Browsing Human- und Zahnmedizin by Referee "Dobbelstein, Matthias Prof. Dr."
Now showing items 1-20 of 25
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Evaluation of desmoplastic and replacement type histopathological growth patterns of colorectal cancer liver metastases at single-cell resolution
(2024-09-10)This thesis project evaluated molecular differences between desmoplastic and replacement colorectal liver metastases, with the focus on the heterogeneity between ECs in livers colonized by CRCLM. Stratifying the sample ... -
Das Onkoprotein Mdm4 und seine Wirkung auf die DNA-Replikation
(2024-08-05)The oncoprotein MDM4, together with its family member MDM2, is one of the most important regulators of the tumor suppressor p53. This study demonstrates that loss of MDM4 in p53-deficient cells significantly compromises ... -
Die Rolle von ARID1A in Pankreas- und kolorektalem Karzinom
(2023-05-23)Overall, ARID1A showed a strongly context-dependent function in this study (Sun et al. 2017). In particular, in pancreatic tumors, the tumor suppressive function of ARID1A could be partially confirmed in terms of growth ... -
Analysis of Expression of RNA Helicases and Cofactors in Human Tissues and Cancer
(2023-05-11)RNA helicases are ubiquitously expressed enzymes that function as key regulators of many different aspects of gene expression. They use their nucleoside triphosphate-dependent activity to drive the remodeling of various ... -
Expressionsmuster von EBV mikroRNAs in Hodgkin Lymphomen
(2023-03-24)Epstein-Barr virus encodes 40 different miRNAs with considerable impact on cellular functions of the latently infected cell. In this study EBV miRNA expression patterns in EBV-positive Hodgkin lymphoma and other malignant ... -
In-vitro- und In-vivo-Untersuchungen zum Gemcitabinmetabolismus von Makrophagen im Duktalen Adenokarzinom des Pankreas
(2022-09-26)Despite great scientific and clinical efforts, pancreatic cancer still has a fatal prognosis. In addition to the usually late diagnosis, this is mainly due to the tumour's resistance to chemotherapy. Gemcitabine and ... -
Cancer cell death by mitotic failure upon combined kinase inhibition
(2022-06-02)Cancer cells are prone to replicative stress to a greater extent than healthy cells are. Thus, replicative stress might be a way to target cancer cells in a more specific way than conventional chemotherapeutics do. According ... -
Funktionen von Trp53 in der Homöostase des Bronchialepithels und der Kontrolle pulmonaler Entzündungsreaktionen als modellhafte Perspektive auf die COPD
(2021-11-02)The pulmonary epithelia of patients with COPD show an increased expression of TP53 and have higher proliferation and apoptosis rates, compared to healthy individuals. Although, Trp53-deficient mouse lung have higher ... -
Der Tumorsuppressor p53 reguliert HSF1 im Modell des kolorektalen Karzinoms
(2021-07-13)The regulator of the cellular stress response programm HSF1 is regulated by the tumor suppressor p53 by inhibition of the phosphorylation of Ser326. This reduces HSF1 transcriptional activity and halts the stress response ... -
Investigation of genetic and translational effects of tumor suppressor proteins in two hereditary forms of renal cell carcinoma
(2021-05-07)Some familial cancer syndromes are known to cause renal cell carcinoma (RCC) in afflicted subjects. I studied the role of tumor suppressor genes in two syndromes: Birt-Hogg-Dubé (BHD) and von Hippel-Lindau (VHL). BHD is ... -
The DNA damage kinases MK2, Chk1 and the chromatin remodeling factor CHD8 determine the cellular outcome after replicative stress and DNA damage
(2021-03-26)DNA damage occurs and accumulates in every cell and is cause and consequence of cancerogenesis. Massive induction of exogenous DNA damage has its use in chemotherapy as it causes growth arrest and apoptosis in malignant ... -
Die Rolle des Tumorsuppressors p53 in der ungestörten S-Phase
(2020-12-11)The tumor suppressor protein p53 and its functional network are one of the most important means of an organism to protect a cell from the adverse effects of genotoxic stress and to prevent its malignant degeneration. Due ... -
Differential responses of human melanoma cells to c-Rel downregulation
(2020-01-29)The transcription factor NF-κB, which is one of the central regulators regarding cell growth, proliferation, apoptosis, inflammation and invasion, was shown to also play a role in melanoma development and progression. ... -
Die Rolle von CBP bei der Strahlenresistenzentwicklung im kolorektalen Karzinom
(2019-07-22)This thesis focuses on the protein CBP (CREB-binding protein) in colorectal cancer. CBP is a histone acetyltransferase with 4 transactivation domains and acetylates a wide variety of proteins. CBP is a multifunctional ... -
Accumulation of single-stranded DNA in tumour cells as a result of replicative stress
(2018-01-15)Cells are constantly subjected to DNA damaging agents like reactive oxygen species, UV light or, in the case of cancer cells, chemotherapeutic drugs. All these agents can lead to replicative stress, meaning that the most ... -
HDAC inhibitor valproic acid increases CRABP2 expression and in combination with retinoic acid synergistically inhibits proliferation in glioblastoma cells
(2016-12-12)Background: Although integrated treatments were implemented, glioblastoma multiforme (GBM) remains one of the most lethal primary brain tumors. The cellular retinoic acid–binding protein 2 (CRABP2) plays a crucial role, ... -
Relevanz des Wnt/β-Catenin-Signalwegs für die Radiotherapieresistenz des kolorektalen Karzinoms
(2016-07-11)The clinical response of rectal carcinomas to preoperative radiotherapy is highly heterogeneous, ranging from complete remission to total resistance. Unfortunately, patients with a resistant tumour are challenged with a ... -
Die Interaktion von ErbB2/Her2 mit Hitzeschockproteinen in Mammakarzinomzellen
(2015-01-19)Overexpression of the human epidermal growth factor receptor-2 (HER2) in breast cancer strongly correlates with aggressive tumors and poor prognosis. Recently, a positive correlation between HER2 and MIF (macrophage migration ... -
Prädiktive und prognostische Relevanz von p53 und Ki67 beim lokal fortgeschrittenen Rektumkarzinom cUICC-II/III
(2013-10-21)In Germany, colorectal carcinoma represents the second most common cause of death in cancer diseases. The treatment of rectal cancer is stage-dependent and includes a multimodal therapy concept. Currently, the therapeutic ... -
The Necessity of Geminin for Pluripotency and Neural Lineage
(2013-08-21)Pluripotent mouse embryonic stem cells (ESCs) are in vitro derivatives of the early mouse embryo. They can self-renew infinitely, and have the ability to differentiate into embryonic lineages including the germ line. ESCs ...