregation and neurotoxicity ...