Dokumente Fakultät für Biologie und Psychologie (inkl. GAUSS) nach Gutachter "Braus, Gerhard Prof. Dr."
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A genetic system to study the nuclear pore complex permeability barrier of the yeast Saccharomyces cerevisiae
(2012-11-20)All nucleocytoplasmic transport occurs through nuclear pore complexes (NPCs). To hinder uncontrolled mixing of cytoplasmic and nuclear content, NPCs maintain the permeability barrier that suppresses passage of inert macromolecules ... -
Adhesion of the rapeseed pathogen Verticillium longisporum to its host Brassica napus: Uncovering adhesion genes and the evolutionary origin of the fungus
(2011-05-06)Verticillium longisporum, a soil-borne plant pathogen, is an emerging problem for oilseed rape and other crucifers. The mechanism of infection through plant roots and the evolutionary origin of this fungus are still not ... -
Alterations in gene expression and secondary metabolite production during development of Aspergillus nidulans
(2014-02-10)Many studies describing development and secondary metabolism of the filamentous fungus Aspergillus nidulans contributed to a better understanding of fungal secondary metabolism regulation at the molecular level. However, ... -
Analyse der UPR vermittelten Stressantwort und ihrer Funktion während der biotrophen Entwicklung von<i> Ustilago maydis</i>
(2016-12-09)The unfolded protein response (UPR) is a conserved eukaryotic signaling network that is activated by accumulation of misfolded proteins in the endoplasmic reticulum (ER) to ensure protein homeostasis. In the baker's yeast ... -
Analyse des Kreuzungstyp-Locus des filamentösen Ascomyceten Sordaria macrospora
(2010-12-06)Sex as a mechanism for the exchange of genetic material between individuals is a broadly conserved and tightly regulated process in different species. In the class of ascomycetes the ... -
Analyses of the Life Cycle of TLC1 and the Nuclear RNA Quality Control System in Saccharomyces cerevisiae
(2015-04-24)During genome replication, chromosomes undergo a progressive shortening of their ends. To counteract this loss, a complex named telomerase functions as a reverse transcriptase to elongate telomeres. In Saccharomyces ... -
Analysis of Clp1-dependent UPR modulation in Ustilago maydis
(2019-06-13)The unfolded protein response (UPR) is a conserved signaling pathway, that is present in all eukaryotic cells and ensures endoplasmic reticulum (ER) homeostasis under stress conditions. In the phytopathogenic fungus U. ... -
Analysis of Neuronal Diseases in the Model Organism <i>Aspergillus nidulans</i>
(2008-12-11)Neuronal diseases can include abnormal aggregation of key proteins or the dysfunction of transport processes during the development of nerve cells. Parkinson s disease (PD) is a neurodegenerative ... -
Anti-Apoptosis and Regeneration in the Visual System: Effects of BAG1 (Bcl-2-associated athanogene-1)
(2008-04-28)In the present work, we investigated Bcl-2-associated athanogene-1 (BAG1) as a therapeutic molecule in the lesioned visual system in vivo. The effects of BAG1 were tested in two in vivo models of apoptosis and regeneration, ... -
Biochemical Characterization of <i>Toxoplasma gondii</i> Type II NADH Dehydrogenases - Physiological Impact on Mitochondrial Functions and Energy Metabolism
(2010-03-09)The single subunit mitochondrial type II NADH dehydrogenases (NDH2s) in apicomplexan parasites have been considered as potential drug targets due to the absence in mammalian cells. Toxoplasma ... -
Biogenesis of respiratory chain: Rcf1 and Rcf2 as a novel assembly factors
(2012-07-04)The mitochondrial respiratory chain consists of four membrane-embedded electron transport complexes (complexes I – IV) and the ATP synthesizing F1F0ATPase. Within the inner mitochondrial membrane these complexes assemble ... -
Biosynthesis of Aromatic Amino Acids in Yeast and Aspergillus
(2001-02-22)Chorismate mutases (E.C. 5.4.99.5) catalyse the Claisen rearrangement of chorismic acid to prephenate, the first reaction of the tyrosine/phenylalanine-specific branch of aromatic amino acid biosynthesis. Within this ... -
Characterization of a novel regulator of the unfolded protein response in Ustilago maydis and mammals
(2019-07-16)The endoplasmic reticulum (ER) is an eukaryotic organelle which is the entry point into the secretory pathway and responsible for protein synthesis and processing. The amount of proteins to be folded in the ER lumen is ... -
Characterization of alternative NADH dehydrogenases in the respiratory chain of Toxoplasma gondii as a novel drug targets
(2006-11-06)The single mitochondrion of Toxoplasma gondii generates a membrane potential in the proliferative tachyzoite stage. However, its contribution to energy metabolism in dormant bradyzoites is ... -
Characterization of an Arabidopsis glutaredoxin that interacts with core components of the salicylic acid signal transduction pathway
(2006-05-16)Salicylic acid (SA) is a plant signalling molecule that mediates the induction of defense responses upon attack by a variety of pathogens. Activation sequence-1 (as-1) type cis elements and ... -
CHARACTERIZATION OF BACTERIAL LIPOPOLYSACCHARIDES (Pseudomonas syringae pv. tomato and Pseudomonas syringae pv. apii) AND PECTINS OF TOMATO AND CELERY PLANTS (Lycopersicon esculentum and Apium graveolens) REGARDING THEIR POSSIBLE ROLE IN HOST/PATHOGEN-INTERACTION
(2002-10-15)All plants face a formidable challenge of defending themselves against a large number of pathogens. The interactions between a pathogen and its host are governed by a number of factors. ... -
Characterization of the cell wall protein Ecm33 family in Candida glabrata
(2013-09-05)Candida glabrata is the second most frequent cause of local and systemic human candidiasis and infections with this species are difficult to treat because of frequent azole resistance. C. glabrata infections have high ... -
Characterization of the pathogenicity relevant genes THI4 and PA14_2 in Verticillium dahliae
(2014-02-17)Verticillium is a soil-borne plant pathogen including species that are distributed all over the word. Up to now no fungicides could avoid an infection on host plants. In resting structures, (microscrlerotia, melanized ... -
Charakterisierung der bradyzoitspezifisch exprimierten P-Typ Plasmamembran ATPase TgPMA1 in <i>Toxoplasma</i> <i>gondii</i>
(2003-09-02)Toxoplasma gondii is an obligate intracellular parasite that causes persistent infections in a broad range of warm-blooded vertebrates, including humans. A stage differentiation ... -
Charakterisierung der Eaf 1-Funktion für die Biogenese der Aminopeptidase 1
(2008-11-10)In Saccharomyces cerevisiae the leucine exopeptidase aminopeptidase 1 (Ape1) is synthesized as a cytosolic precursor. After oligomerisation to a homododecameric complex the enzyme gets ...