Browsing Human- und Zahnmedizin by Referee "Hanisch, Uwe-Karsten Prof. Dr."
Now showing items 1-10 of 10
-
B Cell Antigen Receptor-intrinsic Costimulation of IgG and IgE Isotypes
(2012-06-27)B cells express different isotypes of the B cell antigen receptor (BCR) on their surface and secrete soluble forms of their antigen binding immunoglobulins (Ig) upon differentiation to plasma cells. Naïve mature B cells ... -
Effects of Wnt and different TLR stimulations on microglia-induced invasion of breast cancer cells
(2012-10-31)The role of the benign microenvironment in the primary tumor has recently come into focus. In particular, research has shown that blood-derived macrophages may support tumor progression. By contrast, the role of resident ... -
Etablierung und Validierung der RNA-Interferenzmethode am Beispiel Apoptose-relevanter Gene
(2012-07-05)Specific inhibition of gene expression is becoming an increasingly important method for experimental strategies to influence tumor growth on a molecular level. In this work, we investigated the role of individual molecules ... -
Liposomal verkapselte Glukokortikosteroide in der Therapie der mdx-Maus als Modell der Duchenneschen Muskeldystrophie
(2010-09-20)Treatment of Duchenne Muscular Dystrophy (DMD) with glucocorticosteroids (GS) improves patients strength, but is limited by unwanted side effects. Liposomal encapsulation enhances half ... -
Lokale Stimulation des pulmonalen Immunsystems mit dem TLR2/6-Agonisten MALP-2 und deren Auswirkung auf pulmonale Melanommetastasierung im Maus-Modell
(2014-07-04)Metastasized melanoma is still a non-curable often lethal disease. More than 50% of patients with metastasized melanoma develop lung metastases. The mean survival time after formation of pulmonary metastases is only 7.3 ... -
Regulation der mRNA von Toll-Like-Rezeptoren bei experimentellen ZNS-Infektionen
(2012-11-20)Regulation of the mRNA of toll-like receptors in experimental CNS infections Toll-like receptors are sensors and regulators of innate immunity. We investigated the expression of TLRs in experimental infections with ... -
Role of amyloid beta protein modulation in Alzheimer's disease
(2012-07-17)Alzheimer's disease (AD) is the most common neurodegenerative disease in the elderly. It is mainly characterized by the deposition of amyloid plaques and neurofibrillary tangles. In addition, inflammatory processes in ... -
Die Rolle der residenten monozytären Zellen sowie Tumorzell-spezifischer Faktoren bei der Metastasierung des Mammakarzinoms
(2013-09-05)Metastasis is the leading cause of cancer death and marks the turning point of cancer diseases where cure is rarely possible. Searching for new therapy approaches to prevent metastasis, an important finding was the ... -
Selective transfer of exosomes from oligodendrocytes to microglia by macropinocytosis
(2011-01-27)Oligodendrocytes are the myelin forming cells of the central nervous system. These cells synthesize vast amounts of membrane during the active phase of myelination. In addition, membrane ... -
Untersuchung der Schwann-Zell-Migarion und -Proliferation im peripheren sympathischen Nervensystem der Maus
(2011-10-27)Schwann cells are glial cells of the peripheral nervous system which are responsible for the myelination of nerve axons taking on a nutrimental function at the same time. The expansion of ...