Browsing Human- und Zahnmedizin by Referee "Johnsen, Steven Prof. Dr."
Now showing items 1-15 of 15
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Die Rolle von ARID1A in Pankreas- und kolorektalem Karzinom
(2023-05-23)Overall, ARID1A showed a strongly context-dependent function in this study (Sun et al. 2017). In particular, in pancreatic tumors, the tumor suppressive function of ARID1A could be partially confirmed in terms of growth ... -
Anreicherung und semiautomatisierte Detektion HER2-positiver zirkulierender Tumorzellen im Mammakarzinom
(2023-03-09)In clinical practice HER2 status has so far been determined using tissue samples from biopsies. As sample collection is an invasive, time-consuming procedure for patients, the focus is nowadays on blood-based biomarkers ... -
Die Rolle des Chromatinmodulators CHD1 im kastrationsresistenten Prostatakarzinom
(2021-09-02)Current therapy of metastasized prostate cancer largely depends on androgen-deprivation therapy (ADT). Despite initial response, tumors inevitably reach castration resistance (CRPC), a stage at which chemotherapy and ... -
Einfluss von RhoA auf die Invasivität von Mammakarzinomzellen
(2021-05-20)Breast cancer is the most frequent cancer women suffer from. The most common cause of death is metastasis not the tumor itself, in this stage the disease is no longer curable. This underlines the great significance of ... -
Comprehensive analysis of transcription factor activity monitoring with Cis-elements coupled EXTassys in living cells
(2018-07-04)The vast development in computational science enabled a revolutionary process in the whole –OMICS field (e.g. genomics, transcriptomics, proteomics etc.). Automated equipment allows an upscaling of experiments without ... -
Verstärkung der Antitumorwirkung von Estrogenantagonisten durch die Kombination mit einem GnRH-II-Antagonisten, angewandt an Zelllinien des Ovarialkarzinoms
(2016-07-14)Over the last years GnRH-II-antagonists have presented a focus of interest in the endocrine therapy of gynecological and other cancers such as prostate cancer. It was shown that GnRH-II-antagonists even in nanomolar ... -
‘Knockout-first’ mouse model as a biological tool to study the role of KIAA0182 gene in hypoplastic left heart syndrome
(2016-03-08)Objective: Hypoplastic left heart syndrome (HLHS) is one of the most severe congenital heart diseases. The genetic etiology for this syndrome was strongly suggested by several previous studies, and a lot of genes were ... -
Die Wirkung von GnRH-Analoga auf die Expression von Wachstumsfaktoren und deren Rezeptoren in humanen Mammakarzinomzellen und der Osteoblasten-ähnlichen Zellreihe MG-63 während der Kokultur
(2016-01-13)Breast cancer is the most common cancer of women worldwide. In the advanced stage of the disease, up to 75% of all patients develop bone metastases. Based on the finding that GnRH analogues inhibit the migration and ... -
Functional Assessment of Biomarkers in Gemcitabine-Treated Pancreatic Cancer with Specific Focus on Nucleoside Transporter ENT1
(2013-10-31)Pancreatic ductal adenocarcinomas are the fourth leading cause of death among all kinds of cancers. The poor prognosis is due to usually late diagnosis and, in most cases, the available therapeutic options lack sustained ... -
Characterization of Interleukin 10 gene variations and serum levels as predictive factors for the clinical outcome of Non-Hodgkin Lymphoma patients and Analysis of molecular mechanisms of Interleukin 10 gene regulation in B cells
(2013-03-06)Aggressive Non-Hodgkin lymphoma (aNHL) comprises a heterogeneous group of lymphatic malignancies. Although current treatment regiments can achieve high response rates, many patients do not achieve complete remission. ... -
B Cell Antigen Receptor-intrinsic Costimulation of IgG and IgE Isotypes
(2012-06-27)B cells express different isotypes of the B cell antigen receptor (BCR) on their surface and secrete soluble forms of their antigen binding immunoglobulins (Ig) upon differentiation to plasma cells. Naïve mature B cells ... -
Die Funktionsanalyse und Pharmakomodulation des Amyloid-Vorläufer-Proteins (APP) in vitro und in vivo - Eine neue Zielstruktur zur Behandlung maligner Tumore
(2012-02-28)The ß-amyloid precursor protein (APP) represents a type I transmembrane glycoprotein that is ubiquitously expressed in neuronal as well as in non-neuronal cells. In brain it is a key player ... -
Investigation of TRAIL resistance in ovarian cancer cell lines and translational application in primary ovarian cancer cells
(2011-09-21)Ovarian cancer, the deadliest of the gynaecologic malignancies, poses a therapeutic challenge because of the 70% recurrence rate among patients treated with taxane/platinum-based chemotherapy. ... -
Interaktionen von humanen mesenchymalen Stromazellen (hMSC) mit Plattenepithelkarzinomzellen des Oropharynx in indirekter Kokultur
(2011-05-16)Head and neck squamous cell cancer (HNSCC) is the most frequent malignant tumor of the oropharyngeal region. Population-based cancer statistics show only little evidence of improvement in ... -
Expression und Funktion des Vitamin-D-Rezeptors in malignen Keimzelltumoren des Hodens
(2011-02-25)Testicular germ cell tumours (TGCT) are the most common malignancy in young men. They are clinical and histological subdivided in seminomas and non-seminomas. 1,25-dihydroxyvitamin D3 ...