Browsing GGNB - Göttinger Graduiertenzentrum für Neurowissenschaften, Biophysik und molekulare Biowissenschaften by Referee "Fasshauer, Dirk Prof. Dr."
Now showing items 1-9 of 9
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Structural and functional studies of the spliceosomal RNP remodeling enzyme Brr2
(2013-06-25)The spliceosome is a highly dynamic, multi-MDa eukaryotic RNA-protein (RNP) machinery that catalyzes precursor messenger RNA (pre-mRNA) splicing. Pre-mRNA splicing entails the excision of non-coding introns and the joining ... -
Genomics and Phylogeny of Cytoskeletal Proteins: Tools and Analyses
(2013-02-05)Evolution of the eukaryotic dynactin complex, the activator of cytoplasmic dynein: Background Dynactin is a large multisubunit protein complex that enhances the processivity of cytoplasmic dynein and acts as an adapter ... -
Sec1p/Munc18 (SM) proteins and their role in regulating secretion in Saccharomyces cerevisiae and Caenorhabditis elegans a comparative approach
(2013-01-04)The members of the Sec1p/Munc18 (SM) family of proteins are indispensible regulatory elements that act at the post-docking step prior to fusion; they exert their function mainly through their interaction to the Qa-SNAREs ... -
Structural and Functional Analysis of the Mitochondrial Presequence Translocase
(2012-09-14)The yeast, Saccharomyces cerevisiae, mitochondrial proteome consists of approximately 1000 proteins, most of which are synthesized on cytosolic ribosomes and therefore require specialized transport systems to reach their ... -
Comparative studies on regulation of SNARE complex formation by the SM protein Sly1p
(2012-06-11)Sec1/ Munc18 (SM) proteins are indispensible regulators of intracellular membrane fusion. In general, the high-affinity binding partners of SM proteins are Qa-SNAREs (syntaxins). Despite the high structural homology ... -
Phylogenetic studies of the vesicular fusion machinery
(2010-10-01)The eukaryotic cell consists of a large system of membrane delimited compartments. Material exchange between these compartments is mediated by intracellular trafficking vesicles. These ... -
Subcellular localization of Kv10.1 (Eag1): functional ion channels on the inner nuclear membrane
(2010-07-01)hEag1 (human ether-a-go-go-1, Kv10.1) is a voltage-gated potassium channel expressed mostly in the brain in healthy subjects but also in many tumors under pathological conditions. Its ability ... -
Structural and functional analysis of the NusB-S10 complex shared between transcription and translation
(2010-06-07)Transcription and translation are two highly coupled processes during prokaryotic gene expression where ribosomes initiate translation on mRNAs already during transcription, in contrast to ... -
Vergleichende Untersuchungen zur Regulation der SNARE-Komplexbildung durch Sec1/Munc18-Proteine
(2009-07-01)Membrane fusion events between various intracellular compartments in eukaryotic cells are mediated by two conserved protein families: SNARE- and Sec1/Munc18 (SM)-proteins. The SNARE ...