Dokumente Fakultät für Biologie und Psychologie (inkl. GAUSS) nach Gutachter "Schwienhorst, Andreas PD Dr."
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Saccharomyces cerevisiae DNA helicases Mph1, Srs2 and Sgs1 collaborate for the reinitiation of stalled or collapsed replication forks
(2006-08-10)The MPH1 gene from Saccharomyces cerevisiae codes for a DNA helicase involved in the error-free bypass of DNA lesions via homologous recombination. Simultaneous deletion of the MPH1 and ... -
Zur Substratspezifität und Substratbindung des periplasmatischen Chaperons SurA aus <i>Escherichia coli</i>
(2006-05-16)The Escherichia coli protein SurA which has been characterized as a periplasmic peptidyl-prolyl-isomerase (PPIase) and chaperon is involved in the maturation of trimeric outer ... -
Directed evolution of novel properties starting from HisF of <i>Thermotoga maritima</i> as a structural scaffold
(2006-01-24)tHisF, imidazole glycerol phosphate synthase from hyperthermophilic organism T. maritima, with a (ba)8-barrel structure was used as scaffold for directed evolution of enzymes. The ... -
Crystal structure of a human U5 snRNP specific binary complex and crystal structure of a histone deacetylase-like bacterial amidohydrolase
(2005-12-09)The crystal structure of the complex comprising the GYF-domain of U5-52K and the U5-15K protein has been determined at 2.35 Å resolution. The protein U5-52K (Lin1p) is a component of yeast ... -
Entwicklung von Substraten und Inhibitoren pharmakologisch relevanter Proteintargets
(2005-11-14)Thrombin: A series of thrombin inhibitors were generated by using powerful computer-assisted multiparameter optimization process. The process was organized in design cycles, ... -
Neue Enzyminhibitoren und Rezeptoragonisten durch Variation funktionaler Schleifen von Mikroproteinen
(2005-10-25)Cystine knot microproteins are peptidic biomolecules with approximately 28-40 amino acids in length. They are able to fold into extremely stable threedimensional structures characterized ... -
Entwicklung eines HTS-geeigneten Enzymtests für Histondeacetylasen zur Entwicklung von HDAC-Inhibitoren
(2004-09-27)During the past years the pivotal role of histone deacetylases (HDACs) in tumourgenesis was discovered. These enzymes then were quickly ranked as molecular targets by the pharmaceutical ... -
Kombinatorische Synthese einer Genbibliothek und Analyse ihrer statistischen Struktur
(2004-05-14)Considering calculated parameters and using appropriate mixing ratios of codons during the DNA synthesis a gene library with determined population structure was generated. The partial ...