Browsing Human- und Zahnmedizin by Referee "Kramm, Christof Prof. Dr."

Seltene pädiatrische nicht-diffuse hochgradige Gliome: Epidemiologische und klinische Charakterisierung von anaplastischen Gangliogliomen, anaplastischen pleomorphen Xanthoastrozytomen und pilozytischen Astrozytomen mit Anaplasie

Baldini, Christian (2025-11-18)

Pediatric high-grade gliomas (pHGG) are rare and aggressive central nervous system tumors in children and adolescents. Non-diffuse subtypes such as anaplastic ganglioglioma, anaplastic pleomorphic xanthoastrocytoma, and ...

In vitro testing of histone deacetylase inhibitors (HDACi) in combination with temozolomide radio-chemotherapy as a treatment strategy for pediatric high-grade gliomas (pedHGG)

George, Sophie Therese (2025-11-03)

Pediatric high-grade gliomas (pedHGG) are highly malignant pediatric brain tumors associated with a fatal prognosis and include, among others, diffuse intrinsic pontine gliomas (DIPG), which in 65 % carry an H3.3K27M ...

Die Rolle der Hedgehog Signalkaskade in Ependymomen

Nitzki, Frauke Saskia (2025-03-12)

In this thesis the activity of Hedgehog (HH) signaling in ependymoma was analyzed. To this end, immunohistochemical stainings were performed on 86 paraffin sections to examine the expression of Sonic Hedgehog (SHH). The ...

Überlebensanalysen von Patienten mit Glioblastomen – Identifikation von klinischen, radiologischen und molekulargenetischen prognostischen Faktoren

Conrad, Katharina (2024-11-12)

Obtaining a prognostic assessment at the time of diagnosis is of great importance for the affected patients and their relatives. Clinical, radiological and molecular genetic factors were examined as predictive parameters ...

Vergleich klinischer und epidemiologischer Parameter der primären Gliomatosis cerebri und primär multifokaler hochgradiger Gliome im Kindes- und Jugendalter

Tacke, Anna (2024-08-26)

To date no differentiation is being made between varying growth phenotypes of pediatric high-grade gliomas (pHGG). This thesis compares primary pediatric Gliomatosis cerebri (GC) and primary multifocal/multicentric (PMF) ...

Konsolidierung oder aktive Tumorverkleinerung: Therapeutische Effizienz einer Erhaltungschemotherapie bei hochgradigen Gliomen des Kindes- und Jugendalters

Freude, Mascha Tabea (2024-07-02)

High-grade gliomas of childhood and adolescence (pHGG) constitute a heterogenous group of malignant primary tumours of the central nervous system. The prognosis for the majority of pHGG is poor, with only a few therapeutic ...

Einfluss der Expression von Signaltransduktion-, Stammzell- und Zellzyklus-assoziierten Genen auf das Gesamtüberleben von pädiatrischen Glioblastompatienten

Schill, Fabian Tassilo (2023-07-31)

The Glioblastoma multiforme, as a highly malignant brain tumor, is associated with a very unfavorable prognosis. The median survival time after diagnosis is reported to be nine months to two years, with a 5-year survival ...

Funktionelle Analysen zu Erkrankungen, die zu einer Dysfunktion/Fehlregulation ribosomaler Proteine führen

Noceti, Miriam D. (2023-01-20)

Ribosomopathies are characterized by impaired synthesis or function of ribosomes. Mutations in genes which code for components of the normal ribosomal biogenesis lead to these rare congenital diseases. Functional analyses ...

Untersuchung der therapeutischen Wirkmechanismen von Kurkumin in diffus intrinsischen Ponsgliomen in Abhängigkeit vom Mutationsstatus im H3F3A-Histongen (H3.3K27M-Mutation)

Zastrow, Johanna (2022-10-17)

Diffuse intrinsic pontine glioma (DIPG) are pediatric high grade glioma localized in the brainstem and associated with a fatal prognosis. 85% of all DIPG carry a H3K27M mutation, which leads to epigenetic dysregulation ...

Medulloblastome im Kindes- und Jugendalter im Zeitraum von 1989 bis 2015

Diouf, Sarah Maimouna (2022-02-22)

Medulloblastoma is the most common malignant brain tumor in children and adolescents and its therapy is still difficult due to the vulnerability of the child's brain. Medulloblastomas arise in the posterior fossa of the ...

A combination of repurposed drugs reduces the proliferation and viability of glioblastoma cells

Sachkova, Aleksandra (2021-10-01)

Background: Glioblastoma multiforme (GBM) is a malignant primary brain tumour with high rates of recurrence. The tumour is characterized by high molecular diversity. A strategy to simultaneously target different oncogenic ...

Epidemiologische und klinische Charakterisierung von Langzeitüberlebenden mit hochgradigem Gliom im Kindes- und Jugendalter

Hunger, Antonia Gisela (2021-08-30)

Pediatric high-grade gliomas account for 8-12% of primary tumors in the central nervous system during childhood. Currently, the prognosis is still dismal. Only about 10% of patients achieve long-term survival. Therefore, ...

Therapieeffizienz und -sicherheit der simultanen Radiochemotherapie bei hochgradigen Gliomen des Kindesalters: Vergleich zwischen Temozolomid- und Cisplatin-basierten Chemotherapieregimes

Schreiner, Sabrina (2021-07-27)

A retrospective data analysis of a total of 575 children and adolescents from the HIT-GBM-C / D study and the HIT-HGG 2007 study with highly malignant gliomas was carried out. The two simultaneous chemotherapy regimen were ...

Kriterien für die frühe Integration von Palliativmedizin in der Pädiatrie

Steging, Inga (2021-06-10)

Early integration of palliative care in paediatrics The aim of the present study was to determine criteria for the (early) integration of palliative care in paediatrics from the perspective of paediatricians in both private ...

Extendierte adjuvante Chemotherapie mit Temozolomid in der Behandlung maligner Gliome - Eine retrospektive Datenanalyse zur Wirksamkeit und Hämatotoxizität im klinischen Alltag

Karges, Julia (2018-09-03)

To receive a control over the efficiency as well as the compatibility of an extended temozolomide therapy, a retrospective analysis of data has been conducted in the context of this research. The data has been obtained out ...