Browsing Human- und Zahnmedizin by Referee "Mihm, Sabine Prof. Dr."
Now showing items 1-17 of 17
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Genetische Polymorphismen im Bereich der Interferon Lambda (IFNL)-Gene und deren prädiktiver Wert für ein Ansprechen auf eine Chemo- oder Radiotherapie bei onkologischen Patienten
(2024-11-29)Chemotherapy and radiotherapy are among the pillars of conventional cancer treatment. The toxic effects of chemotherapeutic agents and the ionizing effects of radiotherapy induce necrosis in neoplastic cells, leading to ... -
Rnaset2-Defizienz: Eine klinisch-experimentelle Betrachtung im Kontext der Typ-1-Interferonopathien
(2024-11-28)Rnaset2-deficient cystic leukoencephalopathy is a rare congenital disorder caused by a biallelic loss-of-function mutation. This dissertation consists of a clinical and an experimental part on this disease. Clinically, ... -
The Effects of Conventional Chemotherapeutics on the Activation of Type I Interferons (IFN-α/β) in Hepatic Cancer Cells in vitro: The Significance of Endogenous Type III Interferons (IFN-λ)
(2023-04-24)HCC is characterized by limited therapy options, poor response rates to systemic chemotherapy, and high lethality. Preclinical cancer models have revealed the efficacy of genotoxic drugs to rely on the release of type I ... -
Einfluss von Inhibitoren des PI3K/Akt/mTOR-Signalwegs auf die Makrophagen-/ Mikroglia-assistierte Invasion von Mammakarzinomzellen
(2022-10-10)The prognosis of patients affected by locally advanced or metastatic cancer is often drastically reduced due to a lack of effective treatment options, and the remaining lifespan is hence significantly limited. For this ... -
Genetische Polymorphismen in Typ-III-Interferon-Genen und deren prognostische Signifikanz für das hepatozelluläre Karzinom und das duktale Pankreasadenokarzinom
(2021-03-08)Hepatocellular carcinoma (HCC) and pancreatic ductal adenocarcinoma (PDAC) are malignancies with a leading lethality. With reference to interferons (IFNs) known to mediate antitumor activities, this study investigated the ... -
Einfluss der medikamentösen Präkonditionierung auf den Ischämie-/Reperfusionsschaden nach orthotoper Lebertransplantation im Rattenmodell
(2018-11-20)Due to the high discrepancy between supply and demand of organ donations, there is a major organ shortage. There are different ways in which to recover organs, especially those which are marginal. These particular organs ... -
Das metabolische Syndrom: die Auswirkung von β-Ecdyson auf ausgewählte Körperparameter und Serumlipide des metabolischen Syndroms
(2018-11-01)The aim of the study was to analyze the interactions between body fat, especially visceral fat depot, on parameters such as hsCRP and the lipid profile. The effects of ecdysone on the body parameters fat percentage, muscle ... -
Eine Analyse zur Expression detoxifizierender und cytoprotektiver Proteine in der durch Thioacetamid geschädigten Leber der Ratte
(2017-11-01)The understanding of underlying molecular and cellular mechanisms during development of an intrahepatic cholangiocarcinoma (iCC) is far from being complete. Connections of various mutations (APC, DCC, OGG1, p53, k-ras, ... -
Bedeutung des primären Infektfokus für die Morbidität und Mortalität bei Patienten mit Sepsis
(2017-10-23)a comparison of the outcome of patients with sepsis in view of infection site, especially nosocomial pneumonia, intraabdominal infection and primary bacteremia -
Metabolisches Syndrom: Die Effekte von 20-Hydroxyecdyson und 17β-Östradiol auf den Knochen und die Muskulatur der ovarektomierten Ratte
(2017-07-12)Effects on musculature and bone were shown in ovariectomized rats after 4 weeks application of ecdysone and estradiol. -
Untersuchung zum Zusammenhang zwischen parodontaler Gesundheit sowie Anzahl der Restbezahnung und LBP (big42), CD14 und CD68 am humanen Ventrikelmyokard
(2017-02-24)The aim of this study was to detect coherence between the severity of both periodontal disease as well as the amount of missing teeth and the expression of different markers of inflammation, such as CD68, CD14 and LBP ... -
Effekt von Estradiol und Cimicifuga racemosa (C001) BNO1055 und deren Subfraktionen (C001/S1-S3, R1-R3) auf das Fett- und Muskelgewebe sowie auf Serumparameter der ovarektomierten Ratte
(2016-10-26)Climacteric complaints of postmenopausal women are often treated using hormone replacement therapy. This treatment is effective, but it is also linked to a higher risk of cardiovascular diseases or breast cancer. Research ... -
Assoziation des PDCD1 rs11568821 GG-Genotyps mit stärkerer Morbidität bei Intensivpatienten mit Krankheitsbild Sepsis: Vergleich der SOFA-Sub-Scores
(2016-06-20)The failing of various therapeutic agents in the treatment of sepsis elucidates the still existing lack of knowledge of this syndrome. Over the last years a major change has taken place as results have shown that, beside ... -
The Inhibition of RNA-Polymerase II-Mediated Expression by the Non-Structural Protein NSs of the Oropouche Virus and Establishing an Oropouche Virus Minireplicon System
(2015-06-02)The OROV is a RNA virus that has a segmented, single stranded genome of negative polarity. It belongs to the Bunyaviridae family. Infection by the OROV causes an acute very debilitating febrile episode. This RNA virus is ... -
Upregulation of MC4R in rat liver regeneration
(2014-07-22)BACKGROUND: Melanocortin 4 receptor (MC4R) is predominantly recognized to mediate energy metabolism and anti-inflammation through the central nervous system. However, the expression of MC4R has recently been identified in ... -
Der Effekt von Cimicifuga racemosa BNO 1055-Subfraktionen auf Leberfettgehalt, Kolonepithel und ausgewählte Blutlipidparameter
(2014-04-22)Die Nachfrage nach Alternativen für die Hormonersatztherapie durch Östrogene (HET) zur Linderung menopausaler Beschwerden hat aufgrund ihres Risikoprofils zugenommen. Die entstandene Lücke bei der Behandlung moderater ... -
Untersuchungen zur Assoziation genetischer Polymorphismen im Gen des Endotoxinrezeptors CD14 mit der transkriptionellen Aktivität
(2011-01-20)Association of the polymorphism rs2569190 within the CD14 endotoxin receptor gene with various disease conditions containing an inflammatory component and further in vitro experiments with ...