Browsing Human- und Zahnmedizin by Referee "Ströbel, Philipp Prof. Dr."
Now showing items 1-20 of 33
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Molekulare Charakterisierung von kolorektalen Lebermetastasen mit unterschiedlichen histopathologischen Wachstumsmustern
(2024-12-12)Colorectal cancer liver metastases express different histopathological growth patterns. The three common ones are the replacement, the desmoplastic, and the pushing histopathological growth patterns. Whereas the both latter ... -
Role of FOXM1, GPX1, and CCNB1 in cisplatin resistance in malignant thymomas and thymic carcinomas
(2024-12-02)Cisplatin resistance in malignant thymomas and thymic carcinomas remains a significant challenge, impairing therapeutic efficacy and patient outcomes. This study investigates the roles of Glutathione Peroxidase 1 (GPX1), ... -
Zur Rolle von EZH2 in neuroendokrinen Neoplasien
(2024-11-29)Neuroendocrine neoplasms are rare neoplasms with an increasing incidence, primarily occurring in the gastroenteropancreatic region and the lungs. They are classified into the prognostically more favorable NET and the less ... -
Die Bedeutung des Immunoproteasoms in der Behandlung epithelialer Thymustumoren
(2024-10-28)Thymic epithelial tumors are rare neoplastic diseases of the thymus and are divided into thymomas and thymic carcinomas based on their histopathological characteristics. Surgical tumor resection is the first choice of ... -
Die Rolle der Glykogen Synthase Kinase 3β in der Regulation von DNS-Schäden und Chemotherapieresistenz im Pankreaskarzinom
(2024-09-24)Pancreatic carcinoma is one of the most aggressive solid tumour types and is characterized by pronounced molecular heterogeneity. Research is continuing into molecularly definable subgroups that are suitable for targeted, ... -
Evaluation MikroRNA-basierter Biomarker für das Karzinom der Mundhöhle: hsa-miR-149-5p und hsa-miR-182-5p als neue Prognosemarker
(2024-09-16)Oral squamous cell carcinoma (OSCC) is among the leading cancer types worldwide and a major cause of cancer morbidity and mortality: The 5-year-survival rate remains less than 50% due to high rates of recurrence and lymph ... -
Charakterisierung muriner und humaner Tumoren mit besonderem Fokus auf die Immunzellinfiltration mittels innovativer bildgebender Verfahren
(2024-08-23)3D imaging of the immune cell status in a complex tumour volume represents an important step towards understanding the anti-tumour immune response and a decisive predictor of the efficacy of immune checkpoint inhibition. ... -
Klinische Validierung hochgradiger MET-Amplifikationen in nicht-kleinzelligen Lungenkarzinomen
(2024-07-18)Lung cancer remains one of the most common types of cancer worldwide. Despite intensive research, the prospects for survival are extremely poor, especially in advanced stages or in the event of metastasis. MET tyrosine ... -
Fluoreszenz-in-situ-Hybridisierung und funktionelle Analyse der KMT2A-MAML2 Translokation in epithelialen Thymusneoplasien und den humanen Zelllinien 1889c und MP-57
(2024-04-25)Thymoma and thymic carcinoma are very rare epithelial neoplasms of the thymus. Little is known about the pathogenesis of these tumors. Targeted therapeutic approaches have hardly been established to date, and the recurrence ... -
Regulation and therapeutic targeting of MTHFD2 and EZH2 in KRAS mutated human pulmonary adenocarcinoma
(2023-07-17)With nearly 40 %, pulmonary adenocarcinomas are the main subgroup of non-small cell lung cancers. Activating KRAS mutations occur in about 30 % of pulmonary adenocarcinoma cases and the discovery of the G12C KRAS ... -
Charakterisierung der Immunantwort auf Sentinel-Lymphknoten-Metastasen beim malignen Melanom
(2023-02-23)Malignant melanoma is an immunogenic tumor that in most cases triggers an immunological defense reaction. In order to better understand the immunological processes, metastases of melanoma found in sentinel lymph nodes, as ... -
Genetische Varianten von PPM1D und TP53 bei Patienten mit myelodysplastischen Syndromen und komplex-aberranten Karyotypen
(2023-02-07)Myelodysplastic syndromes (MDS) are a heterogenous group of clonal bone marrow diseases leading to ineffective hematopoiesis. In over 90% cyto- and molecular genetic aberrations can be detected with complex aberrations ... -
Die Funktionsanalyse der Caspase-3 und des Yes-associated Proteins in epithelialen Thymusneoplasien
(2023-02-07)Thymic neoplasms are very rare neoplasms in the thymus that arise from the epithelium of the thymus, located in the mediastinum. Little is known about their etiopathogenesis, but they represent the adult tumor entity with ... -
Differentielle Methylierung von H3K27 in EZH2 positiven large cell neuroendokrinen Tumoren des Thymus
(2023-02-02)Neuroendocrine thymic tumors represent only 0.4% of all neuroendocrine tumors and are thus very rare. Four subtypes are classified by the WHO. A high-grade subtype is the large cell neuroendocrine carcinoma, which is ... -
Proteomische Analyse von neuroendokrinen Tumoren des Thymus und der Lunge
(2022-12-12)Neuroendocrine tumours of the thymus are very rare neoplasms. The closest related group of tumours are neuroendocrine tumours of the lung. Both are classified using the same criteria into four subtypes: typical carcinoid, ... -
Histopathologische Charakterisierung von Muskelzellstress bei der Einschlusskörpermyositis
(2022-11-09)Inclusion body myositis (IBM) is the most common idiopathic inflammatory myopathy of an advanced age. According to the histopathological features in IBM biopsies, IBM is thought to involve an interplay of inflammation, ... -
Funktionelle und mechanistische Charakterisierung von EZH2 in Atm-defizienten Subtypen des Pankreaskarzinoms
(2022-11-09)Pancreatic ductal adenocarcinoma (PDAC) is predicted to be the second cancer associated cause of death after lung cancer by 2030. The dismal prognosis of PDAC is mainly driven by its resistance towards common cancer therapies ... -
Klinisches Outcome und die prognostische Relevanz von Tumorstammzellmarkern bei Speicheldrüsenmalignomen
(2022-10-07)Salivary gland carcinomas show a low incidence with a broad range of pathological entities and a poor prognosis in the advanced stage, therefore early detection of the disease with a straightforward testing of a biomarker ... -
Proteomische Analyse von Plattenepithelkarzinomen des Kopf-Hals-Bereichs und Plattenepithelkarzinomen der Lunge
(2022-07-26)Patients with squamous cell carcinoma of the head and neck may develop both lung metastasis and metachronous squamous cell carcinoma of the lung due to shared risk factors such as tobacco smoke. Distinguishing between these ... -
Retrospektive Analyse von an der Universitätsmedizin Göttingen (UMG) behandelten Patienten und Patientinnen mit kolorektalen Karzinomen im Zeitraum 2000 bis 2020 und Korrelation der klinischen Parameter mit Proteinanalysen
(2022-06-23)Background: In regard of the Warburg-effect and the progressively more personalised therapy and prognostic options available, based on molecular biology research, the EGFR- and Glycolysis receptor proteins present an ever ...