Browsing Human- und Zahnmedizin by Advisor "Brockmöller, Jürgen Prof. Dr."
Now showing items 1-19 of 19
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Auswirkungen von CYP2D6-, CYP2C9- und CYP2C19-Polymorphismen auf Pharmakokinetik und Wirkungen von Carvedilol
(2011-11-28)Aims: Carvedilol is a beta blocker of the 3rd generation. Still little known is the relation between dependence on the CYP2D6-polymorphism on carvedilol pharmakokinetics and carvedilol pharmacodynamics. Furthermore ... -
Bedeutung des Cytochrom-P450-2C9- und -3A5-Genpolymorphismus für Pharmakokinetik, Wirkungen und Nebenwirkungen von Delta-9-Tetrahydrocannabinol bei gesunden Probanden und Probandinnen
(2009-06-25)Context: Concerning the consumption of illegal drugs, cannabis (main ingredient Delta-9-THC) has been the most common substance for 30 years in Germany and Europe. Nowadays THC is a subject ... -
Bedeutung erblicher Faktoren für die Variabilität der Pharmakokinetik von Arzneimitteln im Vergleich zwischen oraler und intravenöser Dosierung anhand einer Zwillingsstudie
(2020-09-22)The main objective of this study was to investigate hereditary and non-hereditary differences in the activity of the OATP1B1 transporter and the CYP2C9 and CYP3A4 enzymes between oral and intravenous drug dosing. It was ... -
Bedeutung genetischer Polymorphismen im Beta-1-Adrenorezeptor für die Wirkungen von Metoprolol und Carvedilol
(2014-08-08)Beta blockers are some of the most-prescribed medications in modern medicine regarding cardiovascular diseases. Their main molecular target ist the beta-1-adrenoceptor, a seven transmembrane helical proteine, belonging to ... -
Bedeutung genetischer Polymorphismen im organischen Kationentransporter OCT1 für die Pharmakokinetik und Nebenwirkungen von Proguanil
(2019-01-22)Currently, only limited data exists regarding organic cation transporter OCT1 in the context of polymorphisms in drug transporters and their impact on pharmacokinetics of drugs in humans. In vitro experiments showed that ... -
Bedeutung genetischer Polymorphismen in den Genen des Transportproteins SLC6A14, des Leptinrezeptors, des Adiponektins und des Adiponektin-Rezeptors für das Risiko, unter Antipsychotikatherapie Übergewicht zu erleiden
(2012-02-22)In previous studies it was shown that atypical antipsychotic drugs have an important effect on the human energy metabolism. Some patients treated with those drugs suffer from obesity or ... -
Bedeutung genetischer Varianten für das Auftreten von Herzrhythmusstörungen bei Patienten mit intrakardialem Kardioverter-Defibrillator: Eine Pilotstudie zu kardiologisch relevanten Surrogatmarkern und Prädiktoren von Herzrhythmusstörungen
(2016-11-11)Sudden cardiac death (SCD) due to caradiac arrhythmias is a major complication in patients with cardiac disease. However risc stratification is improvable as life-threatening cardiac arrhythmias do not occur in many patients ... -
Biomarker für Oxidativen Stress bei Entzündungsreaktionen: Bedeutung von Genpolymorphismen und Genexpression der NADPH-Oxidase unter pro- und anti-inflammatorischen Bedingungen
(2013-10-18)Background NADPH oxidases (NOX) comprise a multimeric enzyme system expressed in various types of cells and tissues. The most popular isoform is that in leucocytes termed NOX2 according to the big catalytic subunit and ... -
Einfluss des Renin-Angiotensin-Systems auf die menschliche Erythropoetinproduktion unter normoxischen Bedingungen und nach Stimulation durch Fenoterol
(2010-11-08)Current evidence suggests that angiotensin II (AT II) is strongly involved as a key transmitter in the regulation of renal erythropoietin (EPO) production. In our study we found a significant ... -
Erblichkeit in der Aktivität der Enzyme CYP2D6 und CYP2C9 sowie des Transporters OATP1B1 unter Berücksichtigung der bereits bekannten genetischen Varianten
(2014-08-04)BACKGROUND AND OBJECTIVES: It is well accepted that variability in drug responses can be explained by multiple environmental and genetic factors. The individual drug response to the same dose can range from therapy failure ... -
Genomic variations in the EGFR pathway in relation to skin toxicity of EGFR inhibitors analyzed by deep sequencing
(2015-04-08)The development of targeted therapy has promised a new era in cancer therapy by improving response rates and fewer side effects of the therapeutics on normal cells. As the involvement of EGFR was noticed in several epithelial ... -
Grundlegende Untersuchungen zur erblichen Variation der Aktivitäten der Efflux-Transportproteine MDR1 und MRP2: Eine Zwillingsstudie mit Talinolol als In-vivo-Testsubstanz
(2016-03-23)BACKGROUND AND OBJECTIVES: The main objective of this study was to contribute to advancing personalized medicine, which means selecting the optimal drug in the optimal dose for each patient. For that it is necessary to ... -
Identifizierung genetischer Biomarker für die Wirksamkeit von Oxaliplatin:Kandidatengen-bezogene und Genom-weite Analysen
(2014-11-28)Oxaliplatin is an anticancer drug used to treat advanced and metastatic stages of colorectal carcinoma. In patients, different treatment responses can be observed suggesting an impact of germline genetic variability. ... -
Identifizierung von Biomarkern für die Prognose der Gemcitabin-Therapie beim Pankreaskarzinom: RNA-, DNA- und Immunhistochemische- Analysen
(2015-02-06)One aim of this study was to investigate the associations of genetic polymorphisms in the genes involved in gemcitabine pathways and the cinical outcome of patients with pancreatic ductal adenocarcinoma. A nucleoitide ... -
Molecular mechanisms of the TGFβ1 Arg25Pro polymorphism related to acute radiotherapy-induced toxicity
(2015-03-25)In radiochemotherapy administered for rectal cancer, all patients harboring the Pro25 allele in the signal peptide of TGFβ1 experienced a higher grade of acute treatment toxicity. Pro25 features an allelic frequency of ... -
Pharmakokinetik von Doxorubicin: Populationsvariabilität und Einfluss von genetischen Polymorphismen in Membran-Trasportproteinen
(2007-08-02)In this thesis, the impact of genetic polymorphisms of the membrane transporters MDR1, MRP1, MRP2, MRP3 and BCRP on the pharmacokinetics and side effects of doxorubicin of 94 non-pretreated ... -
Studie zu erblichen Einflüssen auf die Pharmakokinetik von Midazolam und Koffein
(2015-04-23)The individual effects of drug reaction is subject to large interindividual variations. Based on a better understanding of the causes of these variations and a customization of pharmacotherapies an improvement of the effects ... -
Therapeutisches Drug Monitoring von Immunsuppressiva: Vergleich intrazellulärer Konzentrationsmessungen mit Messungen in Vollblut
(2018-11-06)This doctoral thesis is optimization of therapeutic drug monitoring (TDM) after liver transplantation. After transplantation patients must receive continuous immunosuppression to prevent organ rejection. Besides glucocorticoids ... -
Variabilität des Therapieansprechens von Gemcitabin bei Pankreaskarzinom: Identifizierung relevanter Genpolymorphismen
(2013-01-23)Gene polymophisms could play an important role in the variability of therapy response in gemcitabine treated patients with pancreatic carcinoma. The retrospective study showed that a polymorphism in ENT-1, a carrier of ...