Browsing Human- und Zahnmedizin by Advisor "Zerr, Inga Prof. Dr."
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Neuronal-exosomes biomarkers from plasma of neurodegenerative disease patients
(2025-01-21)The dementia group of diseases share some features such as the degeneration of neurons, which leads to progressive and irreversible loss of cognitive functions. Since almost 10 years, dementia syndromes were declared a ... -
Untersuchung plasmabasierter Kompositbiomarker in der Differentialdiagnostik von Alzheimer-Demenz und Vaskulärer Demenz
(2025-01-17)Due to demographic change, dementia is not only at the center of medical research but is also becoming increasingly important in the health economic and social debate. Taking that into consideration, dementia diagnostics ... -
Vergleich klinischer und paraklinischer Charakteristika zwischen rapid progressiven und „klassischen“ Verlaufsformen der Alzheimer- Erkrankung
(2023-10-25)Alzheimer's disease is the most common neurodegenerative dementia, and its prevalence is expected to triple worldwide in the coming decades. The individual course of the disease in Alzheimer's dementia is very heterogeneous. ... -
Retrospektive epidemiologische Untersuchung des Zusammenhangs zwischen der Erkrankung mit sCJK und dem ärztlichen Beruf in Deutschland. Eine Studie mit Patientendaten von 1993 bis 2016.
(2022-11-04)The aim of the present study was to identify a possible risk factor for sporadic Creutzfeldt-Jakob disease (sCJD) through professional activity as a physician. For this purpose a retrospective cohort analysis was performed ... -
Gesamt-Tau, pTau, pTau rel, Beta-Amyloid 1-42 und 1-40 sowie Transthyretin in der Differentialdiagnostik neurodegenerativer Erkrankungen
(2022-11-01)New criteria have been published by the National Institute on Aging (NIA) and Alzheimer Association (AA) to define Alzheimer’s disease through the ATN classification system. The ATN classification system is based on ... -
Idiopathisches Parkinson Syndrom und a-Synuclein im Liquor: Bio- und Prognosemarker für Kognition, Krankheitsverlauf und depressive Symptomatik?
(2022-10-18)Bradykinesia, tremor and rigor are the main clinical features by which Parkinson’s Disease (PD) has been diagnosed clinically since the first describer, James Parkinson. A diagnosis-supporting biomarker does not exist yet. ... -
Heterogenität von Prionprotein-Isoformen im Liquor cerebrospinalis von Patienten mit verschiedenen Typen von Prionenerkrankungen: Eine Charakterisierung unter Betrachtung zwölf monoklonaler PrP-Antikörper
(2022-01-11)The cellular prion protein is a multifunctional, evolutionarily highly conserved and ubiquitously expressed protein. It goes through a number of modifications during its post-translational processing, resulting in various ... -
Analyse der Diagnosekriterien der Creutzfeldt-Jakob-Erkrankung in Deutschland
(2021-11-29)The Creutzfeldt-Jakob disease (CJD) is the most common prion disease. With an incident of 1.5 cases per 1,000,0000 inhabitants in Germany around 120 people (97% of all prion disease cases) are diagnosed with this disease ... -
Auswirkungen kardiovaskulärer Risikofaktoren sowie verschiedener Vor- und Begleiterkrankungen auf den Verlauf der Alzheimer-Demenz
(2021-06-22)Alzheimer’s disease is the most common form of dementias. Among patients with Alzheimer’s disease different rates of progression have been observed, not knowing which risk factors could lead to faster cognitive decline. ... -
Biomarker in der Diagnostik und Differentialdiagnostik der vaskulären Demenz bei zerebraler Mikroangiopathie
(2019-06-27)AIMS AND BAKCGROUND: Besides Alzheimer’s disease (AD), Vascular dementia (VD) caused by cerebral small vessel disease (CSVD) is one of the most common causes of dementia but differential diagnosis, especially the ... -
Immunologisches Profil und PrPC-Expression von Patienten mit subkortikaler vaskulärer Enzephalopathie und vaskulärem kognitivem Impairment
(2017-03-02)The impact of vascular cognitive impairment (VCI) in society is increasing. Subcortical vascular encephalopathy (SVE) is the most common cause of VCI and is manifested mainly by White Matter Lesions (WMLs) and clinical ... -
Die Prion-Protein-Isoformen
(2016-09-20)We performed two-dimensional immunoblotting of prion protein charge isomers of PrPC from human CSF of CJD patients with sporadic and familial CJD and control patients with distinct codon 129 polymorphism or different prion ... -
Charakterisierung von Prädiktoren rapid-progressiver Verläufe des M. Alzheimer
(2016-07-12)Alzheimer´s Disease (AD) is a neurodegenerative disorder, whose causes still have to be elucidated. The courses of the disease are heterogen, and rapid progresses were discribed. The data about risk factors and predictors ... -
Klinische und diagnostische Eigenschaften der sporadischen Creutzfeldt-Jakob-Krankheit bei Patienten mit positiver Familienanamnese für Demenz oder Morbus Parkinson
(2016-06-16)OBJECTIVE It was suggested that the cause of sporadic Creutzfeldt-Jakob disease (sCJD) is a spontaneous change in configuration of the prion protein. The acceptance of the influence of the misfolded protein chains which ... -
Steroid-responsive Enzephalopathie bei Autoimmunthyreoiditis als Differentialdiagnose der Creutzfeldt-Jakob-Krankheit
(2016-03-08)The SREAT is a rare, progressive multiform disease that is not well understood. It is characterized by wide unspecific neuropsychiatric symptoms, elevated thyroid antibodies, and the good response to immunosuppressive ... -
Liquormarker in der Diagnostik bei Patienten mit Morbus Parkinson, Parkinson-Demenz-Komplex und Morbus Alzheimer
(2015-09-24)Suffering from dementia, such as Alzheimer’s disease ("AD") and Parkinson’s disease with dementia ("PDD"), has far-reaching consequences for the patient’s self-determined life. In contrast to Alzheimer’s disease, there’s ... -
Prognostische Aussagekraft von White Matter Lesions auf den kognitiven Verlauf bei Patienten mit zerebraler Mikroangiopathie
(2014-11-03)White matter lesions (WML) of the brain are a frequent finding in magnetic resonance imaging (MRI) and their significance remains a controversy. The aim of the study was to identify prognostic value of WML and other risk ... -
Magnetresonanztomographie bei Patienten mit der E200K- und V210I-Mutation
(2014-10-10)Prion diseases are a group of rare infectious neurodegenerative disorders, which are caused by aggregation of the misfolded pathological prion protein. Three subtypes can be distinguished according to their etiology: ... -
Liquormarker Aß 1-42, T-Tau und P-Tau in der Differenzialdiagnostik der Demenzen
(2014-07-14)A correct diagnosis is not always easy to obtain in case of neuro degenerative diseases. Besides clinical appearance and neuro imaging especially the analysis of the cerebrospinal fluid (CSF) is helpful if results are ... -
Über die Interaktionen des zellulären Prion-Proteins (PrPc) mit relevanten Proteinen der Alzheimer Erkrankung
(2014-07-08)Previous studies indicate an important role for the cellular prion Protein (PrPc) in the development of Alzheimer's disease pathology. In the present study the interaction of PrPc with Alzheimer relevant proteins such as ...