Browsing GGNB - Göttinger Graduiertenzentrum für Neurowissenschaften, Biophysik und molekulare Biowissenschaften by Referee "Stühmer, Walter Prof. Dr."
Now showing items 1-17 of 17
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On the Speed of Neuronal Populations
(2017-10-10)This thesis presents novel results in the areas of closed loop electrophysiology and neuronal population coding. This work begins by presenting the first known attempt to control the spike rate of a neuron or neurons using ... -
Determination of the Dynamic Gain Function of Cortical Interneurons with distinct Electrical Types
(2017-04-25)In the living brain, individual neurons are constantly bombarded by thousands of synaptic inputs, which results in a fluctuating membrane potential. Neurons under such conditions are said to operate in a “fluctuation-driven ... -
Glomerular information processing in Xenopus laevis
(2016-08-30)Olfactory glomeruli are structural and functional neuropils in the olfactory bulb. Although many olfactory receptor neurons (ORNs) project to one glomerulus, stimulusinduced responses within single glomeruli could not ... -
Roles of PSD-93 and environmental enrichment in cortical synapses
(2015-11-10)During neurodevelopment several structural, molecular and functional changes take place in the brain to promote its maturation. These changes occur at multiple levels, including changes in protein expression, in the strength ... -
Dinamics of Kv10.1 expression through the cell cycle of cancer and non-cancer cells
(2015-05-12)Kv10.1 is a voltage dependent potassium channel. Its expression has been reported to be widespread in clinical tumors samples of diverse origin. In contrast, expression in normal non-neural tissue has been detected at low ... -
Studies of cultured neuronal networks using light activated ion channels and pumps
(2013-02-26)In the presented thesis work, an “Optical Network Electrophysiology “ system that combines optical stimulation using optogenetic tools and multisite neuronal recording using microelectrode arrays was developed and its ... -
Modulation of synaptic transmission by the voltage-gated potassium channel Eag1
(2012-06-18)The voltage-gated potassium channel Kv10.1 is widely expressed in the mammalian brain, but its function has not been described. Previous studies revealed highest expression levels in hippocampus and cerebellum and suggested ... -
Role of Histone Methylation in Cognition and Effects of Different Durations of Environmental Enrichment on Learning and Memory
(2012-06-06)Part 1 Formation of stable long-term memories requires novel gene expression, and chromatin modifications have been shown to be involved in mediating the de novo gene expression which is necessary for memory formation. ... -
Optical analysis of synaptic vesicle protein molecules during exo- and endocytosis using pH-switchable fluorescent probes
(2011-11-22)At conventional synapses of the central nervous system (CNS), fast synaptic transmission is mediated by the release of neurotransmitters (NTs) upon Ca2+-triggered synaptic vesicle (SV) ... -
Analysis of the RAB family of GTPases in C. elegans and their role in regulating neuronal membrane trafficking
(2011-05-03)Rab GTPases are master regulators of intracellular trafficking. They are involved in every aspect of membrane transport from vesicle budding to vesicle fusion. Their functions are regulated ... -
Transduction in Olfactory Receptor Neurons of Xenopus laevis Larvae: Pharmacological Blockage with FM1-43 and Endocannabinoid Modulation
(2010-09-29)The sense of smell is critical for finding food and mediating emotional and social responses. A dysfunction of this sense is often associated with diseases. In the last two decades much ... -
Quantitative analysis of Förster resonance energy transfer from spectrally resolved fluorescence measurements
(2010-08-25)A novel method for spectral analysis of Forster resonance energy transfer (FRET) signals is presented. This method provides a general solution for donor quenching and acceptor sensitization ... -
Investigation of Sip1 gene interactions in the development of the mammalian telencephalon
(2010-08-02)The transcriptional repressor Sip1, or Smad- interacting protein 1, has been shown to play a key role in early neurodevelopment. Mowat- Wilson Syndrome in humans is associated with mutations ... -
Subcellular localization of Kv10.1 (Eag1): functional ion channels on the inner nuclear membrane
(2010-07-01)hEag1 (human ether-a-go-go-1, Kv10.1) is a voltage-gated potassium channel expressed mostly in the brain in healthy subjects but also in many tumors under pathological conditions. Its ability ... -
Quantitation Strategies in Optically Sectioning Fluorescence Microscopy
(2009-06-15)The development of microscopes that can record fluorescence intensity in five and more dimensions in one experiment (e.g. space, time and colour) makes parameters available for the scientific ... -
Glutamate-induced reversal of dopamine transport is mediated by the PKC signalling pathway
(2009-04-16)Dopaminergic neurons release their transmitter not only from axon terminals in the striatum but also from their long apical dendrites in the substantia nigra pars reticulata (SNr). Whether ...