Dokumente Human- und Zahnmedizin nach Gutachter "Kramm, Christof Prof. Dr."
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Einfluss der Expression von Signaltransduktion-, Stammzell- und Zellzyklus-assoziierten Genen auf das Gesamtüberleben von pädiatrischen Glioblastompatienten
(2023-07-31)The Glioblastoma multiforme, as a highly malignant brain tumor, is associated with a very unfavorable prognosis. The median survival time after diagnosis is reported to be nine months to two years, with a 5-year survival ... -
Funktionelle Analysen zu Erkrankungen, die zu einer Dysfunktion/Fehlregulation ribosomaler Proteine führen
(2023-01-20)Ribosomopathies are characterized by impaired synthesis or function of ribosomes. Mutations in genes which code for components of the normal ribosomal biogenesis lead to these rare congenital diseases. Functional analyses ... -
Untersuchung der therapeutischen Wirkmechanismen von Kurkumin in diffus intrinsischen Ponsgliomen in Abhängigkeit vom Mutationsstatus im H3F3A-Histongen (H3.3K27M-Mutation)
(2022-10-17)Diffuse intrinsic pontine glioma (DIPG) are pediatric high grade glioma localized in the brainstem and associated with a fatal prognosis. 85% of all DIPG carry a H3K27M mutation, which leads to epigenetic dysregulation ... -
Medulloblastome im Kindes- und Jugendalter im Zeitraum von 1989 bis 2015
(2022-02-22)Medulloblastoma is the most common malignant brain tumor in children and adolescents and its therapy is still difficult due to the vulnerability of the child's brain. Medulloblastomas arise in the posterior fossa of the ... -
A combination of repurposed drugs reduces the proliferation and viability of glioblastoma cells
(2021-10-01)Background: Glioblastoma multiforme (GBM) is a malignant primary brain tumour with high rates of recurrence. The tumour is characterized by high molecular diversity. A strategy to simultaneously target different oncogenic ... -
Epidemiologische und klinische Charakterisierung von Langzeitüberlebenden mit hochgradigem Gliom im Kindes- und Jugendalter
(2021-08-30)Pediatric high-grade gliomas account for 8-12% of primary tumors in the central nervous system during childhood. Currently, the prognosis is still dismal. Only about 10% of patients achieve long-term survival. Therefore, ... -
Therapieeffizienz und -sicherheit der simultanen Radiochemotherapie bei hochgradigen Gliomen des Kindesalters: Vergleich zwischen Temozolomid- und Cisplatin-basierten Chemotherapieregimes
(2021-07-27)A retrospective data analysis of a total of 575 children and adolescents from the HIT-GBM-C / D study and the HIT-HGG 2007 study with highly malignant gliomas was carried out. The two simultaneous chemotherapy regimen were ... -
Kriterien für die frühe Integration von Palliativmedizin in der Pädiatrie
(2021-06-10)Early integration of palliative care in paediatrics The aim of the present study was to determine criteria for the (early) integration of palliative care in paediatrics from the perspective of paediatricians in both private ... -
Extendierte adjuvante Chemotherapie mit Temozolomid in der Behandlung maligner Gliome - Eine retrospektive Datenanalyse zur Wirksamkeit und Hämatotoxizität im klinischen Alltag
(2018-09-03)To receive a control over the efficiency as well as the compatibility of an extended temozolomide therapy, a retrospective analysis of data has been conducted in the context of this research. The data has been obtained out ... -
Etablierung und Charakterisierung eines experimentellen Modells für invasive Gliome
(2018-04-04)Gliomas belong to the most malignant cancers we know. It is accepted that origin of the disease and glioma progression is caused by glioma-initiating cells (GICs). These cells have stem-cell attributes and are thought to ... -
Identification of Prognostically Relevant Cellular Markers of Differentiation in Glioblastoma
(2016-09-28)Introduction: Glioblastoma multiforme is the most common primary brain tumor. Despite intense research efforts worldwide, the prognosis of patients diagnosed with this tumor remains poor. Several clinical and molecular ... -
Immunhistologische Charakterisierung maligner Veränderungen beim Glioblastoma multiforme
(2014-12-04)This study presents the results of paraffin sections from human brain tumors that have been coloured by means of immunohistological staining. Different kinds of glial tumors were investigated: Astrocyte WHO °II, astrocyte ... -
Überprüfung eines Serumproteinprofils für die Diagnostik von Glioblastomen
(2013-11-07)The diagnosis of glioblastoma (GBM ) is currently supported by diagnostic imaging and histological examination in addition to clinical symptoms. In the past years, an increasing number of serum proteins, which are associated ...