Browsing Fakultät für Biologie und Psychologie (inkl. GAUSS) by Referee "Kramer, Wilfried PD Dr."
Now showing items 1-20 of 39
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An mRNA degradation complex in Bacillus subtilis
(2011-12-14)In every organism the degradation of mRNAs is a fundamental process. This step not only recycles nucleotides but also adjusts gene expression due to the availability of the mRNA templates. The main players in this process ... -
Analyse und Charakterisierung regulatorischer Vorgänge in Bacillus licheniformis
(2015-05-08)Analysis of RNA-Seq data in a genome context sensitive approach to identify known and novel RNA-regulatory elements and events applied by Bacillus licheniformis DSM13 to adapt its physiology to a productive fermentation. ... -
Analyses of the Life Cycle of TLC1 and the Nuclear RNA Quality Control System in Saccharomyces cerevisiae
(2015-04-24)During genome replication, chromosomes undergo a progressive shortening of their ends. To counteract this loss, a complex named telomerase functions as a reverse transcriptase to elongate telomeres. In Saccharomyces ... -
Biochemische, molekularbiologische und genetische Untersuchungen über strukturelle Voraussetzungen für DNA U-Endonukleaseaktivität in der ExoIII-Familie von DNA Reparaturenzymen
(2010-03-05)One of the most serious problems in any organism is the spontaneous hydrolytic DNA damage. The problem of U-DNA repair is being intensively studied in thermophilic and hyperthermophilic ... -
Characterisation of the cell wall protein Pga29p in the human pathogenic fungus <i>Candida albicans</i>
(2009-02-17)Candida albicans is an opportunistic fungal pathogen that is responsible for most of the Candida infections in humans. It can cause superficial infections on the mucosa, nails or skin and ... -
Comparative DNA‐Protein Interaction and Epithelial Tight Junctions Modulation Potential of Immunosuppressive Regime
(2016-01-28)Mycophenolic acid (MPA) is an important immunosuppressive drug (ISD) prescribed to prevent graft rejection in the organ transplanted patients. However, its use is sporadically linked to the leak flux diarrhea and other ... -
Effect of radiation on hepatic fat metabolism in rat and mouse: A role of radiation-induced TNF-α in the regulation of FAT/CD36
(2015-08-13)Radiotherapy is an important method to treat tumors. The positive effects of irradiation on tumoral tissue are thought to be due to the damage of the DNA of tumor cells and the damage of tumor vessels. Radiation as single ... -
Einfluss der Immunsuppressiva Cyclosporin A und Everolimus auf die funktionelle DNA-Reparaturfähigkeit sowie auf die Regulation von DNA-Reparatur-Genen
(2009-11-25)Unlike other immunosuppressive drugs including Everolimus, Cyclosporin A causes a dramatic increase of UV-induced skin cancer in transplant patients. The molecular mechanisms of Cyclosporin ... -
Entwicklung eines HTS-geeigneten Enzymtests für Histondeacetylasen zur Entwicklung von HDAC-Inhibitoren
(2004-09-27)During the past years the pivotal role of histone deacetylases (HDACs) in tumourgenesis was discovered. These enzymes then were quickly ranked as molecular targets by the pharmaceutical ... -
Entwicklung von diagnostischen Methoden zum Nachweis von europäischen humanpathogenen Arboviren
(2014-10-17)A majority 50-70% of aseptic meningo-encephalitis cases is caused by unknown aetiological agents.
In the course of this work a cytometric bead array (CBA) for simultaneous detection of antibodies against ...
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Establishment of human lymphoma cell lines with different thiopurine S-methyltransferase (TPMT) activities and differential proteome analysis after thiopurine exposure.
(2013-04-09)Thiopurines are purine analogues used as immunosuppressive and antileukemic agents. Thiopurine activation requires extensive metabolism that involves many enzymatic reactions and TPMT is one of the crucial enzymes in the ... -
Exposition von Proteinen auf der Oberfläche von Escherichia coli Zellen: mechanistische Betrachtung und biotechnologische Anwendung
(2003-12-10)Methods of molecular evolution play an important role for the optimization of biomolecules with respect to function, stability, or interaction. A key aspect is the generation of protein ... -
Expression analysis of Drosophila melanogaster microRNAs
(2007-01-31)miRNAs are tiny regulatory RNAs of 20-25 nucleotides (nt) in length that are endogenously expressed in cells. Hundreds of miRNA genes have been identified in plants and animals. Together they form a large family of regulatory ... -
Feinkartierung humoraler Immunantworten von Makaken nach Immunisierung und/oder viraler Infektion mittels Peptid - Microarray
(2014-10-02)The aim of this study was to map humoral immune responses in rhesus macaques (RM) which had either been immunized and/or infected with different viruses. This was achieved by screening serum samples using peptide microarrays. ... -
Function of MCPH1 in Neurogenesis
(2011-06-22)Primary Microcephaly (MCPH), an autosomal recessive disorder, is characterized by a reduction of the brain size in particular the cerebral cortex size. MCPH can be caused by mutations in ... -
Functional Analysis of the Salicylic Acid-Responsive PR-1 Promoter in Arabidopsis thaliana
(2010-02-04)The Arabidopsis PR-1 gene belongs to a subset of genes upregulated during systemic acquired resistance (SAR), a plant defense response against a broad spectrum of pathogens mediated ... -
Funktionelle Analyse von MHC-Klasse-I-Genen der Rhesusaffen (<i>Macaca mulatta</i>)
(2008-09-01)This thesis focuses on the structure and function of rhesus macaque (Macaca mulatta, Mamu) major histocompatibility complex (MHC) class I genes. As the cellular immune response is at least ... -
Funktionelle Charakterisierung potentieller Pathogenitätsfaktoren aus Pseudomonas aeruginosa mittels biochemischer und evolutiver Methoden
(2005-07-15)Three novel potential pathogenicity factors from the opportunistic pathogen Pseudomonas aeruginosa were characterized functionally and biochemically. The P. aeruginosa mutant 41D3 carries ... -
Genetische Variabilität in der phagozytären NAD(P)H-Oxidase: Funktionelle Charakterisierung und Bedeutung für die Zytostatika-Therapie
(2010-01-05)Cardiotoxicity is a severe side effect of doxorubicin-containing chemotherapy as used in the treatment of several tumors and leukemia and up to 6% of treated patients develop congestive ... -
Identification and characterization of Campylobacter jejuni factors relevant for the infection process
(2007-10-09)Campylobacter jejuni is the most frequent bacterial cause of foodborne-illness in the developed world including Germany, where the reported number is 60,000 cases in a year. Despite the ...