Dokumente Human- und Zahnmedizin nach Gutachter "Reichardt, Holger Prof. Dr."
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Dendritisches Polyglycerolsulfat als neues Therapeutikum der akuten GvHD
(2024-04-26)Despite decades of research, acute GvHD (aGvHD) remains to be one of the leading causes of increased mortality and morbidity for patients following stem cell transplantation. Due to the limited therapeutic options for the ... -
Assoziationen psychometrisch erfasster Parameter mit Markern der Immunaktivierung bei Patientinnen und Patienten mit depressiven Syndromen
(2022-10-17)Depressive syndromes and their comorbidities are associated with a substantial psychological and somatic suffering, which significantly affect the general health, quality of life, as well as social and occupational activities ... -
Die Rolle des Glukokortikoid-Rezeptors bei der Colitis Ulcerosa im Mausmodell
(2022-09-20)Chronic inflammatory bowel diseases such as ulcerative colitis are widespread diseases that significantly reduce the quality of life of those affected by symptoms such as abdominal pain, diarrhea and weight loss. In addition, ... -
Role of the glucocorticoid receptor in the development of ulcerative colitis and colorectal carcinoma in a murine model
(2022-08-29)For many decades, glucocorticoids (GCs) have been an essential pillar of the therapy of many inflammatory diseases. The beneficial effects of this class of hormones occur quickly and reliably after administration, although ... -
Auswirkungen der Hautbarrierestörung in Filaggrin- und Hornerin(FlgHrnr)-defizienten Mäusen auf den atopischen Marsch
(2022-03-17)Loss-of-function mutations in skin barrier proteins, such as filaggrin (Flg) and hornerin (Hrnr), are known major risks for atopic dermatitis (AD) and the further development of asthma, a process known as atopic march. The ... -
In-ovo-Analysen zur Interaktion von Hodgkin-Lymphomzellen mit Monozyten
(2021-10-18)Classical Hodgkin lymphoma (cHL) is an aggressive B-cell neoplasm. Despite exceptional treatment response rates, the current strategy of risk stratification in cHL implies a relevant proportion of patients being over- or ... -
Auswirkung der TLR4-Inhibition bei verschiedenen Applikationswegen im Modell des ischämischen Schlaganfalls
(2020-11-10)Stroke is one of the most common diseases today and one of the leading causes for physical and psychological disability. Except of the recanalisation therapies that have been established there are no other therapeutical ... -
Beeinflussung des Verlaufs von Pneumokokken-Meningitis in Mäusen durch Stimulation mit einem Cytosin-Guanin-haltigen Oligonukleotid
(2020-01-28)Streptococcus pneumoniae is the most common cause of bacterial meningitis in small children, the elderly and in immunocompromised patients. The aim of this study was therefore, to test if a single intraperitoneal injection ... -
Einfluss von Mifamurtid auf die Makrophagen-induzierte Tumorinvasion von Brustkrebszellen
(2019-07-31)Worldwide, breast cancer is the most-common invasive cancer in women. Despite of advancing treatment options, women still die due to dissemination and metastasis formation. It is known that tumor-associated macrophages ... -
Anti-entzündliche Wirkungen in vitro durch Dimethylfumarat und NF-kB-Inhibitoren
(2018-09-17)Fumaric acid esters, dimethyl fumarate (DMF) in particular, have been established for the therapy of psoriasis and became increasingly important for other chronic diseases like multiple sclerosis. Because of a good ... -
Die Rolle des ko-stimulatorischen Moleküls CD28 in verschiedenen Phasen der EAE
(2018-01-17)This dissertation summarizes the different effects of the co-stimulating molecule CD28 in different phases of EAE, especially regarding the effects on activation markers (e.g. CD44), pro-inflammatory cytokines (like IFN-y ... -
Die Rolle des antiapoptotischen Gens Gimap5 für die Pathogenese neuroinflammatorischer Erkrankungen
(2017-11-06)T-cell lymphopenia is a major risk factor for autoimmunity. A loss-of-function mutation in the Gimap5 gene leads to a reduction in peripheral T-cell numbers in Congenic Lewis rats. Gimap5-deficient Lewis rats developed ... -
Inhibition of the kinase Wee1 - Cytotoxic mechanisms and autoprotection by the tumor suppressor p53
(2017-10-27)The combination of the Wee1 inhibitor MK-1775 and gemcitabine is highly efficient in killing cancer cells in vitro and in mouse xenograft experiments, but the complete molecular mechanism of this potent sensitizing effect ... -
Wirkmechanismen von Glukokortikoiden im Mausmodell der EAE – Einfluss auf Effektor- und Bystander-T-Zellen und Relevanz der T-Zell-Apoptose
(2015-11-05)In the present study, mechanisms of glucocorticoid (GC) therapy were investigated using experimental autoimmune encephalomyelitis (EAE), an animal model of multiple sclerosis. For this purpose, active EAE was induced in ... -
Immunomodulatory activity of murine keratinocyte-derived exosomes
(2015-01-07)Keratinocytes are able to influence cutaneous immunity by taking part in innate as well as in adaptive immune processes. To fulfill this task, the production of soluble factors has a key role. Exosomes, small membrane ... -
Neuartige Wirkmechanismen und Therapiestrategien von Glukokortikoiden in der Behandlung von Multipler Sklerose im Tiermodell
(2014-06-24)Despite the enormous progress being made in the development of new therapies, such as monoclonal antibodies, GCs are still one of the best options available to treat inflammatory diseases. One of the main drawbacks of this ... -
Der Einfluss unterschiedlicher Zellkulturmedien auf die Makrophagen in einem Co-Kultur-Modell von Nervengewebe und Peritonealzellen
(2014-05-08)During Wallerian degeneration in the central or peripheral nervous system the migration of macrophages to the injured tissue can be observed. Then these cells phagocytize the accruing myelin and axon debris at the injury ... -
Hemmung des β-zellspezifischen Transkriptionsfaktors MafA durch die Dual Leucine-Zipper-Kinase (DLK)
(2013-05-27)Pathophysiology of diabetes mellitus type 2 is characterized through progressive loss of functional β-cell-mass with inadequate insulin biosynthesis and insulin secretion. Insulin gene transcription is an important β-cell ... -
Klonierung und Expression einer extrazellulären Lipase von A. fumigatus
(2012-05-15)In Germany every year a great number of people contract invasive mould mycosis initiated by the fungus Aspergillus fumigatus. Almost solely severe immunocompromised patients are being affected. The infection with A. fumigatus ... -
Untersuchungen zur Rekrutierung myeloischer Zellen in einem Tiermodell der Alzheimerschen Erkrankung
(2012-01-30)Reactive myeloid cells in the central nervous system (CNS) are a hallmark of Alzheimer's Disease (AD) pathology but their exact role in pathogenesis is an issue of controversial debate. ...