Dokumente Human- und Zahnmedizin nach Gutachter "Ströbel, Philipp Prof. Dr."
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Fluoreszenz-in-situ-Hybridisierung und funktionelle Analyse der KMT2A-MAML2 Translokation in epithelialen Thymusneoplasien und den humanen Zelllinien 1889c und MP-57
(2024-04-25)Thymoma and thymic carcinoma are very rare epithelial neoplasms of the thymus. Little is known about the pathogenesis of these tumors. Targeted therapeutic approaches have hardly been established to date, and the recurrence ... -
Regulation and therapeutic targeting of MTHFD2 and EZH2 in KRAS mutated human pulmonary adenocarcinoma
(2023-07-17)With nearly 40 %, pulmonary adenocarcinomas are the main subgroup of non-small cell lung cancers. Activating KRAS mutations occur in about 30 % of pulmonary adenocarcinoma cases and the discovery of the G12C KRAS ... -
Charakterisierung der Immunantwort auf Sentinel-Lymphknoten-Metastasen beim malignen Melanom
(2023-02-23)Malignant melanoma is an immunogenic tumor that in most cases triggers an immunological defense reaction. In order to better understand the immunological processes, metastases of melanoma found in sentinel lymph nodes, as ... -
Genetische Varianten von PPM1D und TP53 bei Patienten mit myelodysplastischen Syndromen und komplex-aberranten Karyotypen
(2023-02-07)Myelodysplastic syndromes (MDS) are a heterogenous group of clonal bone marrow diseases leading to ineffective hematopoiesis. In over 90% cyto- and molecular genetic aberrations can be detected with complex aberrations ... -
Die Funktionsanalyse der Caspase-3 und des Yes-associated Proteins in epithelialen Thymusneoplasien
(2023-02-07)Thymic neoplasms are very rare neoplasms in the thymus that arise from the epithelium of the thymus, located in the mediastinum. Little is known about their etiopathogenesis, but they represent the adult tumor entity with ... -
Differentielle Methylierung von H3K27 in EZH2 positiven large cell neuroendokrinen Tumoren des Thymus
(2023-02-02)Neuroendocrine thymic tumors represent only 0.4% of all neuroendocrine tumors and are thus very rare. Four subtypes are classified by the WHO. A high-grade subtype is the large cell neuroendocrine carcinoma, which is ... -
Proteomische Analyse von neuroendokrinen Tumoren des Thymus und der Lunge
(2022-12-12)Neuroendocrine tumours of the thymus are very rare neoplasms. The closest related group of tumours are neuroendocrine tumours of the lung. Both are classified using the same criteria into four subtypes: typical carcinoid, ... -
Histopathologische Charakterisierung von Muskelzellstress bei der Einschlusskörpermyositis
(2022-11-09)Inclusion body myositis (IBM) is the most common idiopathic inflammatory myopathy of an advanced age. According to the histopathological features in IBM biopsies, IBM is thought to involve an interplay of inflammation, ... -
Funktionelle und mechanistische Charakterisierung von EZH2 in Atm-defizienten Subtypen des Pankreaskarzinoms
(2022-11-09)Pancreatic ductal adenocarcinoma (PDAC) is predicted to be the second cancer associated cause of death after lung cancer by 2030. The dismal prognosis of PDAC is mainly driven by its resistance towards common cancer therapies ... -
Klinisches Outcome und die prognostische Relevanz von Tumorstammzellmarkern bei Speicheldrüsenmalignomen
(2022-10-07)Salivary gland carcinomas show a low incidence with a broad range of pathological entities and a poor prognosis in the advanced stage, therefore early detection of the disease with a straightforward testing of a biomarker ... -
Proteomische Analyse von Plattenepithelkarzinomen des Kopf-Hals-Bereichs und Plattenepithelkarzinomen der Lunge
(2022-07-26)Patients with squamous cell carcinoma of the head and neck may develop both lung metastasis and metachronous squamous cell carcinoma of the lung due to shared risk factors such as tobacco smoke. Distinguishing between these ... -
Retrospektive Analyse von an der Universitätsmedizin Göttingen (UMG) behandelten Patienten und Patientinnen mit kolorektalen Karzinomen im Zeitraum 2000 bis 2020 und Korrelation der klinischen Parameter mit Proteinanalysen
(2022-06-23)Background: In regard of the Warburg-effect and the progressively more personalised therapy and prognostic options available, based on molecular biology research, the EGFR- and Glycolysis receptor proteins present an ever ... -
Comparative Morphologic and Molecular Classification of Neuroendocrine Tumors of the Thymus in Humans
(2021-04-30)Neuroendocrine tumors (NET) of the thymus are rare neoplasms that share many similarities with their pulmonary counterpart. The WHO 2015 classification of thymic and pulmonary NET divides tumors into typical and atypical ... -
Präklinische Analyse von epithelialen und stromalen Markern in einem transgenen Mausmodell für Pankreaskarzinome
(2021-01-12)Pancreatic ductal adenocarcinoma is amongst the most aggressive cancers and is associated with an extremely poor prognosis. From a histological perspective, pancreatic cancer is char-acterised by a distinct, widespread ... -
Urokinase-type plasminogen activator receptor contributes to chemosensitivity and epithelial-to-mesenchymal transition in PDAC
(2020-10-26)Purpose: Pancreatic ductal adenocarcinoma (PDAC) is the most frequent maliganancy of the pancreas and the fourth most lethal cancer with a 5-year overall survival rate of < 5 %. Patients with a gene amplification in the ... -
Untersuchung spezifischer Inhibitoren der PI3K-Signalkaskade zur Therapie des Lymphangioms
(2020-07-06)Lymphatic malformations (LM; lymphangiomas) are benign congenital malformation disorders of the lymphatic system and are characterized by cystic lymphatic enlargements. A distinction is made between the macrocystic, ... -
Identifizierung von Patientinnen und Patienten mit der hereditären Form des Mamma- und Ovarialkarzinoms mittels Next-Generation-Sequencing-(NGS)-Technologie
(2019-06-11)Breast cancer is the most frequent malignant female cancer. Beside sporadic forms, 5 % - 10 % of these cancers show a hereditary origin with an identified germline mutation. The main purpose of this study was to analyse ... -
Experimentelle genetische und proteomische Identifikation von diagnostischen und prognostischen Biomarkern epithelialer Thymustumoren
(2019-03-07)Thymomas and thymic carcinomas are the most common primary mediastinal tumors of the adult. Therapy strategies of thymic epithelial tumors are based on the histological WHO classification. Reviews pictured the low ... -
uPAR und c-MYC beim duktalen Adenokarzinom des Pankreas
(2018-08-16)The dismal prognosis of pancreatic cancer is closely related to aggressive tumor development that leads to diagnosis in advanced stages and limited curative concepts. Urokinase-type plasminogen activator receptor (uPAR) ... -
FRET-Bildgebung zum Nachweis der Phopshorylierung der anaplastic lymhoma kinase (ALK) im nicht-kleinzelligen Bronchialkarzinom
(2018-05-22)Background: Anaplastic lymphoma kinase (ALK) is an oncogenic driver mutation in T-cell lymphoma and NSCLC. Small molecule inhibitors are available. Treatment decisions are mostly made on ALK expression but their efficacy ...