Within this thesis, two fragments of the natural product Parnafungin C, a highly functionalized chiral chromane with the correct absolute and relative configuration of all stereogenic centers as well as a biaryl system ...

The general objective of this thesis is to demonstrate the synthetic utility of the domino concept in the complex setting of natural product synthesis. Key step is a palladium-catalyzed domino Wacker/carbonylation/methoxylation ...

To date most anticancer agents interact with the cell cycle and therefore traditionally damage only cells with high proliferation rates. The usually insufficient differentiation between normal and malignant cells results ...

The chemotherapy of malign tumours is severely restricted due to severe side effects of the available anticancer agents. A novel approach to overcome these limitations is the Antibody ...

Despite considerable efforts towards the development of efficient cancer therapies, most anti-cancer agents applied so far in the clinic cause severe side effects because their cytotoxic ...

In this context, the domino reactions proved to be an excellent tool to access complex molecules from simple substrates in environmentally and economically sustainable way. This ...

The work in this thesis has been concerned with attempts to develop concise synthetic routes to the natural product mensacarcin, which is a novel polyfunctionalised hexahydroanthracene ...