Browsing Naturwissenschaften, Mathematik und Informatik by Referee "Janshoff, Andreas Prof. Dr."
Now showing items 1-20 of 28
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Development of Bone Adhesive Materials based on Collagen-mimetic Peptides and Carbene-mediated Diazirine Crosslinkers
(2024-08-22)Traditional mechanical fixation methods such as screws, support plates, staples, and sutures remain predominant in treating bone trauma. However, these methods can cause localized tissue damage, leading to infection and ... -
Investigation of active mechanical properties in the cytoplasm of living cells
(2024-07-09)Over the past decades, the study of intracellular active mechanical properties has experienced a growth in interest. This is mainly caused by recognizing that vital cellular functions rely on the intricate interplay ... -
Testing tube model predictions on semi-flexible polymer networks
(2023-11-13)The mechanical properties of simple entangled actin filament networks in eukaryotes are well understood as they are predictable with model systems. The high complexity of cellular actin structures like the cell cortex for ... -
Epithelial Cells under Mechanical Strain: an Investigation
(2022-06-29)Cells are the minimal living unit of the body. Each cell plays a vital role that must withstand various stresses, from chemical environments to mechanical strain and temperature variations. One of these vital cell types ... -
Detecting the Undetectable: Functional Protein Motions in the Hidden Timescale Window Revealed by NMR Relaxation Measurements
(2022-05-19)About 50 years ago, even before NMR was ready to determine structure of proteins, it could unveil a surprising motion in aromatic side-chain (Wuthrich & Wagner, 1975) from 1D 1H spectra. With decades of development, NMR ... -
Precise Nanoengineering of Polymer Functionalized Nanomaterials with Silica as Coating and Templating Tools
(2022-05-10)The construction of a well-defined hybrid nanostructure becomes possible if functional polymer meets inorganic nanomaterials in a well-designed way. To fully control the structure of the nanohybrid and create the synergy ... -
Herstellung und Charakterisierung von Polymernetzwerken im Kontext der präparativen Membranchromatographie
(2022-03-04)Preparative chromatography is an essential part in the industrial purification of biopharmaceuticals and thus allows the targeted therapy of severe diseases like cancer, multiple sclerosis or rheumatism. It enables the ... -
In and through the membrane by solid-state NMR: investigations of the human voltage-dependent anion channel 1 and Nup98-derived FG-domains
(2022-02-22)Magic-angle-spinning NMR spectroscopy is a powerful tool for the investigation of protein structure, dynamics and interactions at atomic resolution. We have applied this technique to investigate two widely different systems: ... -
Fast, Three-Dimensional Fluorescence Imaging of Living Cells
(2022-01-21)This thesis focuses on multi-plane fluorescence microscopy for fast live-cell imaging. To improve the performance of multi-plane microscopy, I developed new image analysis methods. I used these methods to measure and analyze ... -
Fluoreszente Sonden mit gesteigerter Signalintensität für die Lebendzell-Mikroskopie
(2021-09-02)In the past decades key findings in light microscopy has extended the possibilities of optical imaging methods. Imaging of living cells with a detailed visualization of proteins, structures and organelles has become one ... -
Active Matter in Confined Geometries - Biophysics of Artificial Minimal Cortices
(2020-12-18)Essential physiological processes, such as cell motility, adhesion, growth and differentiation are determined by the ability of cells to modify their mechanical properties. Consequently, both the vitality as well as ... -
Binary Planet–Satellite Nanostructure Using RAFT Polymer
(2020-08-06)This thesis provides a series of strategies to fabricate hierarchically arranged nanohybrids from distinct nanoparticles using polymer linkers. Benefit from the controlled reversible-deactivation radical polymerization ... -
Modeling electrodynamics in the vicinity of metal nanostructures
(2019-03-08)In this work, we show how a profound theoretical understanding of a seemingly exotic phenomenon, namely the influence of metal structures on fluorescence lifetimes, has lead to the development of a microscopy technique ... -
Low-Voltage Electrowetting on Dielectrics Integrated and Investigated with Electrical Impedance Spectroscopy (LV-EWOD-EIS)
(2018-10-18)Electrowetting on dielectrics (EWOD) is an electrically controllable wetting effect, that has been applied in diverse fields including optics, displays and lab on a chip systems. However, the further development of EWOD ... -
Mechanosensing and Symmetry of Potassium Channels Studied by Molecular Dynamics Simulations
(2018-10-02)Potassium channels are relevant in a variety of physiological processes in all three kingdoms of life. In mammals these processes including nerve signaling, heartbeat regulation, and osmotic regulation of cells. Thus a ... -
Mechanical and biochemical stimulation of suspended cells in a microfluidic device probed with dual optical tweezers
(2018-01-30)Cells communicate with their environment through biochemical and mechanical interactions. They can respond to stimuli by undergoing shape- and, in some situations, volume changes. Key determinants of the mechanical response ... -
Anwendungsbezogene Weiterentwicklung der abbildenden Ellipsometrie
(2017-10-10)Since the work of Geim of graphene as the first 2D material, application and rese- arch of 2D materials is the main booming branch this decade. Overall the imaging techniques like RAMAN Imaging, AFM and optical microscopy ... -
X-Ray Micro- and Nano-Diffraction Imaging on Human Mesenchymal Stem Cells and Differentiated Cells
(2017-06-13)Recent advances in hard x-ray optics, instrumentation and detection have made it possible to probe biological samples by combining diffraction with raster scanning, using step sizes on the order of cellular organelle ... -
Single-Molecule Metal-Induced Energy Transfer: From Basics to Applications
(2016-12-16)Single-molecule detection and spectroscopy have revolutionized the field of fluorescence microscopy. Due to their enormous potential in studying physics, chemistry and biology at molecular level, the number of single-molecule ... -
Synthesis of fluorescent toxin and nucleotide derivatives to specifically address membrane proteins
(2015-07-15)Within this project, new tools for in vivo/in vitro labelling were developed and investigated, which may be utilized in the future to elucidate structures, localisation and distinct processes of biomolecules in their native ...