Blättern Human- und Zahnmedizin nach "Brück, Wolfgang Prof. Dr." Betreuer
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Die Auswirkungen des selektiven Androgenrezeptor-Modulators Enobosarm auf die Skelettmuskulatur der orchiektomierten Ratte
(2020-03-23)Osteoporosis and sarcopenia are closely related diseases, which together affect our musculoskeletal system. Long researched as female diseases, the potential therapeutic effects of the selective androgen receptor modulator ... -
Axonpathologie in Immunsubtypen von Multiple-Sklerose-Läsionen
(2013-10-30)Multiple sclerosis (ms) is an inflammatory demyelinating disease of the central nervous system leading to axonal damage. The axonal damage correlates with the degree of clinical disabillity in ms patients. Lucchinetti et ... -
Die Bedeutung der transösophagealen Echokardiographie beim Schlaganfall - Ergebnisse einer großen monozentrischen Querschnittsstudie
(2021-02-18)Strokes are one of the leading causes of death worldwide. Despite intensified diagnostics, the majority of strokes must be classified as cryptogenic. In this context the role of a PFO with or without ASA seems unclear and ... -
Charakterisierung von Peroxiredoxin 2 im zentralen Nervensystem bei Multipler Sklerose
(2021-10-21)Multiple sclerosis (MS) is a chronic inflammatory disease of the central nervous system, characterized by demyelination and axonal damage as well as neuronal degeneration. Oxygen-derived free radicals are an important ... -
Der Einfluss unterschiedlicher Zellkulturmedien auf die Makrophagen in einem Co-Kultur-Modell von Nervengewebe und Peritonealzellen
(2014-05-08)During Wallerian degeneration in the central or peripheral nervous system the migration of macrophages to the injured tissue can be observed. Then these cells phagocytize the accruing myelin and axon debris at the injury ... -
Evaluation of the cuprizone model
(2008-04-07)This work on the cuprizone model was intended to establish the cuprizone mouse model and to characterize pathologic changes that are relevant to human demyelinating diseases. This animal model is characterized by ... -
From the morphological to the integrated diagnosis of diffuse gliomas – a retrospective study
(2023-08-03)From the first classification of brain tumors by Rudolf Virchow in 1863 to our most recent WHO 2016 Classification, more than 150 years have passed. Within that time period, our understanding and scientific progress has ... -
Immunologische und molekulare Profile von "smoldering lesions" der Multiplen Sklerose
(2017-05-18)Multiple sclerosis (MS) is a chronic-inflammatory disease of the central nervous system. It is characterized by progressive demyelination for which no effective therapy has yet been established. Characteristics of the ... -
Kortikale Demyelinisierung bei entzündlichen, neoplastischen und metabolischen ZNS-Erkrankungen
(2018-11-06)Cortical demyelinated lesions are frequent and widespread in chronic multiple sclerosis (MS) patients, and may contribute to disease progression. Cortical and subpial lesions were found in early MS stages indicating that ... -
Das lymphozytäre Entzündungsinfiltrat in Multiple-Sklerose-Läsionen: Immunhistochemische Analyse im Bezug auf immunopathogenetische Subtypen und Läsionsaktivitäten
(2012-06-21)Multiple sclerosis is a chronic inflammatory demyelinating disease of the CNS. The heterogeneity of the disease is reflected in different immunopathological patterns. Aim of the study is the examination of lymphocytes ... -
Medikamentöse Defibrinogenierung zur Behandlung des akuten Hörverlustes – eine verblindete, placebokontrollierte In-vivo-Studie
(2020-11-26)Sudden hearing loss is one of the most common inner-ear diseases. The underlying pathomechanism is still not fully understood and most often it remains idiopathic. One of its discussed causes is the disturbance of cochlear ... -
Quantitative Untersuchung der Oligodendrozytendichte im Kortex von Callithrix-jacchus Marmosetten mit Experimenteller Autoimmuner Enzephalomyelitis
(2013-11-01)Histopathological studies of Multiple sclerosis (MS) are usually limited by the fact that autopsy tissue is usually from patients in the chronic stage of the disease. Thus far there are only few results on the pathology ... -
Reaktive Astrozytenveränderungen in Multiple-Sklerose-Läsionen: Morphologische und immunhistochemische Analyse unter Berücksichtigung verschiedener Läsionsaktivitäten und immunpathologischer Subtypen
(2011-06-15)Multiple sclerosis (MS) is a heterogeneous disease characterized by demyelination, inflammation, axonal loss, and astrogliosis. However, the role of astrocytes in the pathogenesis of MS ... -
Die Rolle des Interleukin-6 bei der Wallerschen Degeneration
(2010-12-02)The role of interleukin-6 during the wallerian degeneration. We investigate Interleukin-6 Knockout-Mice as model for the role of Interleukin-6. We studied nerve transection model of 4- and ...