Browsing Fakultät für Biologie und Psychologie (inkl. GAUSS) by Advisor "Braus, Gerhard Prof. Dr."
Now showing items 1-20 of 40
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The velvet protein Vel1 controls initial plant root colonization and conidia formation for xylem distribution in Verticillium wilt
(2021-08-24)The velvet family of regulatory proteins is well-conserved in fungi and links developmental processes and secondary metabolite production. These proteins comprise a velvet domain for DNA binding and dimerization with ... -
Developmental regulators and secreted effector molecules of the fungal pathogen Verticillium spp.
(2020-09-29)The haploid Verticillium dahliae and the allodiploid V. longisporum are two filamentous fungal pathogens, which colonize the plant vascular system of a broad host range including important crops. They survive outside of ... -
Interplay of Verticillium signaling genes favoring beneficial or detrimental outcomes in interactions with plant hosts
(2020-07-14)Verticillia and their plant hosts both contribute to pathogenesis as a consequence of their interaction. Evolution-driven genome extension includes hybridization, resulting in amphidiploid species as the rapeseed pathogen ... -
Specific ubiquitin-dependent protein degradation requires a trimeric CandA complex in Aspergillus nidulans
(2019-05-20)E3 cullin-RING ubiquitin ligase complexes are activated by modification of their cullin scaffold protein with the ubiquitin-like modifier Nedd8. Deneddylases as the COP9 signalosome (CSN) or Den1/A interact and destabilize ... -
Verticillium dahliae transcription factors Som1 and Vta3 control microsclerotia formation and sequential steps of plant root penetration and colonisation to induce disease
(2018-10-12)Verticillium dahliae belongs to the soil-borne ascomycete fungi. It causes wilt diseases and early senescence in more than 200 plant species including economically important crops. It can exist in the soil without a host ... -
C-terminal tyrosine residue modifications modulate α-synuclein toxicity in yeast as unicellular model for Parkinson´s disease
(2016-12-07)The presence of protein inclusions called Lewy bodies (LBs) that are mainly composed of misfolded and accumulated α-synuclein (αSyn) represents a hallmark of Parkinson´s disease (PD). Oligomeric αSyn species are thought ... -
Stress Response SCF Ubiquitin Ligase F box Protein Fbx15 Controls Nuclear Co repressor Localization and Virulence of the Opportunistic Human Fungal Pathogen Aspergillus fumigatus
(2016-09-06)Aspergillus fumigatus is the most prevalent cause for pulmonary infections in immuno-compromised patients. Virulence factors are often linked to developmental control mechanisms, which are often identified in the closely ... -
Phosphorylation dependent stability control of the deneddylase DenA and its impact on Aspergillus nidulans development
(2016-04-05)Summary Malfunctioning protein degradation in higher eukaryotes is associated with numerous diseases, including neurodegenerative disorders and cancer. Understanding regulation mechanisms of protein degradation is thus ... -
Roles of the Cpc1 regulator of the cross-pathway control in the Verticillium plant pathogens
(2014-06-20)Verticillium longisporum is a soil-borne fungal pathogen of oilseed rape (Brassica napus). Infection is initiated by hyphae from germinating microsclerotia which invade the plant vascular system through penetration of the ... -
Characterization of the pathogenicity relevant genes THI4 and PA14_2 in Verticillium dahliae
(2014-02-17)Verticillium is a soil-borne plant pathogen including species that are distributed all over the word. Up to now no fungicides could avoid an infection on host plants. In resting structures, (microscrlerotia, melanized ... -
Alterations in gene expression and secondary metabolite production during development of Aspergillus nidulans
(2014-02-10)Many studies describing development and secondary metabolism of the filamentous fungus Aspergillus nidulans contributed to a better understanding of fungal secondary metabolism regulation at the molecular level. However, ... -
The sumoylation and neddylation networks in Aspergillus nidulans development
(2013-10-22)Proteins can be post-translationally modified by the attachment of members of the ubiquitin-like protein family which requires the action of three enzymatic steps. The protein becomes activated by an E1 enzyme, transferred ... -
Secondary metabolism and development in the filamentous fungus <i>Aspergillus nidulans</i> - Activation of silent gene clusters and characterization of the SAM synthetase SasA
(2012-12-07)Antimicrobial resistance is spreading whereas the number of newly discovered antibiotics is declining. The genomes of filamentous fungi comprise numerous putative gene clusters coding for biosynthetic enzymes of structurally ... -
Deneddylation and fungal development - Regulation of Nedd8 protein modification by DenA and the COP9 signalosome
(2012-08-16)Ubiquitin dependent protein degradation is a common principle in eukaryotic organisms to control appropriate temporal and spatial protein levels. Abnormal regulation leads to embryonic lethality in plants, insects and ... -
α-synuclein in Saccharomyces cerevisiae: model for aggregate clearance, cell survival and influence of autophagy
(2012-06-26)α-synuclein is a neuronal protein involved in several neurodegenerative disorders, including Parkinson's Disease (PD). Misfolding and accumulation of α-synuclein into cytoplasmic inclusions correlate with the pathogenesis ... -
The role of Pcl5p and Pcl7p in the Gcn4p stability regulation of Saccharomyces cerevisiae
(2011-05-09)In the baker s yeast Saccharomyces cerevisiae, the transcriptional activator Gcn4p is the central element of the general amino acid control network that induces more than 500 genes in ... -
Translational control by the ribosomal protein Asc1p/Cpc2p in Saccharomyces cerevisiae
(2011-04-14)The mRNA-specific control of translation is of great importance for the adjustment to environmental changes, as e.g. amino acid limitations. It is especially mediated through the mRNA-5 ... -
Regulation of septum formation by RHO4 GTPase signalling in Neurospora crassa
(2010-07-20)Cytokinesis, the process in which a single cell is separated into two daughter cells, is highly conserved from plants to fungi and animals. Consistent with being key regulators of many ... -
Regulation of fungal polar tip extension through NDR kinase signalling
(2010-07-20)NDR kinases play an important role in cell differentiation and morphogenesis. Until now, not much is known about the regulation of NDR kinases and the cross-communication between individual ... -
Oxygen-dependent regulation of the activating transcription factor-4 (ATF-4)
(2010-01-21)The prolyl-4 hydroxylase domain enzymes 1-3 (PHD1-3) are involved in regulating the protein stability of the alpha subunit of the hypoxia inducible factor (HIF), which is the master regulator ...