Browsing GGNB - Göttinger Graduiertenzentrum für Neurowissenschaften, Biophysik und molekulare Biowissenschaften by Referee "Janshoff, Andreas Prof. Dr."
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Interactions between cytoskeletal filaments in cells
(2024-10-04)Essential functions of eukaryotic cells such as cell division, force generation and the ability to mechanically adapt to the outer environment depend on the cytoskeleton, which is an intricate network containing three ... -
Bayesian Inference for Top-Down Protein Markov Models and the Ubiquity of Michaelis-Menten Kinetics
(2024-10-04)The current understanding of protein function predominantly relies on the concept of describing proteins as comprising discrete conformational and chemical states including transitions between these states. The theory of ... -
Turbulence Measurements in Flows with Particles
(2023-01-31)Despite the ubiquity of turbulent flows in nature, a general solution to the governing equations of motion remain elusive. These equations are nonlinear and nonlocal, and they describe a chaotic system with multi-scale ... -
Mechanics and Motility of Epithelial Cells: From Single Cell Behavior to Collective Migration
(2023-01-13)Mechanical behavior of cells plays a crucial role in a plethora of biological processes. Despite its importance, this aspect of life science has only more recently gained increasing interest. Yet, without mechanical force ... -
Automated STED microscopy for cell-biological high-throughput assays
(2022-11-28)In the past decade, super-resolution fluorescence microscopy has revolutionized biological research by enabling the study of biological functions down to the molecular scale. Despite profound technological developments, ... -
The Dynamic Organization of Proteins in the Synaptic Bouton
(2022-09-12)Protein availability is crucial for maintaining cellular processes. In synapses, the identities and functions of proteins involved in neurotransmission are well known. Their spatial distribution, copy numbers, and lifetimes ... -
Molecular characterization of protein-dependent lipid transport during mitochondrial biogenesis
(2022-05-18)Mitochondria are comprised of two membranes, each with a unique lipid and protein composition, subdividing this organelle into the outer mitochondrial membrane (OMM), the intermembrane space (IMS), the inner mitochondrial ... -
Intermediate filament mechanics across scales
(2022-02-24)The mechanical properties of cells are largely determined by the cytoskeleton. The cytoskeleton is an intricate and complex structure formed by protein filaments, motor proteins, and crosslinkers. The three main types of ... -
Mechanics and Dynamics of <i>Dictyostelium discoideum</i> adhesion
(2021-09-28)The amoeba Dictyostelium discoideum (D.d.) is an excellent laboratory model system for studying amoeboid adhesion. In its natural habitat, D.d. lives in the soil and hunts for bacteria, an environment, which ... -
Vimentin Intermediate Filament Softening - Recovery Behavior and Post-Translational Modifications
(2021-09-16)The capability of eukaryotic cells to resist large deformations, to transport intracellular cargo and to adapt the cell shape, for example during migration, depends on the cytoskeleton, a composite network of three types ... -
Structure and Mechanics of Neuronal Model Systems
(2019-11-15)Neurons of advanced animals need fast and efficient mechanisms to enable the functionality of a complex nervous system. In the life cycle of synaptic vesicles this is reflected in the endocytosis which generates new vesicles, ... -
Collective Mechanical Behavior of Epithelial Cells - The Impact of Micro-Wounding
(2019-06-24)For epithelia, which are lining organs or blood vessels, the mechanical integrity of a whole cell sheet is indispensable. The question arises, how neighboring cells mechanically work together to build a functioning cell ... -
Extending Resolution in All Directions: Image Scanning Microscopy and Metal-induced Energy Transfer
(2019-03-18)Fluorescence microscopy is a powerful tool in the life sciences and is used to study structure and function on length scales from cells down to single molecules. In recent years, fluorescence microscopy has seen enormous ... -
Cortical Tension of Cells: From Apical Membrane Patches to Patterned Cells
(2018-12-05)During their lifetime, cells and tissues have to deal with a variety of mechanical challenges. Shear forces exist inside of vessels, bones have to carry the weight of organisms and connective tissues are generally deformed ... -
Stress-Strain Behavior of Single Vimentin Intermediate Filaments
(2018-08-09)Cells are the basic unit of living organisms and consist of a cytoplasm, which is enclosed by a membrane. As building blocks of life with a plethora of functions, cells have to be equipped with a high degree of mechanical ... -
Active and Passive Microrheology of F-Actin Membrane Composites
(2018-07-19)The complex mechanical properties of a living cell are not only a function of its structural components but also of the organizational super-structure and the dynamic interconnection of filaments, proteins and the plasma ... -
Study of SNARE-mediated membrane fusion with a novel single vesicle fusion assay
(2018-06-12)Membrane fusion in the secretory pathway of eukaryotic cells, including exocytosis of synaptic vesicles, is catalysed by SNARE proteins. In case of the synaptic vesicle fusion, two of the members of this protein family ... -
Molecular Details of Membrane Deformation by ENTH Domains
(2018-03-20)During clathrin mediated endocytosis (CME) cargo molecules are transported across the plasma membrane from the outer cell surface into the cytosol. In this process, the plasma membrane undergoes massive local remodeling ... -
Membrane tension homeostasis of mammalian cells
(2017-04-12)Although a cell is the smallest unit that is viable on its own, its construction and processes are of great complexity. Many functions, which keep a cell alive, are only poorly understood up to now. Plasma membrane tension ... -
Biogenesis and maintenance of cytoplasmic domains in myelin of the central nervous system
(2017-02-27)Myelin is a multi-lamellar membrane structure, produced by oligodendrocytes which are special glial cells, that myelinate axons in the central nervous system (CNS) (Aggarwal, Yurlova, & Simons, 2011; Vassall, Bamm, & Harauz, ...