Browsing Fakultät für Biologie und Psychologie (inkl. GAUSS) by Referee "Engel, Wolfgang Prof. Dr. Dr."
Now showing items 1-15 of 15
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Functional Analysis of Two Major Sperm Tail Proteins Identifies ODF1 as Being Essential for the Tight Linkage of the Sperm Head to the Tail via SPAG4 and ODF2 as A Component of the β-catenin Destruction Complex
(2015-04-02)In the mammalian sperm tail, the outer dense fibers (ODFs) are accessory fibers accompanying the axonemal tubuli doublets on their outer site. The ODFs are composed of at least 14 polypeptides of which only a few have been ... -
Modelling genetic heart diseases with patient-specific induced pluripotent stem cells
(2014-09-23)Brugada syndrome (BrS), a cardiac genetic disease, is one of the major causes of sudden cardiac death in healthy young people. However, the underlying electrophysiological and molecular mechanisms have not been completely ... -
Analyse zur Rolle von pflanzlichen Wirkstoffen und Histondeacetylase-Inhibitoren auf Wachstumsfaktoren und deren Signalwege in Prostatakarzinomzellen
(2013-12-19)Prostate cancer (PCa) is the most frequently new diagnosed cancer entity and the third leading cause of cancer-related deaths of men in Germany. The options for therapy of PCa are restricted and most of them have strong ... -
Die Rolle des IKK/NF-kappaB Signalweges bei der Myelinisierung, De- und Remyelinisierung des zentralen Nervensystems
(2008-08-27)The present thesis aimed to elucidate the function of the classical NF-kappaB pathway in development (myelination), damage (demyelination) and regeneration (remyelination) of myelin sheaths ... -
Expression und Funktion von Caveolin bei glialen Zellen, insbesondere Oligodendrozyten
(2006-07-25)Caveolin-containing microdomains (CMD) are subdomains of the plasma membrane that contain high concentrations of sphingomyelin, glycosphingolipids and cholesterol. They are involved in ... -
Molecular and cellular Mechanisms controlling Primordial Germ Cell Migration in Zebrafish
(2006-06-27)In zebrafish, primordial germ cells (PGCs) are specified early in development then migrate to the area where the gonad will form and differentiate into gametes (eggs and sperm). The ... -
Characterization of the 5-HT7(a) receptor: Specific receptor - G- protein interactions
(2004-08-31)Serotonin (5-hydroxytryptamine, or 5-HT) is very important neurotransmitter which regulates a variety of different physiological processes within the central Nervous System and at the ... -
Entwicklung neuer Markersysteme für die ancient DNA Analyse
(2004-07-28)The reconstruction of living conditions and social structures of people of the past are main challenges of anthropology. In this context, skeletal remains of prehistoric individuals represent ... -
Characterization of the 95 kDa sperm adhesion protein
(2004-03-04)During the early stages of fertilisation, the interaction between the spermatozoa and the oocyte involves complex mechanism. The events of gamete recognition and binding triggers signal ... -
Role of the CD40 receptor/CD154 ligand dyad in the control of smooth muscle cells phenotype
(2003-12-18)In the pathogenesis of atherosclerosis, circulating leukocytes adhere to endothelial cells, migrate through them and enter the vessel wall. CD40, a member of the tumor necrosis factor ... -
DIFFERENTIAL GENE EXPRESSION DURING ISCHEMIA AND REPERFUSION IN AN EXTRACORPOREAL SMALL BOWEL PERFUSION MODEL IN SWINE
(2002-12-04)In a perfusion model using isolated small intestine of the pig, a strong inflammatory reaction with cytokine release and induction of corresponding mRNA expression was shown during reperfusion ... -
Analyse alter DNA zur Ermittlung von Heiratsmustern in einer frühmittelalterlichen Bevölkerung
(2002-05-22)The determination of social structures is one of the main challenges in the reconstruction of early populations. By typing ancient DNA the discovery and validation of biological kinship ... -
Molekulare Analyse der differentiellen Funktionen von Linkerhiston Isoformen bei Caenorhabditis elegans.
(2002-01-29)Linker histones are non-essential for the life on single-celled eucaryotes. Linker histones, however, can be important components of specific developmental programs in multicellular animals ... -
Molekularbiologische und Röntgenmikroskopische Charakterisierung der Heterochromatinproteine des Nematoden Caenorhabditis elegans
(2001-12-12)The nematode C. elegans was the first multicellular organisms whose genome was completely sequenced (The C. elegans Sequencing Consortium, 1998). This model organism is highly eligible for ... -
Ueber die Funktion von Zinkfinger Proteinen bei der Induktion des Mesoderms in Xenopus laevis
(2001-12-10)Mesoderm induction and dorsal-ventral patterning in vertebrates and invertebrates involves signalli ng by members of the transforming growth factor-beta (TGF-beta) superfamily cytokines. ...