Browsing GGNB - Göttinger Graduiertenzentrum für Neurowissenschaften, Biophysik und molekulare Biowissenschaften by Referee "Nave, Klaus-Armin Prof. Dr."
Now showing items 1-20 of 33
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Sleep control by TFAP2a and TFAP2b transcription factors in mice
(2023-01-31)Sleep is a universal behavior that exists across species. We previously found that deletion of transcription factor APTF-1 induces sleep loss in C. elegans and Drosophila. In mammals, sleep has two states: rapid eye movement ... -
Multi-contrast Magnetic Resonance Imaging of Myelin and Iron in the Brain
(2022-09-27)The non-invasive characterization of brain myelin has essential applications in basic neuroscience and the clinical management of white matter brain diseases and other inflammatory and neurodegenerative diseases. Magnetic ... -
Neurovascular coupling in a central nervous system white matter tract
(2022-08-08)Neurovascular coupling is the process by which blood vessels dilate upon increased neuronal activity. It has been extensively studied in the murine grey matter and there are several models explaining possible molecular ... -
Ageing-associated myelin dysfunction as a driver of amyloid deposition in Alzheimer’s disease
(2022-01-07)Alzheimer’s disease (AD) is the most common neurodegenerative disease with increasing prevalence due to longer lifespans in the human population. AD manifests as various age-associated cognitive impairments summarised under ... -
White matter integrity of the frontal brain and its relevance for catatonia and executive function
(2021-11-22)Catatonia is a CNS derived psychomotor syndrome comprising disturbed volition and aberrant motor and behavioral features. Targeted and effective treatment today is scarce and further impeded by its heterogeneous clinical ... -
Establishing parameters for the characterization of rare neurometabolic and neurodegenerative diseases using mass-spectrometry based Metabolomics
(2021-10-18)Rare diseases are a class of disorders where every single disease has a low prevalence, but due to their incredible variety, they affect more than 100 million people worldwide. A significant number of these disorders lead ... -
Erythropoietin as a driver of neurodifferentiation, neuroplasticity and cognition – A continuum view of the neuronal lineage
(2019-12-05)Erythropoietin (EPO), named after its role in hematopoiesis, has been best studied in the hematopoietic system. Studies emphasizing the expression of EPO in the central nervous system have sparked an interest in its role ... -
Evaluating the function of the Aryl Hydrocarbon Receptor in CNS autoimmunity
(2018-12-07)The aryl hydrocarbon receptor (AhR) is a ligand activated transcription factor highly expressed within the immune and nervous system. Structurally diverse endogenous and synthetic ligands activate AhR, including dietary, ... -
Lysosomal and mitochondrial crosstalk: the role of lysosomal signaling on mitochondrial biogenesis and function
(2018-11-15)Defects in metabolism result in various diseases, with neurodegeneration being one of the most prevalent consequences. Mitochondria and lysosomes are long known to be fundamental for cellular metabolism. In addition to ... -
Genetic and autoimmune modulators of brain function in neuropsychiatric illness and health
(2018-06-15)In the present thesis, the synergetic interaction between the nervous and immune systems and the potential pathological outcomes mediated by autoimmune processes targeting the brain was addressed, with a particular focus ... -
A novel role for the E3 ubiquitin ligase FBXO7 in axon-myelin interaction
(2018-06-06)The regulated turnover of proteins is an essential aspect of every cell. Cells must be able to respond to environmental changes or undergo different developmental stages, while still maintaining a balanced protein homeostasis. ... -
BAF155 regulates the genesis of basal progenitors through both Pax6-dependent and independent mechanisms during cerebral cortex development
(2018-04-10)During mammalian development, the balance between symmetric and asymmetric division of radial glial (RG) progenitors regulates the tangential size versus radial growth of the cerebral cortex. The pool of basal progenitors ... -
The molecular mechanisms of myelin disassembly
(2016-08-26)Myelin is characterized by stacking of multiple layers of membrane compacted by MBP. The breakdown of myelin is a pathological hallmark of several autoimmune diseases of the nervous system. To assess the myelin fragmentation ... -
Actin turnover regulates mechanical properties of oligodendrocytes and myelin formation
(2015-10-02)The myelin sheath is a specialized membranous structure that facilitates rapid signal conduction along axonal segments. During central nervous system development, it is formed by oligodendrocytes that extend motile and ... -
The influence of common infections on clinical course and neurodegeneration in an animal model of multiple sclerosis
(2015-03-05)The course of Multiple Sclerosis (MS), a chronic autoimmune disease, can be influenced by systemic infections. The common notion is that bacterial infections worsen disease symptoms and lead to enhanced neurodegeneration. ... -
The EPO/EPOR system in the brain: Search for mechanisms of action
(2014-04-17)Erythropoietin (EPO) and its receptor (EPOR) are known to be essential for erythropoiesis. However, the EPO/EPOR system turned out to have additional important functions in non-hematopoietic tissue. The brain is one of the ... -
Dynamic regulation of myelin genes in wild type and SHARP1 and -2 double null-mutant mice
(2013-12-19)In living organisms, a molecular clockwork synchronises physiological mechanisms with daily recurrent changes in the environment, a process that is termed entrainment. The two basic helix-loop-helix (bHLH) transcription ... -
Molecular correlates of spinal motor neuron functional specification and plasticity
(2013-07-30)The precision with which motor neurons connect to functionally matched muscle fibers ultimately determines the accuracy of behavioural outputs. Motor neurons are functionally diverse and can be subdivided into distinct ... -
The role of innervation during mouse embryonic myogenesis: what molecular genetics tells
(2013-06-19)The interdependency of motor neurons and the skeletal muscle is a classical example for instructive and trophic tissue interactions during development and adult life. It is well established that skeletal muscles undergo ... -
Exploring the neural basis of touch through selective and stable genetic tagging in the chick somatosensory system
(2013-01-03)The assembly of circuitries for somatosensory perception relies on a complex interplay of neuronal diversification, specification, phenotypic modulation and establishment of precise connectivity patterns during embryogenesis. ...