Browsing Human- und Zahnmedizin by Referee "Liersch, Torsten Prof. Dr."
Now showing items 1-14 of 14
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Totale neoadjuvante Therapie des Rektumkarzinoms – Sicherheit, Durchführbarkeit und Wirksamkeit – (Langzeit-) Ergebnisse eines monozentrischen Patientenkollektivs
(2024-08-16)The aim of the present thesis was to evaluate safety, feasibility and efficacy of a total neoadjuvant therapy (TNT) for patients with locally advanced rectal cancer (LARC; cUICC stages II - IV; mid and lower rectum; lower ... -
Kardiovaskuläre Einflussfaktoren auf die gesundheitsbezogene Lebensqualität von onkologischen Patienten
(2024-02-29)Aims Five percent of the German population is living with the diagnosis of a malignant disease, which transforms – due to higher survival rates – to a chronic disease. Maintaining quality of life (QoL) has become increasingly ... -
Chirurgische Therapie des (lokal) fortgeschrittenen Adenokarzinoms im oberen Rektum – erste Ergebnisse aus der multizentrischen GAST-05-Phase IIb-Studie
(2023-08-01)The prospective, randomized, multicenter GAST-05 phase-IIb study (ISRCTN 35198481), funded by the German research Foundation, was designed to clarify whether partial mesorectal excision (PME, with a distal cancer-free ... -
Chirurgie des Rektumkarzinoms - Peri- und postoperative Qualitätskontrolle mit Beurteilung klinikopathologischer Risikofaktoren nach präoperativer Multimodaltherapie vs. primärer OP in IIT-Studien
(2023-06-27)Purpose: To evaluate diverse clinicopathological risk factors and peri-/postoperative quality control in specimens after total (TME) or partial (PME) mesorectal excision in patients with locally advanced rectal cancer ... -
Stellenwert der postoperativen FOLFOX-CTx beim primär operierten pUICC-II/-III-Karzinom des oberen Rektums – erste Ergebnisse aus der GAST-05-Studie
(2022-09-14)Summary
This inaugural dissertation is a contribution to the ongoing debate about optimal surgery (TME vs. PME) and adjuvant therapy (± 5-FU vs FOLFOX CTx) for patients with locally advanced adenocarcinomas (LARC, ... -
Staging-Prozeduren (MRT, CT und rES) beim lokal fortgeschrittenen Adenokarzinom des oberen Rektums (≥ 12 cm ab ACL) - erste Ergebnisse aus der GAST-05-Phase-IIb-Studie
(2022-05-30)Pelvic magnetic resonance imaging (MRI) has become well established in the staging of advanced adenocarcinomas of the rectum (stages ≥ UICC-II; aboral tumor margin < 12 cm from ACL) alongside rectal endosonography (rES) ... -
Chirurgisch-onkologische Ergebnisse bei fortgeschrittenen Adenokarzinomen (cUICC-II/-III) des Rektums
(2022-05-18)Preoperative 5-fluorouracil (5-FU)-based chemoradiotherapy (CRT +/- oxaliplatin; OX) for locally advanced adenocarcinoma of the rectum (LARC; clinically staged as stages II and III) is expected to improve resectability, ... -
Molekular-genetische Prädiktoren der Toxizität einer neo-adjuvanten Radiochemotherapie am Beispiel des Rektumkarzinoms
(2019-02-22)In Germany, around 20,000 people per year are diagnosed with rectal cancer. Neoadjuvant radiochemotherapy (N-RCT) has been established for routine treatment of cancers located in the lower and middle third of the rectum. ... -
Immunhistochemische Analyse der p16-Expression im Rektumkarzinom: Vergleich von Patienten mit und ohne neoadjuvante Radiochemotherapie
(2018-05-29)Background: In Germany the standard treatment of locally advanced adenocarcinoma within the first 12cm of the rectum is a neoadjuvant radiochemotherapy (RCT) followed by a total mesorectal excision (TME) and adjuvant ... -
Expression des epidermalen Wachstumsfaktorrezeptors Her2/neu in Rektumkarzinomen des lokal fortgeschrittenen Stadiums UICC II / III - Validierung an Patienten der Phase-III-Studien der German Rectal Cancer Study Group
(2016-08-22)Validation of the frequency of the expression of her2/neu in rectal cancer. Her2/neu is an epidermal growth factor receptor known from breast or oesophagus cancer and thought to be a possible therapy target in rectal cancer. -
Die Expression von SRC vor und nach neoadjuvanter Radiochemotherapie im lokal fortgeschrittenen Rektumkarzinom cUICC II/III.
(2016-01-12)Purpose: SRC, one of the oldest proto-oncogenes, is encoding for the tyrosine kinase of the same name. The protein, which is localized in the cytosol as well as in the cell membrane, is involved in cell proliferation and ... -
5-Fluorouracil-Spiegelbestimmung unter neoadjuvanter Radiochemotherapie und adjuvanter Chemotherapie beim lokal fortgeschrittenen Rektumkarzinom
(2015-05-06)5-fluoruracil (5-FU) still remains the backbone of chemotherapy in colorectal cancer and effects as a radiosensitizer for radiotherapy. During the last decades several clinical trials have demonstrated that neoadjuvant ... -
Untersuchung der Effektivität konduktiver versus konvektiver Wärmung von Patienten zur Vermeidung intraoperativer Hypothermie während radikaler Prostatektomie
(2014-11-10)Intraoperative hypothermia during radical prostatectomy – the efficacy of conductive versus convective patient warming Design: Prospective randomized effectiveness trial Background: In the prevention of perioperative ... -
ERCC1-Expression unter 5-FU- und Oxaliplatin-basierter multimodaler Therapie beim Rektumkarzinom (cUICC-Stadien II und III) - Potentielle prädiktive und prognostische Bedeutung
(2014-05-19)Purpose:The application of neoadjuvant radiochemotherapy (RCT) improves local control of patients with advanced rectal cancer. Current clinical trials focus on therapy intensification (e.g. using oxaliplatin) and the ...