Browsing Naturwissenschaften, Mathematik und Informatik by Referee "Neher, Erwin Prof. Dr."
Now showing items 1-20 of 39
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The presynaptic protein Mover buffers synaptic plasticity at the hippocampal mossy fiber synapse
(2018-03-12)The increase in the complexity of brains in evolution is accompanied by a surprisingly small number of new synaptic proteins, in particular when considering the remarkably wider range of behavioral responses a primate shows ... -
Cytoskeletal reorganization in human blood platelets during spreading
(2017-06-21)Anucleate, human blood platelets play an important role in haemostasis to prevent excessive blood loss from a vascular damage. Their actin and microtubule (MT) cytoskeleton is especially responsible for bringing about ... -
The role of the presynaptic scaffold protein Bassoon in synaptic transmission at the mouse endbulb of Held synapse
(2013-06-20)Endbulbs of Held are large calyceal presynaptic terminals of auditory nerve fibers driving bushy cells in the AVCN. These synapses transmit precisely timed auditory signals up to high frequencies that provide the basis for ... -
Stoichiometric Biology of the Synapse
(2013-05-07)Synaptic transmission at chemical synapses relies on the fusion of neurotransmitter-loaded vesicles with the plasma membrane of the pre-synaptic terminal (exocytosis). The synaptic vesicle material is then retrieved from ... -
Study of synaptic vesicle cycling during exo- and endocytosis using optical approaches
(2012-09-25)In the central nervous system, communication between nerve cells mainly occurs at synapses via chemical neurotransmitters. Upon stimulation the transmitters are released by Ca2+-triggered exocytosis of synaptic vesicles ... -
Functional properties and Ca2+-dependent feedback modulation of voltage-gated Ca2+ channels in glutamatergic nerve terminals of the mammalian auditory brainstem
(2012-03-02)The functional properties of mammalian presynaptic nerve endings remain elusive since most terminals of the central nervous system are not accessible to direct electrophysiological recordings. ... -
Synaptic Targeting of Neurotransmitter Receptors is Regulated by Neurobeachin
(2011-11-14)In neuronal network, information is transferred mainly via chemical synapses. Typically, a neuron receives thousands of inputs, which are transmitted by the activation of a large number of ... -
Isolation and characterisation of synaptic vesicles from mouse brain
(2011-08-08)All eukaryotic cells exhibit a constant turnover of membrane components via trafficking of vesicles between subcellular compartments. A classical example of a dynamic membrane delimited ... -
Molecular Mechanisms of Serotonergic Signaling: Role in Neuronal Outgrowth and Receptor Oligomerization
(2010-12-21)Role of 5-HT7/G12 signaling in morpho- and synaptogenesis. The neurotransmitter serotonin (5-hydroxytryptamine or 5-HT) modulates different aspects of early neuronal differentiation, including ... -
Die Rolle der Synaptische Kurzzeitplastizität im neuronale Schaltkreise
(2010-12-03)Neuronal microcircuit is built by neurons connected with dynamic synapses. Short-term synaptic plasticity is one form of the synaptic dynamics, which plays various roles in the circuit ... -
SNAREs in evoked and spontaneous neurotransmission
(2010-02-04)The SNARE-complex consisting of synaptobrevin-2, SNAP-25, and syntaxin-1 is necessary for evoked synaptic transmission, but the involvement of the extended SNARE- bundle in different phases ... -
Epac-mediated modulation of neurotransmitter release from cultured hippocampal neurons
(2008-07-15)cAMP regulates secretory processes through both protein kinase A (PKA)-independent and PKA-dependent signaling pathways. However, their relative contributions to fast neurotransmission are ... -
Role of the microtubulin-associated molecule tau in inflammatory-mediated axonal damage
(2008-02-14)Intracellular aggregates of the microtubule associated protein tau in neurites are the major component of neurofibrillary tangles in Alzheimer's disease and other neurodegenerative tauopathies. The exact molecular mechanism of ... -
Maturation of GABAergic signaling during brainstem development
(2007-07-13)In the central nervous system, γ-aminobutyric acid (GABA) is known to act as an inhibitory neurotransmitter, via ligand-gated GABAA receptor channels and G protein-coupled GABAB receptors. ... -
Synaptic physiology of the developing <i>Drosophila</i> neuromuscular junction
(2007-04-25)There is a large increase in the number of synapses, and a constant structural and functional remodelling of already established synaptic sites, during the development of both the vertebrate ... -
Investigation of Protein - Protein Interactions in Clathrin-Mediated Membrane Transport
(2006-11-13)Ever since it was reported that synaptic vesicle (SV) retrieval follows two kinetic phases, the molecular mechanisms corresponding to these kinetic modes have been controversially discussed. ... -
The role of auditory sensory input during functional pre- and postsynaptic maturation of the calyx of Held synapse
(2006-10-23)We studied how afferent nerve activity affects the in-vivo maturation of a fast glutamatergic CNS synapse, the calyx of Held. To address this question we exploited the distinct ... -
Visualization of the Ca2+-dependent regulation of voltage-gated Ether-à-go-go channels by FRET microscopy
(2006-08-22)Several studies have suggested a role for EAG channels in the regulation of neuronal excitability, possibly by contributing to the maintenance of the resting membrane potential. EAG channels ... -
SNARE assembly and regulation on membranes
(2006-08-01)The fusion of synaptic vesicles with the pre-synaptic plasma membrane is mediated by SNARE proteins. This work provides key insights into the behaviour of synaptobrevin, the SNARE protein ... -
Mechanisms of posttetanic potentiation and its possible role in maturation of the calyx of Held synapse
(2006-05-12)In this work, a hitherto overlooked form of short-term plasticity was identified at the calyx of Held, a glutamatergic excitatory synapse in the auditory brainstem pathway.Brief trains ...